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Logistic and linear regression were used to assess the association between ILA and MTL; Cox proportional hazards models were used to assess the association between MTL and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all three cohorts, ILA were associated with decreased MTL. In the COPDGene and AGES-Reykjavik cohorts, after adjustment there was greater than twofold increase in the odds of ILA when comparing the shortest quartile of telomere length to the longest quartile (OR 2.2, 95% CI 1.5\u20133.4, p=0.0001, and OR 2.6, 95% CI 1.4\u20134.9, p=0.003, respectively). In the FHS, those with ILA had shorter telomeres than those without ILA (\u2212767\u2005bp, 95% CI 76\u20131584\u2005bp, p=0.03). Although decreased MTL was associated with chronic obstructive pulmonary disease (OR 1.3, 95% CI 1.1\u20131.6, p=0.01) in COPDGene, the effect estimate was less than that noted with ILA. There was no consistent association between MTL and risk of death when comparing the shortest quartile of telomere length in COPDGene and AGES-Reykjavik (HR 0.82, 95% CI 0.4\u20131.7, p=0.6, and HR 1.2, 95% CI 0.6\u20132.2, p=0.5, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ILA are associated with decreased MTL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.01814-2021","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T12:25:24Z","timestamp":1643891124000},"page":"2101814","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Interstitial lung abnormalities are associated with decreased mean telomere 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