{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:35:22Z","timestamp":1790523322226,"version":"4.1.0"},"reference-count":27,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,12,6]]},"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>We aimed to investigate sarcoidosis mortality in a large, population-based cohort, taking into account disease heterogeneity.<\/jats:p><jats:p>Individuals with incident sarcoidosis (n=8207) were identified from the Swedish National Patient Register using International Classification of Disease codes (2003\u20122013). In a subset, cases receiving treatment \u00b13\u2005months from diagnosis were identified from the Prescribed Drug Register. Nonsarcoidosis comparators from the general population were matched to cases 10:1 on birth year, sex and county. Individuals were followed for all-cause death in the Cause of Death Register. Adjusted mortality rates, rate differences and hazard ratios (HRs) were estimated, stratifying by age, sex and treatment status.<\/jats:p><jats:p>The mortality rate was 11.0 per 1000\u2005person-years in sarcoidosis<jats:italic>versus<\/jats:italic>6.7 in comparators (rate difference 2.7 per 1000\u2005person-years). The HR for death was 1.61 (95% CI 1.47\u20121.76), with no large variation by age or sex. For cases not receiving treatment within the first 3\u2005months, the HR was 1.13 (95% CI 0.94\u20121.35). The HR was 2.34 (95% CI 1.99\u20122.75) for those receiving treatment.<\/jats:p><jats:p>Individuals with sarcoidosis are at a higher risk of death compared to the general population. For the majority, the increased risk is small. However, patients whose disease leads to treatment around diagnosis have a two-fold increased risk of death. Future interventions should focus on this vulnerable group.<\/jats:p>","DOI":"10.1183\/13993003.01815-2017","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T01:55:21Z","timestamp":1519264521000},"page":"1701815","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":85,"title":["Sarcoidosis mortality in Sweden: a\u00a0population-based cohort study"],"prefix":"10.1183","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9769-324X","authenticated-orcid":false,"given":"Marios","family":"Rossides","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Kullberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Askling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Eklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Grunewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3677-9736","authenticated-orcid":false,"given":"Elizabeth V.","family":"Arkema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"2024101909301696000_51.2.1701815.1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.2.ats4-99"},{"key":"2024101909301696000_51.2.1701815.2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00477-2016"},{"key":"2024101909301696000_51.2.1701815.3","first-page":"50","article-title":"Pulmonary sarcoidosis in the Nordic countries 1950\u20131982. Epidemiology and clinical picture","volume":"7","author":"Milman","year":"1990","journal-title":"Sarcoidosis"},{"key":"2024101909301696000_51.2.1701815.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1679OC"},{"key":"2024101909301696000_51.2.1701815.5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.5588\/ijtld.11.0077","article-title":"Mortality trends for tuberculosis and sarcoidosis in English populations, 1979\u20132008","volume":"16","author":"Duncan","year":"2012","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024101909301696000_51.2.1701815.6","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00457-2016"},{"key":"2024101909301696000_51.2.1701815.7","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.062836"},{"key":"2024101909301696000_51.2.1701815.8","first-page":"128","article-title":"Mortality among African American women with sarcoidosis: data from the Black Women's Health Study","volume":"30","author":"Tukey","year":"2013","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2024101909301696000_51.2.1701815.9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1183\/09031936.93.06030349","article-title":"Vital prognosis in intrathoracic sarcoidosis with special reference to pulmonary function and radiological stage","volume":"6","author":"Viskum","year":"1993","journal-title":"Eur Respir J"},{"key":"2024101909301696000_51.2.1701815.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.10.024"},{"key":"2024101909301696000_51.2.1701815.11","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"2024101909301696000_51.2.1701815.12","unstructured":"Svensk Lungmedicinsk F\u00f6rening (Swedish Respiratory Society) . V\u00e5rdprogram f\u00f6r Sarkoidos. [Guidelines for Sarcoidosis.] G\u00f6teborg, Mediahuset, 2014."},{"key":"2024101909301696000_51.2.1701815.13","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283642a7a"},{"key":"2024101909301696000_51.2.1701815.14","doi-asserted-by":"publisher","DOI":"10.1186\/1742-5573-7-4"},{"key":"2024101909301696000_51.2.1701815.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2003.10.004"},{"key":"2024101909301696000_51.2.1701815.16","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/01.EDE.0000071419.41011.cf","article-title":"Semi-automated sensitivity analysis to assess systematic errors in observational data","volume":"14","author":"Lash","year":"2003","journal-title":"Epidemiology"},{"key":"2024101909301696000_51.2.1701815.17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1338OC"},{"key":"2024101909301696000_51.2.1701815.18","unstructured":"U.S. Department of Health & Human Services . The Health Consequences of Smoking \u2013 50 Years of Progress: A Report of the Surgeon General. Atlanta, GA, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014."},{"key":"2024101909301696000_51.2.1701815.19","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-249OC"},{"key":"2024101909301696000_51.2.1701815.20","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009096"},{"key":"2024101909301696000_51.2.1701815.21","first-page":"204","article-title":"Two year prognosis of sarcoidosis: the ACCESS experience","volume":"20","author":"Judson","year":"2003","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2024101909301696000_51.2.1701815.22","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1378\/chest.14-1120","article-title":"Racial difference in sarcoidosis mortality in the United States","volume":"147","author":"Mirsaeidi","year":"2015","journal-title":"Chest"},{"key":"2024101909301696000_51.2.1701815.23","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-209058"},{"key":"2024101909301696000_51.2.1701815.24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1415"},{"key":"2024101909301696000_51.2.1701815.25","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1082OC"},{"key":"2024101909301696000_51.2.1701815.26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.5.9904045"},{"key":"2024101909301696000_51.2.1701815.27","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01290-2016"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01815-2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:51:36Z","timestamp":1740379896000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01815-2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,21]]},"published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1183\/13993003.01815-2017"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01815-2017","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}