{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:45:32Z","timestamp":1789343132732,"version":"build-2803163510"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CIDRI Clinical Fellowship and Wellcome Trust","award":["204755\/2\/16\/z"],"award-info":[{"award-number":["204755\/2\/16\/z"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HU 2731\/1-1"],"award-info":[{"award-number":["HU 2731\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation South Africa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002806","name":"Discovery Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002806","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2019,12,21]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Indoor air pollution and maternal smoking during pregnancy are associated with respiratory symptoms in infants, but little is known about the direct association with lung function or interactions with genetic risk factors. We examined associations of exposure to indoor particulate matter with a 50% cut-off aerodynamic diameter of 10\u2005\u00b5m (PM<jats:sub>10<\/jats:sub>) and maternal smoking with infant lung function and the role of gene\u2013environment interactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Drakenstein Child Health Study, a South African birth cohort, were analysed (n=270). Lung function was measured at 6\u2005weeks and 1\u2005year of age, and lower respiratory tract infection episodes were documented. We measured pre- and postnatal PM<jats:sub>10<\/jats:sub>exposures using devices placed in homes, and prenatal tobacco smoke exposure using maternal urine cotinine levels. Genetic risk scores determined from associations with childhood-onset asthma in the UK Biobank were used to investigate effect modifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pre- and postnatal exposure to PM<jats:sub>10<\/jats:sub>as well as maternal smoking during pregnancy were associated with reduced lung function at 6\u2005weeks and 1\u2005year as well as with lower respiratory tract infection in the first year. Due to a significant interaction between the genetic risk score and prenatal exposure to PM<jats:sub>10<\/jats:sub>, infants carrying more asthma-related risk alleles were more susceptible to PM<jats:sub>10<\/jats:sub>-associated reduced lung function (p<jats:sub>interaction<\/jats:sub>=0.007). This interaction was stronger in infants with Black African ancestry (p<jats:sub>interaction<\/jats:sub>=0.001) and nonexistent in children with mixed ancestry (p<jats:sub>interaction<\/jats:sub>=0.876).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PM<jats:sub>10<\/jats:sub>and maternal smoking exposures were associated with reduced lung function, with a higher susceptibility for infants with an adverse genetic predisposition for asthma that also depended on the infant's ancestry.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.01831-2019","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T20:29:20Z","timestamp":1579206560000},"page":"1901831","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":44,"title":["Genetic susceptibility to asthma increases the vulnerability to indoor air pollution"],"prefix":"10.1183","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6005-417X","authenticated-orcid":false,"given":"Anke","family":"H\u00fcls","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneesa","family":"Vanker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastassja","family":"Koen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia L.","family":"MacIsaac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.S.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia E.","family":"Ramadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Sly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7218-7810","authenticated-orcid":false,"given":"Dan J.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Kobor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Zar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"2024102101202185000_55.3.1901831.1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S2213-2600(14)70168-7","article-title":"Respiratory risks from household air pollution in low and middle income countries","volume":"2","author":"Gordon","year":"2014","journal-title":"Lancet Respir Med"},{"key":"2024102101202185000_55.3.1901831.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31679-8"},{"key":"2024102101202185000_55.3.1901831.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61388-8"},{"key":"2024102101202185000_55.3.1901831.4","unstructured":"World Health Organization. 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