{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:03:14Z","timestamp":1791421394498,"version":"4.3.3"},"reference-count":32,"publisher":"European Respiratory Society (ERS)","issue":"6","funder":[{"name":"National Science Foundation of China","award":["81370109"],"award-info":[{"award-number":["81370109"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["134119a6400, 12JC1402300"],"award-info":[{"award-number":["134119a6400, 12JC1402300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["Innovation Program: 13SG21"],"award-info":[{"award-number":["Innovation Program: 13SG21"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,1,26]]},"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Bronchiectasis and asthma are common respiratory diseases worldwide. However, the influence of asthma on bronchiectasis remains unclear. The objective of this study is to analyse the effects of asthma on bronchiectasis exacerbation.<\/jats:p><jats:p>Data from inpatients diagnosed with bronchiectasis with or without asthma at Shanghai Pulmonary Hospital (Shanghai, China) between January 2013 and December 2014 were retrospectively collected and analysed. 249 patients with only bronchiectasis and 214 patients with both bronchiectasis and asthma were included in the study. Follow-up records were used to evaluate the effect of asthma on bronchiectasis exacerbation.<\/jats:p><jats:p>The variables found to be independently associated with bronchiectasis exacerbations were age (OR 1.07, 95% CI 1.03\u20131.11; p&lt;0.001), duration of symptoms (OR 1.06, 95% CI 1.03\u20131.09; p&lt;0.001), the presence of asthma (OR 2.6, 95% CI 1.15\u20135.88; p=0.021), forced expiratory volume in 1\u2005s &lt;50% predicted (OR 4.03, 95% CI 1.75\u20139.26; p=0.001), isolation of<jats:italic>Pseudomonas aeruginosa<\/jats:italic>in sputum (OR 2.41, 95% CI 1.00\u20135.79; p=0.05) and lung lesion extension to more than two lobes (OR 2.73, 95% CI 1.16\u20136.45; p=0.022).<\/jats:p><jats:p>The existence of asthma was associated with an independent increase in risk of bronchiectasis exacerbation.<\/jats:p>","DOI":"10.1183\/13993003.01862-2015","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T05:49:45Z","timestamp":1460612985000},"page":"1680-1686","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":95,"title":["Asthma and bronchiectasis exacerbation"],"prefix":"10.1183","volume":"47","author":[{"given":"Bei","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Wen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Fu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"key":"2024102023594780000_47.6.1680.1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200206"},{"key":"2024102023594780000_47.6.1680.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2010.01871.x"},{"key":"2024102023594780000_47.6.1680.3","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.142778"},{"key":"2024102023594780000_47.6.1680.4","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2014.77.5.209"},{"key":"2024102023594780000_47.6.1680.5","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00853-2015"},{"key":"2024102023594780000_47.6.1680.6","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198206000-00001"},{"key":"2024102023594780000_47.6.1680.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201208-1518OC"},{"key":"2024102023594780000_47.6.1680.8","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.188.3.8351357"},{"key":"2024102023594780000_47.6.1680.9","doi-asserted-by":"crossref","unstructured":"Borak J , Lefkowitz RY . Bronchial hyperresponsiveness. Occup Med 2015 [In press DOI: 10.1093\/occmed\/kqv158].","DOI":"10.1093\/occmed\/kqv158"},{"key":"2024102023594780000_47.6.1680.10","unstructured":"Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. www.ginasthma.org\/documents\/4 Date last accessed: April 2015. Date last updated: 2015."},{"key":"2024102023594780000_47.6.1680.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.02.002"},{"key":"2024102023594780000_47.6.1680.12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00003709"},{"key":"2024102023594780000_47.6.1680.13","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.3.198"},{"key":"2024102023594780000_47.6.1680.14","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1183\/09031936.00026313","article-title":"Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score","volume":"43","author":"Mart\u00ednez-Garc\u00eda","year":"2014","journal-title":"EurRespir J"},{"key":"2024102023594780000_47.6.1680.15","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00284602"},{"key":"2024102023594780000_47.6.1680.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.06.028"},{"key":"2024102023594780000_47.6.1680.17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09081601"},{"key":"2024102023594780000_47.6.1680.18","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00074605"},{"key":"2024102023594780000_47.6.1680.19","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.150885"},{"key":"2024102023594780000_47.6.1680.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-8707(39)90151-6"},{"key":"2024102023594780000_47.6.1680.21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1978.tb03224.x"},{"key":"2024102023594780000_47.6.1680.22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb00186.x"},{"key":"2024102023594780000_47.6.1680.23","doi-asserted-by":"publisher","DOI":"10.1136\/thx.44.11.948"},{"key":"2024102023594780000_47.6.1680.24","first-page":"375","article-title":"Pulmonary function tests and airway responsiveness to methacholine in chronic bronchiectasis of the adult","volume":"20","author":"Bahous","year":"1984","journal-title":"Bull Eur Physiopathol Respir"},{"key":"2024102023594780000_47.6.1680.25","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e31802fa16f"},{"key":"2024102023594780000_47.6.1680.26","doi-asserted-by":"crossref","first-page":"879783","DOI":"10.1155\/2015\/879783","article-title":"Cellular mechanisms underlying eosinophilic and neutrophilic airway inflammation in asthma","volume":"2015","author":"Pelaia","year":"2015","journal-title":"Mediators Inflamm"},{"key":"2024102023594780000_47.6.1680.27","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000124"},{"key":"2024102023594780000_47.6.1680.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.011"},{"key":"2024102023594780000_47.6.1680.29","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0202-z"},{"key":"2024102023594780000_47.6.1680.30","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu025"},{"key":"2024102023594780000_47.6.1680.31","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205918"},{"key":"2024102023594780000_47.6.1680.32","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-013-0560-0"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01862-2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:32:11Z","timestamp":1740378731000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01862-2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,13]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,5,31]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1183\/13993003.01862-2015"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01862-2015","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,13]]}}}