{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:52:36Z","timestamp":1791420756091,"version":"4.3.3"},"reference-count":45,"publisher":"European Respiratory Society (ERS)","issue":"3","funder":[{"name":"Sociedad Valenciana de Neumolog\u00eda"},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01772"],"award-info":[{"award-number":["PI16\/01772"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007509","name":"Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,1,29]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>The goal of this study was to assess the relationship between the severity of obstructive sleep apnoea (OSA) and the levels of carcinogenesis- and tumour growth-related biomarkers in patients with cutaneous melanoma.<\/jats:p><jats:p>This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea\u2013hypopnoea index (AHI) 0\u20135\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>), mild OSA (AHI 5\u201315\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>) and moderate\u2013severe OSA (AHI &gt;15\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>). ELISAs were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (vascular endothelial growth factor (VEGF), interleukin (IL)-8, intracellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM)-1) and markers of tumour aggressiveness (S100 calcium-binding protein B (S100B) and melanoma inhibitory activity (MIA)). A logistic model adjusted for age, sex and body mass index was fitted to each biomarker, and the AHI served as the dependent variable.<\/jats:p><jats:p>360 patients were included (52.2% male, median (interquartile range) age 55.5 (43.8\u201368.0) years and AHI 8.55 (2.8\u201319.5) events\u00b7h<jats:sup>\u22121<\/jats:sup>). The levels of VEGF, IL-8, ICAM-1, S100B and MIA were not related to the severity of OSA. The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate\u2013severe OSA: OR 2.35, p=0.013).<\/jats:p><jats:p>In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that could indicate the contribution of OSA in tumorigenesis<jats:italic>via<\/jats:italic>integrin-based adhesion.<\/jats:p>","DOI":"10.1183\/13993003.01885-2017","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T01:10:15Z","timestamp":1520557815000},"page":"1701885","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Biomarkers of carcinogenesis and tumour growth in patients with cutaneous melanoma and obstructive sleep apnoea"],"prefix":"10.1183","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-1255","authenticated-orcid":false,"given":"Fernando","family":"Santamaria-Martos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Ben\u00edtez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Gir\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Barb\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel-Angel","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep\u00a0M.","family":"Montserrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Nagore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Martorell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Campos-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Corral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1124-7108","authenticated-orcid":false,"given":"Valentin","family":"Cabriada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Abad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Mediano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Troncoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-7187","authenticated-orcid":false,"given":"Irene","family":"Cano-Pumarega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Fortuna Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinidad","family":"Diaz-Cambriles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Somoza-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Almendros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Farre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gozal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5695-348X","authenticated-orcid":false,"given":"Manuel","family":"S\u00e1nchez-de-la-Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"key":"2024102100241993000_51.3.1701885.1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.3.2005065"},{"key":"2024102100241993000_51.3.1701885.2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00043-0"},{"key":"2024102100241993000_51.3.1701885.3","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws342"},{"key":"2024102100241993000_51.3.1701885.4","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(12)70051-6"},{"key":"2024102100241993000_51.3.1701885.5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ejca.2016.05.005","article-title":"Diagnosis and treatment of melanoma. 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