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This definition is no longer arbitrary, but based on a scientific approach. However, this abnormal elevation of mPAP is not sufficient to define pulmonary vascular disease as it can be due to an increase in cardiac output or pulmonary arterial wedge pressure. Thus, this 6th WSPH Task Force proposes to include pulmonary vascular resistance \u22653\u2005Wood Units in the definition of all forms of pre-capillary PH associated with mPAP &gt;20\u2005mmHg. Prospective trials are required to determine whether this PH population might benefit from specific management.<\/jats:p>\n                  <jats:p>Regarding clinical classification, the main Task Force changes were the inclusion in group 1 of a subgroup \u201cpulmonary arterial hypertension (PAH) long-term responders to calcium channel blockers\u201d, due to the specific prognostic and management of these patients, and a subgroup \u201cPAH with overt features of venous\/capillaries (pulmonary veno-occlusive disease\/pulmonary capillary haemangiomatosis) involvement\u201d, due to evidence suggesting a continuum between arterial, capillary and vein involvement in PAH.<\/jats:p>","DOI":"10.1183\/13993003.01913-2018","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T18:55:12Z","timestamp":1544727312000},"page":"1801913","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":3398,"title":["Haemodynamic definitions and updated clinical classification of pulmonary hypertension"],"prefix":"10.1183","volume":"53","author":[{"given":"G\u00e9rald","family":"Simonneau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-6922","authenticated-orcid":false,"given":"David","family":"Montani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Celermajer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Denton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Gatzoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Krowka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-9143","authenticated-orcid":false,"given":"Rogerio","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"2019031507273954000_53.1.1801913.1","first-page":"35","article-title":"Chronic cor pulmonale. 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