{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:09:12Z","timestamp":1790460552496,"version":"4.1.0"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"6","funder":[{"name":"PHRC","award":["AOR 07076"],"award-info":[{"award-number":["AOR 07076"]}]},{"name":"Chancellerie des Universit\u00e9s de Paris, Fondation du Legs Poix","award":["637"],"award-info":[{"award-number":["637"]}]},{"name":"COMUE Sorbonne Paris Cit\u00e9","award":["FPI-SPC"],"award-info":[{"award-number":["FPI-SPC"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,2,28]]},"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>The objectives of this prospective study were: 1) to determine the prevalence and determinants of obstructive sleep apnoea (OSA) in patients with newly diagnosed idiopathic pulmonary fibrosis (IPF); 2) to determine whether OSA was associated with cardiovascular disease (CVD) as well as increased oxidative stress and levels of IPF biomarkers in the blood.<\/jats:p>\n                  <jats:p>\n                    A group of 45 patients with newly diagnosed IPF attended polysomnography. The prevalence of CVD and the severity of coronary artery calcification were investigated by high-resolution computed tomography. The levels of 8-hydroxydeoxyguanosine (8-OH-DG) and various IPF biomarkers in the blood were compared between patients with no or mild OSA (apnoea\u2013hypopnoea index (AHI) &lt;15 events\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), with moderate OSA (15 \u2264AHI &lt;30 events\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and with severe OSA (AHI \u226530 events\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ).\n                  <\/jats:p>\n                  <jats:p>\n                    The prevalence of moderate-to-severe OSA and severe OSA was 62% and 40%, respectively. AHI did not correlate with demographic or physiological data. All patients with severe OSA had a medical history of CVD,\n                    <jats:italic>versus<\/jats:italic>\n                    41.2% and 40% of those with no or mild OSA, or with moderate OSA, respectively (p&lt;0.0001). Ischaemic heart disease (IHD) and moderate-to-severe coronary artery calcifications were strongly associated with severe OSA. The 8-OH-DG and matrix metalloproteinase-7 serum levels were significantly increased in the severe OSA group.\n                  <\/jats:p>\n                  <jats:p>Moderate-to-severe OSA is highly prevalent in incident IPF and severe OSA is strongly associated with the presence of CVD, particularly IHD.<\/jats:p>","DOI":"10.1183\/13993003.01934-2016","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T20:10:19Z","timestamp":1496952619000},"page":"1601934","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":86,"title":["Obstructive sleep apnoea and related comorbidities in incident idiopathic pulmonary fibrosis"],"prefix":"10.1183","volume":"49","author":[{"given":"Thomas","family":"Gille","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Didier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marouane","family":"Boubaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loris","family":"Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohra","family":"Carton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Baran-Marszak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Sadoun-Danino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Isra\u00ebl-Biet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5591-0955","authenticated-orcid":false,"given":"Vincent","family":"Cottin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Gagnadoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Crestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pia","family":"d'Ortho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Brillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Valeyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilario","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Plan\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"2024101903563715000_49.6.1601934.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60052-4"},{"key":"2024101903563715000_49.6.1601934.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-007-9004-3"},{"key":"2024101903563715000_49.6.1601934.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2776"},{"key":"2024101903563715000_49.6.1601934.4","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-010-0336-5"},{"key":"2024101903563715000_49.6.1601934.5","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-014-1033-6"},{"key":"2024101903563715000_49.6.1601934.6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.smrv.2015.03.005","article-title":"Sleep and respiratory sleep disorders in idiopathic pulmonary fibrosis","volume":"26","author":"Milioli","year":"2016","journal-title":"Sleep Med Rev"},{"key":"2024101903563715000_49.6.1601934.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198611203152105"},{"key":"2024101903563715000_49.6.1601934.8","doi-asserted-by":"publisher","DOI":"10.1136\/thx.44.1.52"},{"key":"2024101903563715000_49.6.1601934.9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200404-552OC"},{"key":"2024101903563715000_49.6.1601934.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00195-5"},{"key":"2024101903563715000_49.6.1601934.11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0671OC"},{"key":"2024101903563715000_49.6.1601934.12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0894CI"},{"key":"2024101903563715000_49.6.1601934.13","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.5.551"},{"key":"2024101903563715000_49.6.1601934.14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200805-725OC"},{"key":"2024101903563715000_49.6.1601934.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.03.012"},{"key":"2024101903563715000_49.6.1601934.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.02.008"},{"key":"2024101903563715000_49.6.1601934.17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0041"},{"key":"2024101903563715000_49.6.1601934.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.01.008"},{"key":"2024101903563715000_49.6.1601934.19","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14a30.x"},{"key":"2024101903563715000_49.6.1601934.20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"2024101903563715000_49.6.1601934.21","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.1.2001008"},{"key":"2024101903563715000_49.6.1601934.22","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2101072"},{"key":"2024101903563715000_49.6.1601934.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"2024101903563715000_49.6.1601934.24","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.5.2103001"},{"key":"2024101903563715000_49.6.1601934.25","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2008"},{"key":"2024101903563715000_49.6.1601934.26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"2024101903563715000_49.6.1601934.27","unstructured":"Iber C , Ancoli-Israel S , Stuart Quan M . The American Academy of Sleep Medicine Manual for the Scoring of Sleep and Associated Events: Rules, Terminology, and Technical Specifications. 1st Edn. Westchester, American Academy of Sleep Medicine, 2007."},{"key":"2024101903563715000_49.6.1601934.28","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1696OC"},{"key":"2024101903563715000_49.6.1601934.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2010.01919.x"},{"key":"2024101903563715000_49.6.1601934.30","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.8.893"},{"key":"2024101903563715000_49.6.1601934.31","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s11325-014-1117-3","article-title":"Sleep-disordered breathing and idiopathic pulmonary fibrosis. Is there an association?","volume":"19","author":"Reid","year":"2015","journal-title":"Sleep Breath"},{"key":"2024101903563715000_49.6.1601934.32","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S2213-2600(16)30146-1","article-title":"Mild obstructive sleep apnoea: clinical relevance and approaches to management","volume":"4","author":"McNicholas","year":"2016","journal-title":"Lancet Respir Med"},{"key":"2024101903563715000_49.6.1601934.33","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201101-0058OC"},{"key":"2024101903563715000_49.6.1601934.34","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2735"},{"key":"2024101903563715000_49.6.1601934.35","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.5.1541"},{"key":"2024101903563715000_49.6.1601934.36","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.5664\/jcsm.3070","article-title":"Serum inflammatory markers in obstructive sleep apnea: a meta-analysis","volume":"9","author":"Nadeem","year":"2013","journal-title":"J Clin Sleep Med"},{"key":"2024101903563715000_49.6.1601934.37","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.067439"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.01934-2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:41:40Z","timestamp":1740361300000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.01934-2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,8]]},"published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1183\/13993003.01934-2016"],"URL":"https:\/\/doi.org\/10.1183\/13993003.01934-2016","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727697762.793539206","asserted-by":"object"}]},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}