{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:52:42Z","timestamp":1792205562423,"version":"4.4.0"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"name":"Research grant from Grifols"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,11,13]]},"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    is responsible for chronic infection in many bronchiectasis patients but it is not known whether it is associated with worse clinical outcomes independent of the underlying severity of disease.\n                  <\/jats:p>\n                  <jats:p>\n                    This study analysed data from 2596 bronchiectasis patients included from 10 different bronchiectasis clinical centres across Europe and Israel, with a 5-year follow-up period. Prevalence of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    chronic infection and its independent impact on exacerbations, hospitalisations, quality of life and mortality was assessed.\n                  <\/jats:p>\n                  <jats:p>\n                    The prevalence of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    chronic infection was 15.0% (n=389).\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    was associated with a higher mortality in a univariate analysis (hazard ratio (HR) 2.02; 95% (confidence interval) CI 1.53\u20132.66; p&lt;0.0001) but an independent impact on mortality was not found in a multivariate analysis (HR 0.98; 95% CI 0.70\u20131.36; p=0.89).\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    was independently associated with increased mortality only in patients with frequent exacerbations (two or more per year) (HR 2.03; 95% CI 1.36\u20133.03; p=0.001). An independent association with worse quality of life of 7.46 points (95% CI 2.93\u201312.00; p=0.001) was found in a multivariable linear regression.\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    was therefore found to be independently associated with exacerbation frequency, hospital admissions and worse quality of life. Mortality was increased in patients with\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    particularly in the presence of frequent exacerbations.\n                  <\/jats:p>","DOI":"10.1183\/13993003.01953-2017","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T20:50:22Z","timestamp":1517431822000},"page":"1701953","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":236,"title":["The independent contribution of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    infection to long-term clinical outcomes in bronchiectasis"],"prefix":"10.1183","volume":"51","author":[{"given":"David","family":"Ara\u00fajo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Shteinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0090-4531","authenticated-orcid":false,"given":"Stefano","family":"Aliberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter C.","family":"Goeminne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam T.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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