{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:47:37Z","timestamp":1793785657239,"version":"4.6.1"},"reference-count":41,"publisher":"European Respiratory Society (ERS)","issue":"5","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5P30CA01608"],"award-info":[{"award-number":["5P30CA01608"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL122711"],"award-info":[{"award-number":["R01HL122711"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,3,30]]},"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Differential gene expression in the airway epithelium of patients with asthma<jats:italic>versus<\/jats:italic>controls has been reported in several studies. However, there is no consensus on which genes are reproducibly affected in asthma. We sought to identify a consensus list of differentially expressed genes (DEGs) using a meta-analysis approach.<\/jats:p><jats:p>We identified eight studies with data that met defined inclusion criteria. These studies comprised 355 cases and 193 controls and involved sampling either bronchial or nasal epithelium. We conducted study-level analyses, followed by a meta-analysis. Likewise, we applied a meta-analysis framework to the results of study-level pathway enrichment.<\/jats:p><jats:p>We identified 1273 DEGs, 431 of which had not been identified in previous studies. 450 DEGs exhibited large effect sizes and were robust to study population differences in age, sex, race\/ethnicity, medication use, smoking status and exacerbations. The magnitude of differential expression of these 450 genes was highly similar in bronchial and nasal airway epithelia. Meta-analysis of pathway enrichment revealed a number of consistently dysregulated biological pathways, including putative transcriptional and post-transcriptional regulators.<\/jats:p><jats:p>In total, we identified a set of genes that is consistently dysregulated in asthma, that links to known and novel biological pathways, and that will inform asthma subtype identification.<\/jats:p>","DOI":"10.1183\/13993003.01962-2017","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T11:05:12Z","timestamp":1523531112000},"page":"1701962","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["Meta-analysis of airway epithelium gene expression in asthma"],"prefix":"10.1183","volume":"51","author":[{"given":"Yi-Hsuan","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana V.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2676-9232","authenticated-orcid":false,"given":"Samir N.P.","family":"Kelada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,4,12]]},"reference":[{"key":"2024102100262738000_51.5.1701962.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.007"},{"key":"2024102100262738000_51.5.1701962.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2014.09.014"},{"key":"2024102100262738000_51.5.1701962.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.049"},{"key":"2024102100262738000_51.5.1701962.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910061"},{"key":"2024102100262738000_51.5.1701962.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707413104"},{"key":"2024102100262738000_51.5.1701962.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200903-0392OC"},{"key":"2024102100262738000_51.5.1701962.7","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.jaci.2016.07.036","article-title":"The nasal methylome and childhood atopic asthma","volume":"139","author":"Yang","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2024102100262738000_51.5.1701962.8","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1164\/rccm.201608-1558LE","article-title":"The nasal methylome: a key to understanding allergic asthma","volume":"195","author":"Yang","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102100262738000_51.5.1701962.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.10.032"},{"key":"2024102100262738000_51.5.1701962.10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00070511"},{"key":"2024102100262738000_51.5.1701962.11","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/4.2.249"},{"key":"2024102100262738000_51.5.1701962.12","doi-asserted-by":"crossref","unstructured":"Bolstad BM , Collin F , Brettschneider J , et\u00a0al. 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