{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:21:11Z","timestamp":1790889671830,"version":"4.1.0"},"reference-count":38,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,2,22]]},"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso.<\/jats:p><jats:p>Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case\u2013control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter \u226410 and \u22642.5\u2005\u00b5m (PM<jats:sub>10<\/jats:sub>and PM<jats:sub>2.5<\/jats:sub>), road traffic, and ozone (O<jats:sub>3<\/jats:sub>) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French Institute for the Environment) assessments. Models took account of city and familial dependence.<\/jats:p><jats:p>The risk of current asthma increased with traffic intensity (adjusted (a)OR 1.09 (95% CI 1.00\u20131.18) per 5000 vehicles per day), with O<jats:sub>3<\/jats:sub>exposure (aOR 2.04 (95% CI 1.27\u20133.29) per 10\u2005\u00b5g\u00b7m<jats:sup>\u22123<\/jats:sup>) and with exhaled 8-iso concentration (aOR 1.50 (95% CI 1.06\u20132.12) per 1\u2005pg\u00b7mL<jats:sup>\u22121<\/jats:sup>). Among participants without asthma, exhaled 8-iso concentration increased with PM<jats:sub>2.5<\/jats:sub>exposure (adjusted (a)\u03b2 0.23 (95% CI 0.005\u20130.46) per 5\u2005\u00b5g\u00b7m<jats:sup>\u22123<\/jats:sup>), and decreased with O<jats:sub>3<\/jats:sub>and O<jats:sub>3-summer<\/jats:sub>exposures (a\u03b2 \u22120.20 (95% CI \u22120.39\u2013\u200a\u22120.01) and a\u03b2 \u22120.52 (95% CI \u22120.77\u2013\u200a\u22120.26) per 10\u2005\u00b5g\u00b7m<jats:sup>\u22123<\/jats:sup>, respectively).<\/jats:p><jats:p>Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and asthma in adults.<\/jats:p>","DOI":"10.1183\/13993003.02036-2017","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T13:47:09Z","timestamp":1523281629000},"page":"1702036","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Outdoor air 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