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Striated muscles other than the right ventricle are affected in PAH, such as the left ventricle, the diaphragm and peripheral skeletal muscles. Alterations in these striated muscles are associated with exercise intolerance and reduced quality of life. In this Back to Basics article on striated muscle function in PAH, we provide insight into the pathophysiological mechanisms causing muscle dysfunction in PAH and discuss potential new therapeutic strategies to restore muscle dysfunction.<\/jats:p>","DOI":"10.1183\/13993003.02052-2014","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T12:27:09Z","timestamp":1435926429000},"page":"832-842","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["The striated muscles in pulmonary arterial hypertension: adaptations beyond the right ventricle"],"prefix":"10.1183","volume":"46","author":[{"given":"Emmy","family":"Manders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Rain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm-Jan","family":"Bogaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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