{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:12:04Z","timestamp":1790075524353,"version":"4.0.1"},"reference-count":44,"publisher":"European Respiratory Society (ERS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Cluster of Excellence RESIST","award":["EXC 2155, DFG, German Research Foundation"],"award-info":[{"award-number":["EXC 2155, DFG, German Research Foundation"]}]},{"DOI":"10.13039\/501100010564","name":"German Center for Lung Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010564","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2022,3,25]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Comprehensive studies investigated the role of T-cells in asthma which led to personalised treatment options targeting severe eosinophilic asthma. However, little is known about the contribution of B-cells to this chronic inflammatory disease. In this study we investigated the contribution of various B-cell populations to specific clinical features in asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the All Age Asthma Cohort (ALLIANCE), a subgroup of 154 adult asthma patients and 28 healthy controls were included for B-cell characterisation by flow cytometry. Questionnaires, lung function measurements, blood differential counts and allergy testing of participants were analysed together with comprehensive data on B-cells using association studies and multivariate linear models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with severe asthma showed decreased immature B-cell populations while memory B-cells were significantly increased compared with both mild\u2013moderate asthma patients and healthy controls. Furthermore, increased frequencies of IgA<jats:sup>+<\/jats:sup>memory B-cells were associated with impaired lung function and specifically with parameters indicative for augmented resistance in the peripheral airways. Accordingly, asthma patients with small airway dysfunction (SAD) defined by impulse oscillometry showed increased frequencies of IgA<jats:sup>+<\/jats:sup>memory B-cells, particularly in patients with mild\u2013moderate asthma. Additionally, IgA<jats:sup>+<\/jats:sup>memory B-cells significantly correlated with clinical features of SAD such as exacerbations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With this study we demonstrate for the first time a significant association of increased IgA<jats:sup>+<\/jats:sup>memory B-cells with asthma and SAD, pointing towards future options for B-cell-directed strategies in preventing and treating asthma.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.02130-2021","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T16:25:48Z","timestamp":1653323148000},"page":"2102130","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["IgA<sup>+<\/sup>memory B-cells are significantly increased in patients with asthma and small airway dysfunction"],"prefix":"10.1183","volume":"60","author":[{"given":"Anika","family":"Habener","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-104X","authenticated-orcid":false,"given":"Ruth","family":"Grychtol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-7354","authenticated-orcid":false,"given":"Svenja","family":"Gaedcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"DeLuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Maria","family":"Dittrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Happle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Abdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Watz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-6465","authenticated-orcid":false,"given":"Inke Regina","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-0747","authenticated-orcid":false,"given":"Dominik","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias Volkmar","family":"Kopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-4515","authenticated-orcid":false,"given":"Erika","family":"von Mutius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bahmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Friedrich","family":"Rabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut","family":"Meyer-Bahlburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ALLIANCE Study Group as part of the German Center for Lung Research (DZL)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Roesler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Welchering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naschla","family":"Kohistani-Greif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Landgraf-Rauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Laubhahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Maison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Liebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Schaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Ege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Illi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Zeitlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Berbig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Marzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Schauberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Zissler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Schmidt-Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabell","family":"Ricklefs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesa","family":"Diekmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Liboschik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesche","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Sultansei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Weckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyde","family":"Nissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Kirsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Waschki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Herzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Biller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline I.","family":"Gaede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Bovermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Steinmetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berrit Liselotte","family":"Husstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Nitsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Veith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlen","family":"Szewczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folke","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aydin","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Schwerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dopfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adan Chari","family":"Jirmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mifflin-Rae","family":"Calveron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Foth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysanthi","family":"Skevaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Renz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Schildberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Rietschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"van Koningsbruggen-Rietschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Alcazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"2024102102575490000_60.5.2102130.1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S2213-2600(20)30105-3","article-title":"Prevalence and attributable health burden of chronic respiratory diseases, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"8","year":"2020","journal-title":"Lancet Respir Med"},{"key":"2024102102575490000_60.5.2102130.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30879-6"},{"key":"2024102102575490000_60.5.2102130.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201810-1944CI"},{"key":"2024102102575490000_60.5.2102130.4","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/all.14318","article-title":"Type 2 immunity in the skin and lungs","volume":"75","author":"Akdis","year":"2020","journal-title":"Allergy"},{"key":"2024102102575490000_60.5.2102130.5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jaci.2017.03.051","article-title":"B cells control maternofetal priming of allergy and tolerance in a murine model of allergic airway inflammation","volume":"141","author":"Happle","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"2024102102575490000_60.5.2102130.6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/imr.12937","article-title":"B regulatory cells in allergy","volume":"299","author":"Ma","year":"2021","journal-title":"Immunol Rev"},{"key":"2024102102575490000_60.5.2102130.7","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.jaci.2020.09.041","article-title":"Regulatory B cells control airway hyperreactivity and lung remodeling in a murine asthma model","volume":"147","author":"Habener","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"2024102102575490000_60.5.2102130.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04469.x"},{"key":"2024102102575490000_60.5.2102130.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.046"},{"key":"2024102102575490000_60.5.2102130.10","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402708"},{"key":"2024102102575490000_60.5.2102130.11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-041015-055531"},{"key":"2024102102575490000_60.5.2102130.12","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan8405"},{"key":"2024102102575490000_60.5.2102130.13","doi-asserted-by":"publisher","DOI":"10.1038\/nri3802"},{"key":"2024102102575490000_60.5.2102130.14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115369109"},{"key":"2024102102575490000_60.5.2102130.15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3389\/fimmu.2017.00275","article-title":"Monomeric immunoglobulin A from plasma inhibits human Th17 responses in vitro independent of FcalphaRI and DC-SIGN","volume":"8","author":"Saha","year":"2017","journal-title":"Front Immunol"},{"key":"2024102102575490000_60.5.2102130.16","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1164\/rccm.201802-0352OC","article-title":"Increased IgA expression in lung lymphoid follicles in severe chronic obstructive pulmonary disease","volume":"199","author":"Ladjemi","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102575490000_60.5.2102130.17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0759OC"},{"key":"2024102102575490000_60.5.2102130.18","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1164\/rccm.201812-2322OC","article-title":"Lung computational models and the role of the small airways in asthma","volume":"200","author":"Foy","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102575490000_60.5.2102130.19","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.jaci.2020.11.035","article-title":"Peripheral and proximal lung ventilation in asthma: short-term variation and response to bronchodilator inhalation","volume":"147","author":"Marshall","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"2024102102575490000_60.5.2102130.20","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1016\/j.jaip.2021.04.035","article-title":"Small airway dysfunction links asthma severity with physical activity and symptom control","volume":"9","author":"Abdo","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2024102102575490000_60.5.2102130.21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S2213-2600(19)30049-9","article-title":"Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study","volume":"7","author":"Postma","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2024102102575490000_60.5.2102130.22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12890-018-0705-6","article-title":"The All Age Asthma cohort (ALLIANCE) \u2013 from early beginnings to chronic disease: a longitudinal cohort study","volume":"18","author":"Fuchs","year":"2018","journal-title":"BMC Pulm Med"},{"key":"2024102102575490000_60.5.2102130.23","unstructured":"Global Initiative for Asthma (GINA) . Global Strategy for Asthma Management and Prevention. 2019. Available from: http:\/\/ginasthma.org\/"},{"key":"2024102102575490000_60.5.2102130.24","unstructured":"Bundes\u00e4rztekammer, Kassen\u00e4rztliche Bundesvereinigung, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften . Nationale VersorgungsLeitlinie Asthma Langfassung; 2009, 2. Auflage, Version 1.3. [National asthma health care guideline, long version; 2009, 2nd edition, version 1.3.] 2011. www.leitlinien.de\/themen\/asthma\/archiv\/pdf\/asthma-2-aufl-lang-1-3.pdf Date last accessed: 14 April 2022."},{"key":"2024102102575490000_60.5.2102130.25","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates","volume":"64","author":"Storey","year":"2002","journal-title":"J R Stat Soc Series B Stat Method"},{"key":"2024102102575490000_60.5.2102130.26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063366"},{"key":"2024102102575490000_60.5.2102130.27","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"2024102102575490000_60.5.2102130.28","doi-asserted-by":"publisher","DOI":"10.1111\/all.12510"},{"key":"2024102102575490000_60.5.2102130.29","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01827-2016"},{"key":"2024102102575490000_60.5.2102130.30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-305OC"},{"key":"2024102102575490000_60.5.2102130.31","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jaci.2019.10.037","article-title":"IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways","volume":"145","author":"Manson","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"2024102102575490000_60.5.2102130.32","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9804033"},{"key":"2024102102575490000_60.5.2102130.33","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s12931-020-01543-5","article-title":"Small airway dysfunction as predictor and marker for clinical response to biological therapy in severe eosinophilic asthma: a longitudinal observational study","volume":"21","author":"Abdo","year":"2020","journal-title":"Respir Res"},{"key":"2024102102575490000_60.5.2102130.34","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1629OC"},{"key":"2024102102575490000_60.5.2102130.35","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1164\/rccm.201703-0561OC","article-title":"Bronchial epithelial IgA secretion is impaired in asthma. Role of IL-4\/IL-13","volume":"197","author":"Ladjemi","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102575490000_60.5.2102130.36","doi-asserted-by":"publisher","DOI":"10.1159\/000092252"},{"key":"2024102102575490000_60.5.2102130.37","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0260-6"},{"key":"2024102102575490000_60.5.2102130.38","doi-asserted-by":"crossref","first-page":"109286","DOI":"10.1016\/j.celrep.2021.109286","article-title":"Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells","volume":"35","author":"Mathew","year":"2021","journal-title":"Cell Rep"},{"key":"2024102102575490000_60.5.2102130.39","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3942"},{"key":"2024102102575490000_60.5.2102130.40","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00011211"},{"key":"2024102102575490000_60.5.2102130.41","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/all.14010","article-title":"Associations of Th2, Th17, Treg cells, and IgA+ memory B cells with atopic disease in children: the Generation R Study","volume":"75","author":"Looman","year":"2020","journal-title":"Allergy"},{"key":"2024102102575490000_60.5.2102130.42","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1164\/rccm.201604-0866OC","article-title":"A severe asthma disease signature from gene expression profiling of peripheral blood from U-BIOPRED cohorts","volume":"195","author":"Bigler","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102575490000_60.5.2102130.43","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1111\/ajt.13932","article-title":"Biomarkers of tolerance in kidney transplantation: are we predicting tolerance or response to immunosuppressive treatment?","volume":"16","author":"Rebollo-Mesa","year":"2016","journal-title":"Am J Transplant"},{"key":"2024102102575490000_60.5.2102130.44","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1135-3"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.02130-2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:06:57Z","timestamp":1740380817000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.02130-2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,20]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,11,3]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1183\/13993003.02130-2021"],"URL":"https:\/\/doi.org\/10.1183\/13993003.02130-2021","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,20]]}}}