{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:14:59Z","timestamp":1791872099184,"version":"4.3.4"},"reference-count":38,"publisher":"European Respiratory Society (ERS)","issue":"6","funder":[{"DOI":"10.13039\/501100007602","name":"Programme Grants for Applied Research","doi-asserted-by":"publisher","award":["RP-PG-0109-10061"],"award-info":[{"award-number":["RP-PG-0109-10061"]}],"id":[{"id":"10.13039\/501100007602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000659","name":"Research Trainees Coordinating Centre","doi-asserted-by":"publisher","award":["DRF-2011-04-064"],"award-info":[{"award-number":["DRF-2011-04-064"]}],"id":[{"id":"10.13039\/501100000659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000659","name":"Research Trainees Coordinating Centre","doi-asserted-by":"publisher","award":["PDF-01-2008-023"],"award-info":[{"award-number":["PDF-01-2008-023"]}],"id":[{"id":"10.13039\/501100000659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,3,2]]},"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Chronic obstructive pulmonary disease (COPD) is greatly underdiagnosed worldwide and more efficient methods of case-finding are required. We developed and externally validated a risk score to identify undiagnosed COPD using primary care records.<\/jats:p><jats:p>We conducted a retrospective cohort analysis of a pragmatic cluster randomised controlled case-finding trial in the West Midlands, UK. Participants aged 40\u201379\u2005years with no prior diagnosis of COPD received a postal or opportunistic screening questionnaire. Those reporting chronic respiratory symptoms were assessed with spirometry. COPD was defined as presence of relevant symptoms with a post-bronchodilator forced expiratory volume in 1\u2005s\/forced vital capacity ratio below the lower limit of normal. A risk score was developed using logistic regression with variables available from electronic health records for 2398 participants who returned a postal questionnaire. This was externally validated among 1097 participants who returned an opportunistic questionnaire to derive the c-statistic, and the sensitivity and specificity of cut-points.<\/jats:p><jats:p>A risk score containing age, smoking status, dyspnoea, prescriptions of salbutamol and prescriptions of antibiotics discriminated between patients with and without undiagnosed COPD (c-statistic 0.74, 95% CI 0.68\u20130.80). A cut-point of \u22657.5% predicted risk had a sensitivity of 68.8% (95% CI 57.3\u201378.9%) and a specificity of 68.8% (95% CI 65.8.1\u201371.6%).<\/jats:p><jats:p>A novel risk score using routine data from primary care electronic health records can identify patients at high risk for undiagnosed symptomatic COPD. This score could be integrated with clinical information systems to help primary care clinicians target patients for case-finding.<\/jats:p>","DOI":"10.1183\/13993003.02191-2016","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:10:35Z","timestamp":1498176635000},"page":"1602191","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Predicting risk of undiagnosed COPD: development and validation of the TargetCOPD score"],"prefix":"10.1183","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0096-1413","authenticated-orcid":false,"given":"Shamil","family":"Haroon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9087-3945","authenticated-orcid":false,"given":"Peymane","family":"Adab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fitzmaurice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"2024101903570486000_49.6.1602191.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"2024101903570486000_49.6.1602191.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61290-3"},{"key":"2024101903570486000_49.6.1602191.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2535"},{"key":"2024101903570486000_49.6.1602191.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.2638"},{"key":"2024101903570486000_49.6.1602191.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00193809"},{"key":"2024101903570486000_49.6.1602191.6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/1471-2466-14-157","article-title":"TargetCOPD: a pragmatic randomised controlled trial of targeted case finding for COPD versus routine practice in primary care: protocol","volume":"14","author":"Jordan","year":"2014","journal-title":"BMC Pulm Med"},{"key":"2024101903570486000_49.6.1602191.7","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S2213-2600(16)30149-7","article-title":"Targeted case finding for chronic obstructive pulmonary disease versus routine practice in primary care (TargetCOPD): a cluster-randomised controlled trial","volume":"4","author":"Jordan","year":"2016","journal-title":"Lancet Respir Med"},{"key":"2024101903570486000_49.6.1602191.8","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.129395"},{"key":"2024101903570486000_49.6.1602191.9","doi-asserted-by":"crossref","first-page":"14011","DOI":"10.1038\/npjpcrm.2014.11","article-title":"Development and validation of a model to predict the 10-year risk of general practitioner-recorded COPD","volume":"24","author":"Kotz","year":"2014","journal-title":"NPJ Prim Care Respir Med"},{"key":"2024101903570486000_49.6.1602191.10","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2014-000060"},{"key":"2024101903570486000_49.6.1602191.11","first-page":"458","article-title":"An algorithm for the identification of undiagnosed COPD cases using administrative claims data","volume":"12","author":"Mapel","year":"2006","journal-title":"J Manag Care Pharm"},{"key":"2024101903570486000_49.6.1602191.12","unstructured":"NHS Digital. 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