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Its effect on airway function through 12\u2005months of age has not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether vitamin C supplementation to pregnant smokers is associated with a sustained increased airway function in their infants through 12\u2005months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a pre-specified secondary outcome of a randomised, double-blind, placebo-controlled trial that randomised 251 pregnant smokers between 13 and 23\u2005weeks of gestation: 125 to 500\u2005mg\u00b7day<jats:sup>\u22121<\/jats:sup>vitamin C and 126 to placebo. Smoking cessation counselling was provided. FEFs performed at 3 and 12\u2005months of age were analysed by repeated-measures analysis of covariance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FEFs were performed in 222 infants at 3\u2005months and 202 infants at 12\u2005months of age. The infants allocated to vitamin C had significantly increased FEFs over the first year of life compared to those allocated to placebo. The overall increased flows were 40.2\u2005mL\u00b7s<jats:sup>\u22121<\/jats:sup>for at FEF<jats:sub>75<\/jats:sub>(75% of forced vital capacity (FVC)) (adjusted 95% CI for difference 6.6\u201373.8; p=0.025); 58.3\u2005mL\u00b7s<jats:sup>\u22121<\/jats:sup>for FEF<jats:sub>50<\/jats:sub>(10.9\u2013105.8; p=0.0081); and 55.1\u2005mL\u00b7s<jats:sup>\u22121<\/jats:sup>for FEF<jats:sub>25\u201375<\/jats:sub>(9.7\u2013100.5; p=0.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In offspring of pregnant smokers randomised to vitamin C<jats:italic>versus<\/jats:italic>placebo, vitamin C during pregnancy was associated with a small but significantly increased airway function at 3 and 12\u2005months of age, suggesting a potential shift to a higher airway function trajectory curve. Continued follow-up is underway.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.02208-2019","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T21:15:48Z","timestamp":1593724548000},"page":"1902208","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Vitamin C to pregnant smokers persistently improves infant airway function to 12\u2005months of age: a randomised trial"],"prefix":"10.1183","volume":"56","author":[{"given":"Cindy T.","family":"McEvoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyndsey 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