{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:08:50Z","timestamp":1790802530479,"version":"4.1.0"},"reference-count":44,"publisher":"European Respiratory Society (ERS)","issue":"1","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["Poste d'accueil INSERM (C\u00f4me Bureau)"],"award-info":[{"award-number":["Poste d'accueil INSERM (C\u00f4me Bureau)"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012019","name":"Fondation du Souffle","doi-asserted-by":"publisher","award":["Pilot study grant"],"award-info":[{"award-number":["Pilot study grant"]}],"id":[{"id":"10.13039\/100012019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2023,8,17]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In critically ill patients receiving mechanical ventilation, dyspnoea is frequent, severe and associated with an increased risk of neuropsychological sequelae. We evaluated the efficacy of sensory interventions targeting the brain rather than the respiratory system to relieve dyspnoea in mechanically ventilated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients receiving mechanical ventilation for \u226548\u2005h and reporting dyspnoea (unidimensional dyspnoea visual analogue scale (Dyspnoea-VAS)) first underwent increased pressure support and then, in random order, auditory stimulation (relaxing music\n                      <jats:italic>versus<\/jats:italic>\n                      pink noise) and air flux stimulation (facial\n                      <jats:italic>versus<\/jats:italic>\n                      lower limb). Treatment responses were assessed using Dyspnoea-VAS, the Multidimensional Dyspnea Profile and measures of the neural drive to breathe (airway occlusion pressure (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>0.1<\/jats:sub>\n                      ) and electromyography of inspiratory muscles).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 46 patients (tracheotomy or intubation n=37; noninvasive ventilation n=9). Increasing pressure support decreased Dyspnoea-VAS by median 40\u2005mm (p&lt;0.001). Exposure to music decreased Dyspnoea-VAS compared with exposure to pink noise by median 40\u2005mm (p&lt;0.001). Exposure to facial air flux decreased Dyspnoea-VAS compared with limb air flux by median 30\u2005mm (p&lt;0.001). Increasing pressure support, but not music exposure and facial air flux, reduced\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>0.1<\/jats:sub>\n                      by median 3.3\u2005cmH\n                      <jats:sub>2<\/jats:sub>\n                      O (p&lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In mechanically ventilated patients, sensory interventions can modulate the processing of respiratory signals by the brain irrespective of the intensity of the neural drive to breathe. It should therefore be possible to alleviate dyspnoea without resorting to pharmacological interventions or having to infringe the constraints of mechanical ventilation lung protection strategies by increasing ventilatory support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.02215-2022","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T11:16:03Z","timestamp":1694085363000},"page":"2202215","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Sensory interventions to relieve dyspnoea in critically ill mechanically ventilated patients"],"prefix":"10.1183","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1597-8127","authenticated-orcid":false,"given":"C\u00f4me","family":"Bureau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9370-7301","authenticated-orcid":false,"given":"Marie-C\u00e9cile","family":"Ni\u00e9rat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxens","family":"Decav\u00e8le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Rivals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Dangers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Beurton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Virolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Deleris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Delemazure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2799-5418","authenticated-orcid":false,"given":"Julien","family":"Mayaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capucine","family":"Mor\u00e9lot-Panzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9191-6089","authenticated-orcid":false,"given":"Martin","family":"Dres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-7217","authenticated-orcid":false,"given":"Alexandre","family":"Demoule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"2026061109551398000_63.1.2202215.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-2042ST"},{"key":"2026061109551398000_63.1.2202215.2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31821e8779"},{"key":"2026061109551398000_63.1.2202215.3","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1164\/rccm.202108-1857OC","article-title":"Prevalence, intensity, and clinical impact of dyspnea in critically ill patients receiving invasive ventilation","volume":"205","author":"Demoule","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"2026061109551398000_63.1.2202215.4","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02637-2017"},{"key":"2026061109551398000_63.1.2202215.5","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200204000-00004"},{"key":"2026061109551398000_63.1.2202215.6","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1164\/rccm.201812-2248ED","article-title":"Respiratory suffering in the ICU: time for our next great cause","volume":"199","author":"Demoule","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2026061109551398000_63.1.2202215.7","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204701"},{"key":"2026061109551398000_63.1.2202215.8","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02099-2016"},{"key":"2026061109551398000_63.1.2202215.9","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(89)90017-0"},{"key":"2026061109551398000_63.1.2202215.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-2910-3"},{"key":"2026061109551398000_63.1.2202215.11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13613-021-00958-7","article-title":"Proportional assist ventilation relieves clinically significant dyspnea in critically ill ventilated patients","volume":"11","author":"Bureau","year":"2021","journal-title":"Ann Intensive Care"},{"key":"2026061109551398000_63.1.2202215.12","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001189"},{"key":"2026061109551398000_63.1.2202215.13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200612-1774OC"},{"key":"2026061109551398000_63.1.2202215.14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.523"},{"key":"2026061109551398000_63.1.2202215.15","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3153-z"},{"key":"2026061109551398000_63.1.2202215.16","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01159-2017"},{"key":"2026061109551398000_63.1.2202215.17","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.58"},{"key":"2026061109551398000_63.1.2202215.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.09.024"},{"key":"2026061109551398000_63.1.2202215.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2012.01480.x"},{"key":"2026061109551398000_63.1.2202215.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2006.00415.x"},{"key":"2026061109551398000_63.1.2202215.21","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01383-2017"},{"key":"2026061109551398000_63.1.2202215.22","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.3.948"},{"key":"2026061109551398000_63.1.2202215.23","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00316-2018"},{"key":"2026061109551398000_63.1.2202215.24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00038914"},{"key":"2026061109551398000_63.1.2202215.25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13613-020-00684-6","article-title":"Recruitment pattern of the diaphragm and extradiaphragmatic inspiratory muscles in response to different levels of pressure support","volume":"10","author":"Roesthuis","year":"2020","journal-title":"Ann Intensive Care"},{"key":"2026061109551398000_63.1.2202215.26","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(75)90059-6"},{"key":"2026061109551398000_63.1.2202215.27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00134-005-0012-6","article-title":"Acute effects of hyperoxemia on dyspnoea and respiratory variables during pressure support ventilation","volume":"32","author":"Volta","year":"2006","journal-title":"Intensive Care Med"},{"key":"2026061109551398000_63.1.2202215.28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1748-1716.1984.tb07482.x","article-title":"Breathing pattern and occlusion pressure during moderate and heavy exercise","volume":"122","author":"Lind","year":"1984","journal-title":"Acta Physiol Scand"},{"key":"2026061109551398000_63.1.2202215.29","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1097\/CCM.0b013e31828c2d7a","article-title":"Impact of ventilator adjustment and sedation\u2013analgesia practices on severe asynchrony in patients ventilated in assist-control mode","volume":"41","author":"Chanques","year":"2013","journal-title":"Crit Care Med"},{"key":"2026061109551398000_63.1.2202215.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.01.011"},{"key":"2026061109551398000_63.1.2202215.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.07.012"},{"key":"2026061109551398000_63.1.2202215.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.04.001"},{"key":"2026061109551398000_63.1.2202215.33","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1152\/jappl.1998.85.6.2169","article-title":"Nonchemical influence of inspiratory pressure support on inspiratory activity in humans","volume":"85","author":"Fauroux","year":"1998","journal-title":"J Appl Physiol"},{"key":"2026061109551398000_63.1.2202215.34","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00223314"},{"key":"2026061109551398000_63.1.2202215.35","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1097\/ALN.0000000000000805","article-title":"Diagnostic accuracy of respiratory distress observation scales as surrogates of dyspnea self-report in intensive care unit patients","volume":"123","author":"Persichini","year":"2015","journal-title":"Anesthesiology"},{"key":"2026061109551398000_63.1.2202215.36","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1245"},{"key":"2026061109551398000_63.1.2202215.37","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01873-2018"},{"key":"2026061109551398000_63.1.2202215.38","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02471-2018"},{"key":"2026061109551398000_63.1.2202215.39","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1081cp"},{"key":"2026061109551398000_63.1.2202215.40","first-page":"CD011008","article-title":"Opioids for the palliation of refractory breathlessness in adults with advanced disease and terminal illness","volume":"3","author":"Barnes","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2026061109551398000_63.1.2202215.41","doi-asserted-by":"crossref","first-page":"16572","DOI":"10.1038\/s41598-019-53152-y","article-title":"Adjusting ventilator settings to relieve dyspnoea modifies brain activity in critically ill patients: an electroencephalogram pilot study","volume":"9","author":"Raux","year":"2019","journal-title":"Sci Rep"},{"key":"2026061109551398000_63.1.2202215.42","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.4.826"},{"key":"2026061109551398000_63.1.2202215.43","doi-asserted-by":"publisher","DOI":"10.1191\/1479972306cd110ra"},{"key":"2026061109551398000_63.1.2202215.44","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0540-9"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.02215-2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:55:22Z","timestamp":1781196922000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.02215-2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,7]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,18]]},"published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1183\/13993003.02215-2022"],"URL":"https:\/\/doi.org\/10.1183\/13993003.02215-2022","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,7]]}}}