{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:37:56Z","timestamp":1787063876762,"version":"build-2736575974"},"reference-count":16,"publisher":"European Respiratory Society (ERS)","issue":"5","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2019,2,8]]},"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Current guidelines recommend invasive mediastinal staging in patients with centrally located radiographic stage T1N0M0 nonsmall cell lung cancer (NSCLC). The lack of a specific definition of a central tumour has resulted in discrepancies among guidelines and heterogeneity in practice patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our objective was to study specific definitions of tumour centrality and their association with occult nodal disease. Pre-operative chest computed tomography scans from patients with clinical (c) T1N0M0 NSCLC were processed with a dedicated software system that divides the lungs in thirds following vertical and concentric lines. This software accurately assigns tumours to a specific third based both on the location of the centre of the tumour and its most medial aspect, creating eight possible definitions of central tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>607 patients were included in our study. Surgery was performed for 596 tumours (98%). The overall pathological (p) N disease was: 504 (83%) N0, 56 (9%) N1, 47 (8%) N2 and no N3. The prevalence of N2 disease remained relatively low regardless of tumour location. Central tumours were associated with upstaging from cN0 to any N (pN1\/pN2). Two definitions were associated with upstaging to any N: concentric lines, inner one-third, centre of the tumour (OR 3.91, 95% CI 1.85\u20138.26; p&lt;0.001) and concentric lines, inner two-thirds, most medial aspect of the tumour (OR 1.91, 95% CI 1.23\u20132.97; p=0.004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We objectively identified two specific definitions of central tumours. While the rate of occult mediastinal disease was relatively low regardless of tumour location, central tumours were associated with upstaging from cN0 to any N.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.02220-2018","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T08:24:14Z","timestamp":1551342254000},"page":"1802220","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":59,"title":["Centrally located lung cancer and risk of\u00a0occult nodal disease: an objective evaluation of multiple definitions of tumour centrality with dedicated imaging software"],"prefix":"10.1183","volume":"53","author":[{"given":"Roberto F.","family":"Casal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Sepesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala-Eddin S.","family":"Sagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juerg","family":"Tschirren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Sunny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horiana B.","family":"Grosu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Eapen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Ost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"2024102100503398000_53.5.1802220.1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2355"},{"key":"2024102100503398000_53.5.1802220.2","first-page":"225","article-title":"Preoperative mediastinal lymph node staging for non-small cell lung cancer: 2014 update of the 2007 ESTS guidelines","volume":"3","author":"De Leyn","year":"2014","journal-title":"Transl Lung Cancer Res"},{"key":"2024102100503398000_53.5.1802220.3","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2013.0192"},{"key":"2024102100503398000_53.5.1802220.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.05.023"},{"key":"2024102100503398000_53.5.1802220.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.03.081"},{"key":"2024102100503398000_53.5.1802220.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.12.013"},{"key":"2024102100503398000_53.5.1802220.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.06.008"},{"key":"2024102100503398000_53.5.1802220.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.06.038"},{"key":"2024102100503398000_53.5.1802220.9","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.jtcvs.2012.06.050","article-title":"A prediction model for N2 disease in T1 non-small cell lung cancer","volume":"144","author":"Zhang","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024102100503398000_53.5.1802220.10","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182992421"},{"key":"2024102100503398000_53.5.1802220.11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1513\/AnnalsATS.201607-568BC","article-title":"What exactly is a centrally located lung tumor? 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