{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:30:01Z","timestamp":1791221401449,"version":"4.1.0"},"reference-count":105,"publisher":"European Respiratory Society (ERS)","issue":"1","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2020,7,24]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Sleep-related breathing disorders (SBDs) include obstructive apnoea, central apnoea and sleep-related hypoventilation. These nocturnal events have the potential to increase pulmonary arterial pressure (PAP) during sleep but also in the waking state. \u201cPure\u201d obstructive sleep apnoea syndrome (OSAS) is responsible for a small increase in PAP whose clinical impact has not been demonstrated. By contrast, in obesity hypoventilation syndrome (OHS) or overlap syndrome (the association of chronic obstructive pulmonary disease (COPD) with obstructive sleep apnoea (OSA)), nocturnal respiratory events contribute to the development of pulmonary hypertension (PH), which is often severe. In the latter circumstances, treatment of SBDs is essential in order to improve pulmonary haemodynamics.<\/jats:p><jats:p>Patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) are at risk of developing SBDs. Obstructive and central apnoea, as well as a worsening of ventilation\u2013perfusion mismatch, can be observed during sleep. There should be a strong suspicion of SBDs in such a patient population; however, the precise indications for sleep studies and the type of recording remain to be specified. The diagnosis of OSAS in patients with PAH or CTEPH should encourage treatment with continuous positive airway pressure (CPAP). The presence of isolated nocturnal hypoxaemia should also prompt the initiation of long-term oxygen therapy. These treatments are likely to avoid worsening of PH; however, it is prudent not to treat central apnoea and Cheyne\u2013Stokes respiration (CSR) with adaptive servo-ventilation in patients with chronic right-heart failure because of a potential risk of serious adverse effects from such treatment.<\/jats:p><jats:p>In this review we will consider the current knowledge of the consequences of SBDs on pulmonary haemodynamics in patients with and without chronic respiratory disease (group 3 of the clinical classification of PH) and the effect of treatments of respiratory events during sleep on PH. The prevalence and consequences of SBDs in PAH and CTEPH (groups 1 and 4 of the clinical classification of PH, respectively), as well as therapeutic options, will also be discussed.<\/jats:p>","DOI":"10.1183\/13993003.02258-2020","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T20:55:23Z","timestamp":1596488123000},"page":"2002258","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":136,"title":["Sleep-related breathing disorders and pulmonary hypertension"],"prefix":"10.1183","volume":"57","author":[{"given":"Yochai","family":"Adir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-2892","authenticated-orcid":false,"given":"Marc","family":"Humbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6056-202X","authenticated-orcid":false,"given":"Ari","family":"Chaouat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"2024102101552973000_57.1.2002258.1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"2024102101552973000_57.1.2002258.2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0970"},{"key":"2024102101552973000_57.1.2002258.3","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.2.150"},{"key":"2024102101552973000_57.1.2002258.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"2024102101552973000_57.1.2002258.5","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir Med"},{"key":"2024102101552973000_57.1.2002258.6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2334"},{"key":"2024102101552973000_57.1.2002258.7","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01914-2018"},{"key":"2024102101552973000_57.1.2002258.8","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00004513"},{"key":"2024102101552973000_57.1.2002258.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.069"},{"key":"2024102101552973000_57.1.2002258.10","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.12.1050"},{"key":"2024102101552973000_57.1.2002258.11","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2001.0185"},{"key":"2024102101552973000_57.1.2002258.12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.674028"},{"key":"2024102101552973000_57.1.2002258.13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.95.2.338"},{"key":"2024102101552973000_57.1.2002258.14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07122192"},{"key":"2024102101552973000_57.1.2002258.15","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12030679"},{"key":"2024102101552973000_57.1.2002258.16","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01887-2018"},{"key":"2024102101552973000_57.1.2002258.17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.4.1023"},{"key":"2024102101552973000_57.1.2002258.18","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/jappl.1992.72.2.583","article-title":"Cardiovascular changes associated with obstructive sleep apnea syndrome","volume":"72","author":"Stoohs","year":"1992","journal-title":"J Appl Physiol"},{"key":"2024102101552973000_57.1.2002258.19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1164\/ajrccm.149.1.8111575","article-title":"Time course of right ventricular stroke volume and output in obstructive sleep apneas","volume":"149","author":"Bonsignore","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102101552973000_57.1.2002258.20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.4.894"},{"key":"2024102101552973000_57.1.2002258.21","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1152\/jappl.1993.74.6.2969","article-title":"Neurocirculatory consequences of negative intrathoracic pressure vs. asphyxia during voluntary apnea","volume":"74","author":"Morgan","year":"1993","journal-title":"J Appl Physiol"},{"key":"2024102101552973000_57.1.2002258.22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/jappl.1995.79.2.581","article-title":"Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia","volume":"79","author":"Leuenberger","year":"1995","journal-title":"J Appl Physiol"},{"key":"2024102101552973000_57.1.2002258.23","first-page":"435","article-title":"Nocturnal hemodynamics in patients with sleep apnea","volume":"146","author":"Podszus","year":"1986","journal-title":"Eur J Respir Dis Suppl"},{"key":"2024102101552973000_57.1.2002258.24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1164\/ajrccm.150.1.8025778","article-title":"Cardiovascular effects of periodic obstructive and central apneas in dogs","volume":"150","author":"Tarasiuk","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102101552973000_57.1.2002258.25","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1152\/jappl.2001.90.6.2502","article-title":"Selected contribution: pulmonary hypertension in mice following intermittent hypoxia","volume":"90","author":"Fagan","year":"2001","journal-title":"J Appl Physiol"},{"key":"2024102101552973000_57.1.2002258.26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/sleep\/1.2.117","article-title":"Arterial blood gases and pulmonary and systemic arterial pressure during sleep in chronic obstructive pulmonary disease","volume":"1","author":"Coccagna","year":"1978","journal-title":"Sleep"},{"key":"2024102101552973000_57.1.2002258.27","first-page":"1119","article-title":"[Nocturnal changes in blood gases and pulmonary arterial pressure in chronic bronchitis patients with respiratory insufficiency (author's transl.)]","volume":"11","author":"Weitzenblum","year":"1982","journal-title":"Nouv Presse Med"},{"key":"2024102101552973000_57.1.2002258.28","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.1.6"},{"key":"2024102101552973000_57.1.2002258.29","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.6.482"},{"key":"2024102101552973000_57.1.2002258.30","first-page":"41","article-title":"Elevated nocturnal desaturation index predicts mortality in interstitial lung disease","volume":"29","author":"Corte","year":"2012","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2024102101552973000_57.1.2002258.31","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0097-2018"},{"key":"2024102101552973000_57.1.2002258.32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S2213-2600(16)00054-0","article-title":"Prevention and care of respiratory failure in obese patients","volume":"4","author":"P\u00e9pin","year":"2016","journal-title":"Lancet Respir Med"},{"key":"2024102101552973000_57.1.2002258.33","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0272-5231(21)00402-0","article-title":"Sleep in chronic obstructive lung disease","volume":"6","author":"Flenley","year":"1985","journal-title":"Clin Chest Med"},{"key":"2024102101552973000_57.1.2002258.34","doi-asserted-by":"crossref","first-page":"57545","DOI":"10.18632\/oncotarget.11296","article-title":"Chronic obstructive sleep apnea accelerates pulmonary remodeling via TGF-\u03b2\/miR-185\/CoLA1 signaling in a canine model","volume":"7","author":"Ding","year":"2016","journal-title":"Oncotarget"},{"key":"2024102101552973000_57.1.2002258.35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/bs.ctm.2018.09.002","article-title":"Endothelial extracellular vesicles in pulmonary function and disease","volume":"82","author":"Letsiou","year":"2018","journal-title":"Curr Top Membr"},{"key":"2024102101552973000_57.1.2002258.36","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.2.380"},{"key":"2024102101552973000_57.1.2002258.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.06.048"},{"key":"2024102101552973000_57.1.2002258.38","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01904-2018"},{"key":"2024102101552973000_57.1.2002258.39","first-page":"1159","article-title":"Continuous recording of the pulmonary and systemic arterial pressure during sleep in syndromes of hypersomnia with periodic breathing","volume":"8","author":"Coccagna","year":"1972","journal-title":"Bull Physiopathol Respir (Nancy)"},{"key":"2024102101552973000_57.1.2002258.40","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-6-714"},{"key":"2024102101552973000_57.1.2002258.41","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.2.8306039"},{"key":"2024102101552973000_57.1.2002258.42","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9805086"},{"key":"2024102101552973000_57.1.2002258.43","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1183\/09031936.95.08040537","article-title":"Pulmonary hypertension in obstructive sleep apnoea","volume":"8","author":"Laks","year":"1995","journal-title":"Eur Respir J"},{"key":"2024102101552973000_57.1.2002258.44","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440420115011"},{"key":"2024102101552973000_57.1.2002258.45","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.11.934"},{"key":"2024102101552973000_57.1.2002258.46","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01032-2015"},{"key":"2024102101552973000_57.1.2002258.47","first-page":"525","article-title":"Long-term cardiopulmonary sequelae in patients with sleep apnea and chronic lung disease","volume":"135","author":"Fletcher","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"2024102101552973000_57.1.2002258.48","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2776"},{"key":"2024102101552973000_57.1.2002258.49","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-010-0336-5"},{"key":"2024102101552973000_57.1.2002258.50","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-013-0834-3"},{"key":"2024102101552973000_57.1.2002258.51","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00009114"},{"key":"2024102101552973000_57.1.2002258.52","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.1.7812577"},{"key":"2024102101552973000_57.1.2002258.53","first-page":"e6","article-title":"Echocardiographic changes with positive airway pressure therapy in obesity hypoventilation syndrome: long-term Pickwick randomized controlled trial","volume":"200","author":"Masa","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102101552973000_57.1.2002258.54","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/cphy.c110057","article-title":"Central sleep apnea","volume":"3","author":"Javaheri","year":"2013","journal-title":"Compr Physiol"},{"key":"2024102101552973000_57.1.2002258.55","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0140-6736(78)90564-0","article-title":"Clinical hypoxia: causes, consequences, and correction","volume":"1","author":"Flenley","year":"1978","journal-title":"Lancet"},{"key":"2024102101552973000_57.1.2002258.56","doi-asserted-by":"publisher","DOI":"10.1378\/chest.75.2.109"},{"key":"2024102101552973000_57.1.2002258.57","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10081730"},{"key":"2024102101552973000_57.1.2002258.58","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2758"},{"key":"2024102101552973000_57.1.2002258.59","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00147712"},{"key":"2024102101552973000_57.1.2002258.60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02252.x"},{"key":"2024102101552973000_57.1.2002258.61","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1140"},{"key":"2024102101552973000_57.1.2002258.62","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"key":"2024102101552973000_57.1.2002258.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.10.026"},{"key":"2024102101552973000_57.1.2002258.64","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.3.894"},{"key":"2024102101552973000_57.1.2002258.65","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00225102"},{"key":"2024102101552973000_57.1.2002258.66","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1378"},{"key":"2024102101552973000_57.1.2002258.67","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-3035"},{"key":"2024102101552973000_57.1.2002258.68","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-010-0411-y"},{"key":"2024102101552973000_57.1.2002258.69","doi-asserted-by":"publisher","DOI":"10.1159\/000341182"},{"key":"2024102101552973000_57.1.2002258.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.11.013"},{"key":"2024102101552973000_57.1.2002258.71","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-3124"},{"key":"2024102101552973000_57.1.2002258.72","doi-asserted-by":"crossref","first-page":"277","DOI":"10.5664\/jcsm.3528","article-title":"Sleep disordered breathing in group 1 pulmonary arterial hypertension","volume":"10","author":"Minic","year":"2014","journal-title":"J Clin Sleep Med"},{"key":"2024102101552973000_57.1.2002258.73","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1253\/circj.CJ-18-0636","article-title":"Nocturnal hypoxemia, but not sleep apnea, is associated with a poor prognosis in patients with pulmonary arterial hypertension","volume":"82","author":"Nagaoka","year":"2018","journal-title":"Circ J"},{"key":"2024102101552973000_57.1.2002258.74","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"2024102101552973000_57.1.2002258.75","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200404-510OC"},{"key":"2024102101552973000_57.1.2002258.76","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/cphy.c110053","article-title":"Mechanical properties of the upper airway","volume":"2","author":"Strohl","year":"2012","journal-title":"Compr Physiol"},{"key":"2024102101552973000_57.1.2002258.77","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3390\/jcm9020410","article-title":"Skeletal and respiratory muscle dysfunctions in pulmonary arterial hypertension","volume":"9","author":"Riou","year":"2020","journal-title":"J Clin Med"},{"key":"2024102101552973000_57.1.2002258.78","doi-asserted-by":"crossref","first-page":"A47","DOI":"10.1016\/j.rmr.2016.10.100","article-title":"Hypertension art\u00e9rielle pulmonaire et troubles respiratoires du sommeil : une histoire de fluide?","volume":"34","author":"Jutant","year":"2017","journal-title":"Rev Mal Respir"},{"key":"2024102101552973000_57.1.2002258.79","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.arbres.2019.12.030","article-title":"Gas exchange and ventilatory efficiency during exercise in pulmonary vascular diseases","volume":"56","author":"Weatherald","year":"2020","journal-title":"Arch Bronconeumol"},{"key":"2024102101552973000_57.1.2002258.80","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02517-2017"},{"key":"2024102101552973000_57.1.2002258.81","first-page":"1217","article-title":"Tracheostomy in hypersomnia with periodic breathing","volume":"8","author":"Coccagna","year":"1972","journal-title":"Bull Physiopathol Respir (Nancy)"},{"key":"2024102101552973000_57.1.2002258.82","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.9.996"},{"key":"2024102101552973000_57.1.2002258.83","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.4_Pt_1.866"},{"key":"2024102101552973000_57.1.2002258.84","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10112578"},{"key":"2024102101552973000_57.1.2002258.85","doi-asserted-by":"publisher","DOI":"10.1159\/000050574"},{"key":"2024102101552973000_57.1.2002258.86","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.2010092"},{"key":"2024102101552973000_57.1.2002258.87","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi807"},{"key":"2024102101552973000_57.1.2002258.88","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/resp.12314","article-title":"Continuous positive airway pressure is associated with a decrease in pulmonary artery pressure in patients with obstructive sleep apnoea: a meta-analysis","volume":"19","author":"Sun","year":"2014","journal-title":"Respirology"},{"key":"2024102101552973000_57.1.2002258.89","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-016-9548-5"},{"key":"2024102101552973000_57.1.2002258.90","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cjca.2015.01.029","article-title":"Assessment of right ventricular function in obstructive sleep apnea syndrome and effects of continuous positive airway pressure therapy: a pilot study","volume":"31","author":"Vitarelli","year":"2015","journal-title":"Can J Cardiol"},{"key":"2024102101552973000_57.1.2002258.91","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.12.010"},{"key":"2024102101552973000_57.1.2002258.92","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0615"},{"key":"2024102101552973000_57.1.2002258.93","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01897-2018"},{"key":"2024102101552973000_57.1.2002258.94","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606599"},{"key":"2024102101552973000_57.1.2002258.95","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht540"},{"key":"2024102101552973000_57.1.2002258.96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0140-6736(79)90451-3","article-title":"Transient hypoxaemia during sleep in chronic bronchitis and emphysema","volume":"1","author":"Douglas","year":"1979","journal-title":"Lancet"},{"key":"2024102101552973000_57.1.2002258.97","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00015608"},{"key":"2024102101552973000_57.1.2002258.98","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-1-29"},{"key":"2024102101552973000_57.1.2002258.99","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.14510029"},{"key":"2024102101552973000_57.1.2002258.100","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1604344"},{"key":"2024102101552973000_57.1.2002258.101","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01889-2018"},{"key":"2024102101552973000_57.1.2002258.102","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.004"},{"key":"2024102101552973000_57.1.2002258.103","doi-asserted-by":"crossref","first-page":"335","DOI":"10.5664\/jcsm.7640","article-title":"Treatment of adult obstructive sleep apnea with positive airway pressure: an American Academy of Sleep Medicine clinical practice guideline","volume":"15","author":"Patil","year":"2019","journal-title":"J Clin Sleep Med"},{"key":"2024102101552973000_57.1.2002258.104","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506459"},{"key":"2024102101552973000_57.1.2002258.105","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01897-2015"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.02258-2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:36:12Z","timestamp":1740382572000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.02258-2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,3]]},"references-count":105,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,5]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1183\/13993003.02258-2020"],"URL":"https:\/\/doi.org\/10.1183\/13993003.02258-2020","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,3]]}}}