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We aimed to investigate the association between exposure to a mixture of phenols in pregnancy and infancy and children's respiratory health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Among 363 mother\u2013child pairs from the Suivi de l'Exposition \u00e0 la Pollution Atmosph\u00e9rique durant la Grossesse et Effets sur la Sant\u00e9 cohort, 12 phenols were measured in weekly-pooled urine samples collected twice during pregnancy (second and third trimesters) and in infancy (2\u2005months and 1\u2005year). Children's lung function was assessed through tidal breathing flow-volume loops and nitrogen multiple-breath washout at 2\u2005months, and standard and intra-breath oscillometry at 3\u2005years. Time-specific phenol exposure profiles were identified through cluster analysis and then studied in association with respiratory health using adjusted regression models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two exposure profiles were identified at each point in time, characterised by low <jats:italic>versus<\/jats:italic> high levels of several phenol compounds. Overall, high exposure profiles were associated with altered oscillometry parameters at 3\u2005years, particularly a high profile in the second trimester with higher frequency dependence of resistance and lower volume dependence of reactance, between a high profile at 2\u2005months and lower reactance at 7\u2005Hz, and between a high profile at 1\u2005year and higher area of the reactance curve, resistance at 7\u2005Hz and volume dependence of resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Using repeated and accurate assessments of phenol exposure, this study provides evidence of the deleterious effects of early-life exposure to a mixture of phenols on lung function in preschool children.<\/jats:p>\n               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