{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:06:17Z","timestamp":1790179577888,"version":"4.1.0"},"reference-count":43,"publisher":"European Respiratory Society (ERS)","issue":"1","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["820820"],"award-info":[{"award-number":["820820"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2025,4,18]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The <jats:italic>amount<\/jats:italic> of walking that people with COPD do is reduced. However, data on their <jats:italic>manner<\/jats:italic> of walking (<jats:italic>i.e.<\/jats:italic> gait) are still lacking. We characterised real-world gait in COPD by assessing levels and distributions of gait parameters, and comparing them across COPD severity and with healthy peers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>549 people with COPD from seven European sites and 19 healthy older adults wore single wearable devices (either Axivity AX6 or DynaPort MoveMonitor MM+) continuously for 1\u2005week, from which we identified walking bouts, calculated 15 digital mobility outcomes (DMOs) aggregated at the weekly level, and compared them across COPD severity levels and with healthy peers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the participants with COPD, 37% were female with a mean\u00b1<jats:sc>sd<\/jats:sc> age of 68\u00b18\u2005years and a post-bronchodilator forced expiratory volume in 1\u2005s of 54\u00b120% predicted. All gait DMOs were normally distributed and exhibited variability between participants (<jats:italic>e.g.<\/jats:italic> mean\u00b1<jats:sc>sd<\/jats:sc> walking speed of 0.83\u00b10.12\u2005m\u00b7s<jats:sup>\u22121<\/jats:sup>, ranging from 0.48 to 1.20\u2005m\u00b7s<jats:sup>\u22121<\/jats:sup>). Walking speed and cadence DMOs were lower with increasing disease severity (<jats:italic>e.g.<\/jats:italic> mean\u00b1<jats:sc>sd<\/jats:sc> walking speed of 0.88\u00b10.11, 0.85\u00b10.12, 0.80\u00b10.12 and 0.78\u00b10.14\u2005m\u00b7s<jats:sup>\u22121<\/jats:sup> across Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1 to 4, p&lt;0.001; mean\u00b1<jats:sc>sd<\/jats:sc> cadence of 93\u00b16, 91\u00b16 and 89\u00b17\u2005steps\u00b7min<jats:sup>\u22121<\/jats:sup> across GOLD A, B and E, p=0.013). Stride length and duration varied across COPD severity levels. Walking speed and cadence bout-to-bout variability only varied across dyspnoea severity levels. In a secondary analysis, we compared DMO data from people with COPD to a convenience sample of 19 healthy older adults (47% women, mean age 71\u00b16\u2005years) and found that walking speed and cadence varied between participants with COPD and healthy adults (<jats:italic>e.g.<\/jats:italic> mean\u00b1<jats:sc>sd<\/jats:sc> walking speed 0.83\u00b10.12 <jats:italic>versus<\/jats:italic> 0.90\u00b10.12\u2005m\u00b7s<jats:sup>\u22121<\/jats:sup>, p=0.041).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In people with COPD, gait DMOs are normally distributed and worsen as disease advances. Moreover, walking speed and cadence DMOs are significantly altered when compared to healthy peers. Further research should elucidate which DMOs can be improved with treatments to enhance mobility and reduce adverse events.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1183\/13993003.02303-2024","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T10:00:14Z","timestamp":1747908014000},"page":"2402303","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["How do people with COPD walk? 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