{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:24:55Z","timestamp":1793852695716,"version":"4.6.1"},"reference-count":139,"publisher":"European Respiratory Society (ERS)","issue":"6","license":[{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2021,10,18]]},"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Pulmonary arterial hypertension (PAH) is a rare dyspnoea-fatigue syndrome caused by a progressive increase in pulmonary vascular resistance and eventual right ventricular (RV) failure. In spite of extensive pulmonary vascular remodelling, lung function in PAH is generally well preserved, with hyperventilation and increased physiological dead space, but minimal changes in lung mechanics and only mild to moderate hypoxaemia and hypocapnia. Hypoxaemia is mainly caused by a low mixed venous oxygen tension from a decreased cardiac output. Hypocapnia is mainly caused by an increased chemosensitivity. Exercise limitation in PAH is cardiovascular rather than ventilatory or muscular. The extent of pulmonary vascular disease in PAH is defined by multipoint pulmonary vascular pressure\u2013flow relationships with a correction for haematocrit. Pulsatile pulmonary vascular pressure\u2013flow relationships in PAH allow for the assessment of RV hydraulic load. This analysis is possible either in the frequency domain or in the time domain. The RV in PAH adapts to increased afterload by an increased contractility to preserve its coupling to the pulmonary circulation. When this homeometric mechanism is exhausted, the RV dilates to preserve flow output by an additional heterometric mechanism. Right heart failure is then diagnosed by imaging of increased right heart dimensions and clinical systemic congestion signs and symptoms. The coupling of the RV to the pulmonary circulation is assessed by the ratio of end-systolic to arterial elastances, but these measurements are difficult. Simplified estimates of RV\u2013pulmonary artery coupling can be obtained by magnetic resonance or echocardiographic imaging of ejection fraction.<\/jats:p>","DOI":"10.1183\/13993003.02334-2021","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T13:00:15Z","timestamp":1636030815000},"page":"2102334","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":216,"title":["The physiological basis of pulmonary arterial hypertension"],"prefix":"10.1183","volume":"59","author":[{"given":"Robert","family":"Naeije","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel J.","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis J.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2021,11,4]]},"reference":[{"key":"2024102102434654000_59.6.2102334.1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"2024102102434654000_59.6.2102334.2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01889-2018"},{"key":"2024102102434654000_59.6.2102334.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.18.4.533"},{"key":"2024102102434654000_59.6.2102334.4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.42.6.1163"},{"key":"2024102102434654000_59.6.2102334.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.5.1207"},{"key":"2024102102434654000_59.6.2102334.6","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01900-2018"},{"key":"2024102102434654000_59.6.2102334.7","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1164\/rccm.201806-1160ST","article-title":"Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward. An Official American Thoracic Society Research Statement","volume":"198","author":"Lahm","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102434654000_59.6.2102334.8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"2024102102434654000_59.6.2102334.9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.898122"},{"key":"2024102102434654000_59.6.2102334.10","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.healun.2020.09.011","article-title":"Idiopathic pulmonary arterial hypertension phenotypes determined by cluster analysis from the COMPERA registry","volume":"39","author":"Hoeper","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"2024102102434654000_59.6.2102334.11","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.6.473"},{"key":"2024102102434654000_59.6.2102334.12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00223611"},{"key":"2024102102434654000_59.6.2102334.13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00095804"},{"key":"2024102102434654000_59.6.2102334.14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/hc2901.093198","article-title":"Exercise pathophysiology in patients with primary pulmonary hypertension","volume":"104","author":"Sun","year":"2001","journal-title":"Circulation"},{"key":"2024102102434654000_59.6.2102334.15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ccm.2020.11.003","article-title":"The role of exercise testing in pulmonary vascular disease: diagnosis and management","volume":"42","author":"Systrom","year":"2021","journal-title":"Clin Chest Med"},{"key":"2024102102434654000_59.6.2102334.16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/cphy.c090014","article-title":"Pulmonary vascular diseases","volume":"1","author":"M\u00e9lot","year":"2011","journal-title":"Compr Physiol"},{"key":"2024102102434654000_59.6.2102334.17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00134506"},{"key":"2024102102434654000_59.6.2102334.18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.4.457"},{"key":"2024102102434654000_59.6.2102334.19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109542"},{"key":"2024102102434654000_59.6.2102334.20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.83.2.203"},{"key":"2024102102434654000_59.6.2102334.21","first-page":"412","article-title":"Pulmonary gas exchange during exercise in patients with chronic obliterative pulmonary hypertension","volume":"130","author":"Dantzker","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"2024102102434654000_59.6.2102334.22","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1108-6"},{"key":"2024102102434654000_59.6.2102334.23","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijcard.2017.11.023","article-title":"Physiological insights into exercise hyperventilation in arterial and chronic thromboembolic pulmonary hypertension","volume":"259","author":"Farina","year":"2018","journal-title":"Int J Cardiol"},{"key":"2024102102434654000_59.6.2102334.24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00137614"},{"key":"2024102102434654000_59.6.2102334.25","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02517-2017"},{"key":"2024102102434654000_59.6.2102334.26","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00342-2019"},{"key":"2024102102434654000_59.6.2102334.27","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00048514"},{"key":"2024102102434654000_59.6.2102334.28","doi-asserted-by":"publisher","DOI":"10.1378\/chest.89.1.39"},{"key":"2024102102434654000_59.6.2102334.29","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140724.90898.D3"},{"key":"2024102102434654000_59.6.2102334.30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1856OC"},{"key":"2024102102434654000_59.6.2102334.31","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00217911"},{"key":"2024102102434654000_59.6.2102334.32","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)90332-7"},{"key":"2024102102434654000_59.6.2102334.33","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s00134-003-1693-3","article-title":"Pulmonary vascular resistance: a meaningless variable?","volume":"29","author":"Naeije","year":"2003","journal-title":"Intens Care Med"},{"key":"2024102102434654000_59.6.2102334.34","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00091-6"},{"key":"2024102102434654000_59.6.2102334.35","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.72.6.1270"},{"key":"2024102102434654000_59.6.2102334.36","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.3.2106033"},{"key":"2024102102434654000_59.6.2102334.37","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00162.2004"},{"key":"2024102102434654000_59.6.2102334.38","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1152\/jappl.1992.73.3.987","article-title":"A simple distensible model for interpreting pulmonary vascular pressure-flow curves","volume":"73","author":"Linehan","year":"1992","journal-title":"J Appl Physiol"},{"key":"2024102102434654000_59.6.2102334.39","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201211-2090CI"},{"key":"2024102102434654000_59.6.2102334.40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000667"},{"key":"2024102102434654000_59.6.2102334.41","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0125"},{"key":"2024102102434654000_59.6.2102334.42","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.chest.2019.04.111","article-title":"Pulmonary vascular distensibility and early pulmonary vascular remodeling in pulmonary hypertension","volume":"156","author":"Singh","year":"2019","journal-title":"Chest"},{"key":"2024102102434654000_59.6.2102334.43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.003011"},{"key":"2024102102434654000_59.6.2102334.44","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1164\/rccm.201801-0081PP","article-title":"Hematocrit-corrected pulmonary vascular resistance","volume":"198","author":"Vanderpool","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102434654000_59.6.2102334.45","first-page":"H817","article-title":"Starling","volume":"267","author":"M\u00e9lot","year":"1995","journal-title":"Am J Physiol"},{"key":"2024102102434654000_59.6.2102334.46","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00054202"},{"key":"2024102102434654000_59.6.2102334.47","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000111841.28126.D4"},{"key":"2024102102434654000_59.6.2102334.48","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00134111"},{"key":"2024102102434654000_59.6.2102334.49","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.041515"},{"key":"2024102102434654000_59.6.2102334.50","first-page":"389","article-title":"Pulmonary artery adventitial changes and venous involvement in primary pulmonary hypertension","volume":"146","author":"Chazova","year":"1995","journal-title":"Am J Pathol"},{"key":"2024102102434654000_59.6.2102334.51","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(88)90261-6"},{"key":"2024102102434654000_59.6.2102334.52","doi-asserted-by":"publisher","DOI":"10.1007\/BF02368506"},{"key":"2024102102434654000_59.6.2102334.53","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.674028"},{"key":"2024102102434654000_59.6.2102334.54","first-page":"H197","article-title":"Effects of blood volume changes on characteristic impedance of the pulmonary artery","volume":"242","author":"Dujardin","year":"1982","journal-title":"Am J Physiol"},{"key":"2024102102434654000_59.6.2102334.55","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90682-Q"},{"key":"2024102102434654000_59.6.2102334.56","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.6.2121"},{"key":"2024102102434654000_59.6.2102334.57","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309906"},{"key":"2024102102434654000_59.6.2102334.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.08.014"},{"key":"2024102102434654000_59.6.2102334.59","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/25.2.118"},{"key":"2024102102434654000_59.6.2102334.60","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.62.1.105"},{"key":"2024102102434654000_59.6.2102334.61","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00054-5"},{"key":"2024102102434654000_59.6.2102334.62","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01212-2"},{"key":"2024102102434654000_59.6.2102334.63","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.2.302"},{"key":"2024102102434654000_59.6.2102334.64","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1183\/09031936.95.08091445","article-title":"More on the noninvasive diagnosis of pulmonary hypertension: Doppler echocardiography revisited","volume":"8","author":"Naeije","year":"1995","journal-title":"Eur Respir J"},{"key":"2024102102434654000_59.6.2102334.65","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl534"},{"key":"2024102102434654000_59.6.2102334.66","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm040"},{"key":"2024102102434654000_59.6.2102334.67","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201004-0601OC"},{"key":"2024102102434654000_59.6.2102334.68","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00694.2009"},{"key":"2024102102434654000_59.6.2102334.69","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00002210"},{"key":"2024102102434654000_59.6.2102334.70","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.29.1.40"},{"key":"2024102102434654000_59.6.2102334.71","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00336.2006"},{"key":"2024102102434654000_59.6.2102334.72","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn103"},{"key":"2024102102434654000_59.6.2102334.73","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0348"},{"key":"2024102102434654000_59.6.2102334.74","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200910-1643OC"},{"key":"2024102102434654000_59.6.2102334.75","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00033.2013"},{"key":"2024102102434654000_59.6.2102334.76","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00128.2013"},{"key":"2024102102434654000_59.6.2102334.77","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.051540"},{"key":"2024102102434654000_59.6.2102334.78","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00741-2015"},{"key":"2024102102434654000_59.6.2102334.79","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00174213"},{"key":"2024102102434654000_59.6.2102334.80","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-010-0027-1"},{"key":"2024102102434654000_59.6.2102334.81","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.chest.2018.12.006","article-title":"Golden ratio and the proportionality between pulmonary pressure components in pulmonary arterial hypertension","volume":"155","author":"Chemla","year":"2019","journal-title":"Chest"},{"key":"2024102102434654000_59.6.2102334.82","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.4.1313"},{"key":"2024102102434654000_59.6.2102334.83","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.4.657"},{"key":"2024102102434654000_59.6.2102334.84","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001375"},{"key":"2024102102434654000_59.6.2102334.85","unstructured":"Sagawa K , Maughan L , Suga H , et al. Cardiac Contraction and the Pressure\u2013Volume Relationship. New York, Oxford University Press, 1988."},{"key":"2024102102434654000_59.6.2102334.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.076"},{"key":"2024102102434654000_59.6.2102334.87","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.32.3.314"},{"key":"2024102102434654000_59.6.2102334.88","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.44.3.309"},{"key":"2024102102434654000_59.6.2102334.89","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01023.2002"},{"key":"2024102102434654000_59.6.2102334.90","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143138.02493.DD"},{"key":"2024102102434654000_59.6.2102334.91","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000008"},{"key":"2024102102434654000_59.6.2102334.92","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01123.2013"},{"key":"2024102102434654000_59.6.2102334.93","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2271OC"},{"key":"2024102102434654000_59.6.2102334.94","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022082"},{"key":"2024102102434654000_59.6.2102334.95","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1164\/rccm.201906-1195LE","article-title":"Evaluation and prognostic relevance of right ventricular-arterial coupling in pulmonary hypertension","volume":"201","author":"Richter","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102434654000_59.6.2102334.96","doi-asserted-by":"crossref","first-page":"e005512","DOI":"10.1161\/CIRCHEARTFAILURE.118.005512","article-title":"Reserve of right ventricular-arterial coupling in the setting of chronic overload","volume":"12","author":"Tello","year":"2019","journal-title":"Circ Heart Fail"},{"key":"2024102102434654000_59.6.2102334.97","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1164\/rccm.202003-0807LE","article-title":"Sex differences in right ventriculo-arterial coupling in pulmonary arterial hypertension","volume":"202","author":"Tello","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102434654000_59.6.2102334.98","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.63.1.45"},{"key":"2024102102434654000_59.6.2102334.99","doi-asserted-by":"crossref","first-page":"L715","DOI":"10.1152\/ajplung.00583.2020","article-title":"Right ventricular pressure\u2013volume loop shape and systolic pressure change in pulmonary hypertension","volume":"320","author":"Richter","year":"2021","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2024102102434654000_59.6.2102334.100","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300462"},{"key":"2024102102434654000_59.6.2102334.101","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306142"},{"key":"2024102102434654000_59.6.2102334.102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.08.138"},{"key":"2024102102434654000_59.6.2102334.103","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.022"},{"key":"2024102102434654000_59.6.2102334.104","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01635-2019"},{"key":"2024102102434654000_59.6.2102334.105","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02341-2019"},{"key":"2024102102434654000_59.6.2102334.106","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.6.1203"},{"key":"2024102102434654000_59.6.2102334.107","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1164\/rccm.201802-0283LE","article-title":"More on single beat estimation of right ventriculoarterial coupling in pulmonary arterial hypertension","volume":"198","author":"Tello","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102434654000_59.6.2102334.108","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-11"},{"key":"2024102102434654000_59.6.2102334.109","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.05.015"},{"key":"2024102102434654000_59.6.2102334.110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.068"},{"key":"2024102102434654000_59.6.2102334.111","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1164\/rccm.201909-1771OC","article-title":"Identification of cardiac magnetic resonance imaging thresholds for risk stratification in pulmonary arterial hypertension","volume":"201","author":"Lewis","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102434654000_59.6.2102334.112","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jcmg.2020.08.013","article-title":"Cardiac-MRI predicts clinical worsening and mortality in pulmonary arterial hypertension: a systematic review and meta-analysis","volume":"14","author":"Alabed","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"2024102102434654000_59.6.2102334.113","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.chest.2016.07.036","article-title":"Echocardiography combined with cardiopulmonary exercise testing for the prediction of outcome in idiopathic pulmonary arterial hypertension","volume":"150","author":"Badagliacca","year":"2016","journal-title":"Chest"},{"key":"2024102102434654000_59.6.2102334.114","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.healun.2017.09.026","article-title":"Prognostic relevance of right heart reverse remodeling in idiopathic pulmonary arterial hypertension","volume":"37","author":"Badagliacca","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"2024102102434654000_59.6.2102334.115","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00007-2017"},{"key":"2024102102434654000_59.6.2102334.116","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.healun.2017.08.009","article-title":"Influence of various therapeutic strategies on right ventricular morphology, function and hemodynamics in pulmonary arterial hypertension","volume":"37","author":"Badagliacca","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"2024102102434654000_59.6.2102334.117","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.chest.2019.09.009","article-title":"Risk reduction and right heart reverse remodeling by upfront triple combination therapy in pulmonary arterial hypertension","volume":"157","author":"D'Alto","year":"2020","journal-title":"Chest"},{"key":"2024102102434654000_59.6.2102334.118","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001873"},{"key":"2024102102434654000_59.6.2102334.119","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00156714"},{"key":"2024102102434654000_59.6.2102334.120","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00764-2017"},{"key":"2024102102434654000_59.6.2102334.121","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/cvr\/cvx160","article-title":"The overloaded right ventricle and ventricular interdependence","volume":"113","author":"Naeije","year":"2017","journal-title":"Cardiovasc Res"},{"key":"2024102102434654000_59.6.2102334.122","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.3.546"},{"key":"2024102102434654000_59.6.2102334.123","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/25.9.774"},{"key":"2024102102434654000_59.6.2102334.124","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm567"},{"key":"2024102102434654000_59.6.2102334.125","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01496-6"},{"key":"2024102102434654000_59.6.2102334.126","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.478"},{"key":"2024102102434654000_59.6.2102334.127","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.041"},{"key":"2024102102434654000_59.6.2102334.128","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jcmg.2015.02.009","article-title":"Right intraventricular dyssynchrony in idiopathic, heritable, and anorexigen-induced pulmonary arterial hypertension: clinical impact and reversibility","volume":"6","author":"Badagliacca","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"2024102102434654000_59.6.2102334.129","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s10554-017-1110-6","article-title":"Altered synchrony of right ventricular contraction in borderline pulmonary hypertension","volume":"33","author":"Lamia","year":"2017","journal-title":"Int J Cardiovasc Imaging"},{"key":"2024102102434654000_59.6.2102334.130","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001573"},{"key":"2024102102434654000_59.6.2102334.131","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft044"},{"key":"2024102102434654000_59.6.2102334.132","doi-asserted-by":"crossref","first-page":"2045894019862435","DOI":"10.1177\/2045894019862435","article-title":"Dynamic right ventricular-pulmonary uncoupling during maximal incremental exercise in exercise pulmonary hypertension and pulmonary arterial hypertension","volume":"9","author":"Singh","year":"2019","journal-title":"Pulm Circ"},{"key":"2024102102434654000_59.6.2102334.133","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-2-234"},{"key":"2024102102434654000_59.6.2102334.134","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00089914"},{"key":"2024102102434654000_59.6.2102334.135","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00081314"},{"key":"2024102102434654000_59.6.2102334.136","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00157.2013"},{"key":"2024102102434654000_59.6.2102334.137","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.12.024"},{"key":"2024102102434654000_59.6.2102334.138","doi-asserted-by":"crossref","first-page":"e009047","DOI":"10.1161\/CIRCIMAGING.119.009047","article-title":"Validation of the tricuspid annular plane systolic excursion\/systolic pulmonary artery pressure ratio for the assessment of right ventricular-arterial coupling in severe pulmonary hypertension","volume":"12","author":"Tello","year":"2019","journal-title":"Circ Cardiovasc Imaging"},{"key":"2024102102434654000_59.6.2102334.139","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijcard.2018.01.053","article-title":"Relevance of the TAPSE\/PASP ratio in pulmonary arterial hypertension","volume":"266","author":"Tello","year":"2018","journal-title":"Int J Cardiol"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.02334-2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:52:23Z","timestamp":1740358343000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.02334-2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,4]]},"references-count":139,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,16]]},"published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1183\/13993003.02334-2021"],"URL":"https:\/\/doi.org\/10.1183\/13993003.02334-2021","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,4]]}}}