{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:42:37Z","timestamp":1773344557397,"version":"3.50.1"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publications.ersnet.org\/user-licence"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["108-2314-B-002-193-, 110-2314-B-002-258-MY3"],"award-info":[{"award-number":["108-2314-B-002-193-, 110-2314-B-002-258-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2025,10,28]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transthoracic shear-wave elastography (SWE) facilitates differentiation between benign and malignant lesions. This pragmatic randomised controlled trial aimed to validate the effectiveness and safety of SWE-guided transthoracic biopsy for diagnosing subpleural lung lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible patients with peripheral lung lesions suspicious for lung malignancy and suitable for biopsy were randomised in a 1:1 ratio to the SWE-guided or conventional ultrasound-guided transthoracic biopsy groups. Rapid on-site cytological evaluations were performed to guide adjustments to biopsy target areas. The primary outcome was the diagnostic yield, defined as the proportion of biopsies yielding a specific benign or malignant diagnosis on cytology or histology. Secondary outcomes included biopsy duration and the combined incidence of post-biopsy complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From May 2019 to June 2023, a total of 413 patients were randomised. Ultimately, 205 patients in the SWE group and 206 in the conventional group were included in the intention-to-diagnose analysis. The SWE group achieved a significantly higher diagnostic yield compared with the conventional group (94.6%\n                      <jats:italic>versus<\/jats:italic>\n                      88.3%; risk ratio 1.07, 95% CI 1.01\u20131.14; p=0.02) and a shorter biopsy duration (median (interquartile range) 12 (9\u201315)\n                      <jats:italic>versus<\/jats:italic>\n                      13 (10\u201318)\u2005min; Hodges\u2013Lehmann median difference \u22121.0 (95% CI \u22123.0\u20130)\u2005min; p=0.003). The combined incidence of pneumothorax, haemoptysis and haemothorax was comparable between the groups (2.4%\n                      <jats:italic>versus<\/jats:italic>\n                      2.9%; risk ratio 0.84, 95% CI 0.26\u20132.70; p=0.77).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SWE-guided transthoracic biopsy increased the diagnostic yield and reduced the biopsy duration for subpleural lung lesions without increasing the risk of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.02370-2024","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:00:32Z","timestamp":1762452032000},"page":"2402370","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Shear-wave elastography-guided transthoracic biopsy for 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