{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:05:24Z","timestamp":1791439524546,"version":"4.3.3"},"reference-count":16,"publisher":"European Respiratory Society (ERS)","issue":"1","funder":[{"name":"The Chest Foundation\/Pulmonary Fibrosis Foundation","award":["2013 Clinical Research Grant in Pulmonary Fibrosis"],"award-info":[{"award-number":["2013 Clinical Research Grant in Pulmonary Fibrosis"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,3,21]]},"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>The objective of this study was to investigate the reliability, feasibility and analytical impact of home-based measurement of forced vital capacity (FVC) and dyspnoea as clinical endpoints in idiopathic pulmonary fibrosis (IPF).<\/jats:p>\n                  <jats:p>Patients with IPF performed weekly home-based assessment of FVC and dyspnoea using a mobile hand-held spirometer and self-administered dyspnoea questionnaires. Weekly variability in FVC and dyspnoea was estimated, and sample sizes were simulated for a hypothetical 24-week clinical trial using either traditional office-based interval measurement or mobile weekly assessment.<\/jats:p>\n                  <jats:p>In total, 25 patients were enrolled. Mean adherence to weekly assessments over 24\u2005weeks was greater than 90%. Compared with change assessment using baseline and 24-week measurements only, weekly assessment of FVC resulted in enhanced precision and power. For example, a hypothetical 24-week clinical trial with FVC as the primary endpoint would require 951 patients using weekly home spirometry compared with 3840 patients using office spirometry measures at weeks 1 and 24 only. The ability of repeated measures to reduce clinical trial sample size was influenced by the correlation structure of the data.<\/jats:p>\n                  <jats:p>Home monitoring can improve the precision of endpoint assessments, allowing for greater efficiency in clinical trials of therapeutics for IPF.<\/jats:p>","DOI":"10.1183\/13993003.02406-2016","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T21:10:25Z","timestamp":1499289025000},"page":"1602406","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":82,"title":["Home monitoring improves endpoint efficiency in idiopathic pulmonary fibrosis"],"prefix":"10.1183","volume":"50","author":[{"given":"Kerri A.","family":"Johannson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vittinghoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Morisset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0R.","family":"Balmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold R.","family":"Collard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2017,7,5]]},"reference":[{"key":"2024101904155406000_50.1.1602406.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"2024101904155406000_50.1.1602406.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0894CI"},{"key":"2024101904155406000_50.1.1602406.3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-12_Part_1-200506210-00005"},{"key":"2024101904155406000_50.1.1602406.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402584"},{"key":"2024101904155406000_50.1.1602406.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402582"},{"key":"2024101904155406000_50.1.1602406.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1500526"},{"key":"2024101904155406000_50.1.1602406.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0608"},{"key":"2024101904155406000_50.1.1602406.8","doi-asserted-by":"crossref","unstructured":"Vittinghoff EGD , Shiboski SC , McCulloch CE . 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