{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:00:26Z","timestamp":1790740826634,"version":"4.1.0"},"reference-count":39,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2018,2,26]]},"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Sleep is markedly altered in intensive care unit (ICU) patients and may alter respiratory performance. Our objective was to assess the impact of sleep alterations on weaning duration.<\/jats:p>\n                  <jats:p>We conducted a prospective physiological study at a French teaching hospital. ICU patients intubated for at least 24\u2005h and difficult to wean were included. Complete polysomnography (PSG) was performed after the first spontaneous breathing trial failure. Presence of atypical sleep, duration of sleep stages, particularly rapid eye movement (REM) sleep, and electroencephalogram (EEG) reactivity at eyes opening were assessed by a neurologist.<\/jats:p>\n                  <jats:p>\n                    20 out of 45 patients studied (44%) had atypical sleep that could not be classified according to the standard criteria. Duration of weaning between PSG and extubation was significantly longer in patients with atypical sleep (median (interquartile range) 5 (2\u20138)\n                    <jats:italic>versus<\/jats:italic>\n                    2 (1\u20132)\u2005days; p=0.001) and in those with no REM sleep compared with the others. Using multivariate logistic regression analysis, atypical sleep remained independently associated with prolonged weaning (&gt;48\u2005h after PSG). Altered EEG reactivity at eyes opening was a good predictor of atypical sleep.\n                  <\/jats:p>\n                  <jats:p>Our results suggest for the first time that brain dysfunction may have an influence on the ability to breathe spontaneously.<\/jats:p>","DOI":"10.1183\/13993003.02465-2017","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T20:10:15Z","timestamp":1520539815000},"page":"1702465","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":67,"title":["Impact of sleep alterations on weaning duration in mechanically ventilated patients: a prospective study"],"prefix":"10.1183","volume":"51","author":[{"given":"Arnaud 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