{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:46:23Z","timestamp":1775976383485,"version":"3.50.1"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,2,26]]},"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>The traceability of asbestos fibres in human lungs is a matter of discussion especially for chrysotile. This issue is of high significance for differential diagnosis, risk assessment and occupational compensation. At present no intra-individual longitudinal information is available. This study addresses the question whether the asbestos fibre burden in human lungs decreases with time after exposure cessation.<\/jats:p><jats:p>The database of the German Mesothelioma Register was screened for patients with asbestos body counts of at least 500 fibres per gram of wet lung, which had been analysed twice from different tissue excisions at minimum intervals of 4\u2005years.<\/jats:p><jats:p>Twelve datasets with individual longitudinal information were discovered with a median interval of about 8\u2005years (range 4\u201321 years). Both examinations were performed after exposure cessation (median: surgery, 9.5 years; autopsy, 22 years). Pulmonary asbestos fibre burden was stable between both examinations (median 1623\/4269 asbestos bodies per gram wet lung). Electron microscopy demonstrated a preponderance of chrysotile (median 80%).<\/jats:p><jats:p>This study is the first to present longitudinal intra-individual data about the asbestos fibre burden in living human lungs. The high biopersistence of amphiboles, but also of chrysotile, offers mechanistic explanations for fibre toxicity, especially the long latency period of asbestos-related diseases.<\/jats:p>","DOI":"10.1183\/13993003.02534-2016","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:10:15Z","timestamp":1498781415000},"page":"1602534","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":50,"title":["The asbestos fibre burden in human lungs: new insights into the chrysotile\u00a0debate"],"prefix":"10.1183","volume":"49","author":[{"given":"Inke Sabine","family":"Feder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Tischoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Theile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Merget","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Tannapfel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"2024101903573310000_49.6.1602534.1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2015-103074"},{"key":"2024101903573310000_49.6.1602534.2","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ajim.22430","article-title":"Significant relationship between the extent of pleural plaques and pulmonary asbestos body concentration in lung cancer patients with occupational asbestos exposure","volume":"58","author":"Yusa","year":"2015","journal-title":"Am J Ind Med"},{"key":"2024101903573310000_49.6.1602534.3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/his.12951","article-title":"Usual interstitial pneumonia in asbestos-exposed cohorts \u2013 concurrent idiopathic pulmonary fibrosis or atypical asbestosis?","volume":"69","author":"Attanoos","year":"2016","journal-title":"Histopathology"},{"key":"2024101903573310000_49.6.1602534.4","first-page":"327","article-title":"Lung dust content in idiopathic pulmonary fibrosis: a study with scanning electron microscopy and energy dispersive x ray analysis","volume":"48","author":"Mons\u00f3","year":"1991","journal-title":"Br J Ind Med"},{"key":"2024101903573310000_49.6.1602534.5","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.226"},{"key":"2024101903573310000_49.6.1602534.6","doi-asserted-by":"crossref","first-page":"462","DOI":"10.5858\/134.3.462","article-title":"Pathology of asbestosis: an update of the diagnostic criteria. 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