{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:55:18Z","timestamp":1790042118055,"version":"4.0.1"},"reference-count":26,"publisher":"European Respiratory Society (ERS)","issue":"5","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2020,8,27]]},"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pneumothorax and pneumomediastinum have both been noted to complicate cases of coronavirus disease 2019 (COVID-19) requiring hospital admission. We report the largest case series yet described of patients with both these pathologies (including nonventilated patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases were collected retrospectively from UK hospitals with inclusion criteria limited to a diagnosis of COVID-19 and the presence of either pneumothorax or pneumomediastinum. Patients included in the study presented between March and June 2020. Details obtained from the medical record included demographics, radiology, laboratory investigations, clinical management and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>71 patients from 16 centres were included in the study, of whom 60 had pneumothoraces (six with pneumomediastinum in addition) and 11 had pneumomediastinum alone. Two of these patients had two distinct episodes of pneumothorax, occurring bilaterally in sequential fashion, bringing the total number of pneumothoraces included to 62. Clinical scenarios included patients who had presented to hospital with pneumothorax, patients who had developed pneumothorax or pneumomediastinum during their inpatient admission with COVID-19 and patients who developed their complication while intubated and ventilated, either with or without concurrent extracorporeal membrane oxygenation. Survival at 28\u2005days was not significantly different following pneumothorax (63.1\u00b16.5%) or isolated pneumomediastinum (53.0\u00b118.7%; p=0.854). The incidence of pneumothorax was higher in males. 28-day survival was not different between the sexes (males 62.5\u00b17.7%<jats:italic>versus<\/jats:italic>females 68.4\u00b110.7%; p=0.619). Patients aged \u226570 years had a significantly lower 28-day survival than younger individuals (\u226570\u2005years 41.7\u00b113.5% survival<jats:italic>versus<\/jats:italic>&lt;70\u2005years 70.9\u00b16.8% survival; p=0.018 log-rank).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These cases suggest that pneumothorax is a complication of COVID-19. Pneumothorax does not seem to be an independent marker of poor prognosis and we encourage continuation of active treatment where clinically possible.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.02697-2020","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T04:25:32Z","timestamp":1599711932000},"page":"2002697","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":256,"title":["COVID-19 and pneumothorax: a multicentre retrospective case series"],"prefix":"10.1183","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7285-7498","authenticated-orcid":false,"given":"Anthony 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Management of persistent pneumothorax with thoracoscopy and blebs resection in COVID-19 patients. Ann Thorac Surg 2020: S0003-4975(20)30604-4."},{"key":"2024102102000576000_56.5.2002697.20","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136986"},{"key":"2024102102000576000_56.5.2002697.21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1985"},{"key":"2024102102000576000_56.5.2002697.22","unstructured":"Intensive Care National Audit & Research Centre (ICNARC) . Report on COVID-19 in Critical Care \u2013 03 July 2020 Date last updated: July 3, 2020. 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Available from: www.brit-thoracic.org.uk\/about-us\/covid-19-information-for-the-respiratory-community\/#guidance-on-pleural-services-during-covid-19-pandemic Date last updated: May 21, 2020. 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