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Individuals with either strong clinical suspicion or nNO \u226477\u2005nL\u00b7min\n                      <jats:sup>\u22121<\/jats:sup>\n                      received a structured diagnostic work-up, including transmission electron microscopy and whole-exome sequencing. Diagnoses followed the 2025 European Respiratory Society\/American Thoracic Society PCD diagnostic guidelines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 373 patients with bronchiectasis, 27 (7.4%) were in the PCD group (14 \u201cconfirmed PCD\u201d and 13 \u201cPCD highly likely\u201d). nNO showed high screening accuracy (sensitivity 84.8%, specificity 97.1%). Patients with PCD were younger and had earlier bronchiectasis onset. Age-adjusted regression analysis showed independent associations between PCD and lower body mass index (regression coefficient (RC) \u22121.5, 95% CI \u22122.9 to \u22120.1), forced expiratory volume in 1\u2005s (FEV\n                      <jats:sub>1<\/jats:sub>\n                      ) % predicted (RC \u221218.4, 95% CI \u221228.3 to \u22128.6), forced vital capacity (FVC) % predicted (RC \u221211.3, 95% CI \u221219.5 to \u22123.0), and FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC (RC \u221210.3, 95% CI \u221216.9 to \u22123.8). Strong associations were observed with rhinosinusitis (OR 25.3, 95% CI 8.8 to 92.1) and\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      infection (OR 8.5, 95% CI 3.2 to 25.7). Situs inversus occurred in 25.9% of patients with PCD.\n                      <jats:italic>DNAH11<\/jats:italic>\n                      was the most common pathogenic gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with PCD had more severe disease, reinforcing the need for structured screening in patients with bronchiectasis. nNO combined with clinical features is an effective and reliable screening strategy for PCD in bronchiectasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.02796-2025","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:39:39Z","timestamp":1778769579000},"page":"2502796","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nasal nitric oxide combined with clinical features for preliminary 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