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We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background.<\/jats:p>\n                  <jats:p>We conducted the first large-scale genome-wide association study of OSA using the FinnGen study (217\u200a955 individuals) with 16\u200a761 OSA patients identified using nationwide health registries.<\/jats:p>\n                  <jats:p>\n                    We estimated 0.08 (95% CI 0.06\u20130.11) heritability and identified five loci associated with OSA (p&lt;5.0\u00d710\n                    <jats:sup>\u22128<\/jats:sup>\n                    ): rs4837016 near\n                    <jats:italic>GAPVD1<\/jats:italic>\n                    (GTPase activating protein and VPS9 domains 1), rs10928560 near\n                    <jats:italic>CXCR4<\/jats:italic>\n                    (C-X-C motif chemokine receptor type 4), rs185932673 near\n                    <jats:italic>CAMK1D<\/jats:italic>\n                    (calcium\/calmodulin-dependent protein kinase ID) and rs9937053 near\n                    <jats:italic>FTO<\/jats:italic>\n                    (fat mass and obesity-associated protein; a variant previously associated with body mass index (BMI)). In a BMI-adjusted analysis, an association was observed for rs10507084 near\n                    <jats:italic>RMST<\/jats:italic>\n                    \/\n                    <jats:italic>NEDD1<\/jats:italic>\n                    (rhabdomyosarcoma 2 associated transcript\/NEDD1 \u03b3-tubulin ring complex targeting factor). We found high genetic correlations between OSA and BMI (r\n                    <jats:sub>g<\/jats:sub>\n                    =0.72 (95% CI 0.62\u20130.83)), and with comorbidities including hypertension, type 2 diabetes, coronary heart disease, stroke, depression, hypothyroidism, asthma and inflammatory rheumatic disease (r\n                    <jats:sub>g<\/jats:sub>\n                    &gt;0.30). The polygenic risk score for BMI showed 1.98-fold increased OSA risk between the highest and the lowest quintile, and Mendelian randomisation supported a causal relationship between BMI and OSA.\n                  <\/jats:p>\n                  <jats:p>Our findings support the causal link between obesity and OSA, and the joint genetic basis between OSA and comorbidities.<\/jats:p>","DOI":"10.1183\/13993003.03091-2020","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T17:10:18Z","timestamp":1606410618000},"page":"2003091","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":174,"title":["Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic 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