{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:28:45Z","timestamp":1779269325381,"version":"3.51.4"},"reference-count":33,"publisher":"European Respiratory Society (ERS)","issue":"5","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"funder":[{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","award":["CRC-2013-03"],"award-info":[{"award-number":["CRC-2013-03"]}],"id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["115721"],"award-info":[{"award-number":["115721"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2020,11,5]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Existing quality-of-life and symptom tools used in bronchiectasis trials are either not disease specific or are complex and have not been consistently responsive. We developed a simple patient-reported visual analogue outcome measure, the Bronchiectasis Impact Measure (BIM), for use in clinical research, including clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with bronchiectasis attending a tertiary referral clinic in the east of Scotland were invited to complete the BIM questionnaire and the quality-of-life bronchiectasis questionnaire at baseline with repeat questionnaires after 2\u2005weeks and 6\u2005months. We assessed internal consistency, test\u2013retest reliability, construct validity and responsiveness by evaluating change during an acute exacerbation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>173 patients were included. The eight domains (cough, sputum, breathlessness, tiredness, activity, general health, control, exacerbations) showed excellent internal consistency (Cronbach's \u03b1 0.93). The intraclass correlation coefficient demonstrated excellent reliability over a 2-week period: cough (0.79, 95% CI 0.70\u20130.85), sputum (0.86, 95% CI 0.80\u20130.90), dyspnoea (0.82, 95% CI 0.74\u20130.87), tiredness (0.88, 95% CI 0.82\u20130.91), activity (0.84, 95% CI 0.77\u20130.89), general health (0.81, 95% CI 0.74\u20130.87), control (0.83, 95% CI 0.75\u20130.88) and exacerbation (0.71, 95% CI 0.60\u20130.79). Domains correlated strongly with bronchiectasis severity and exacerbation history. Both distribution and patient-based methods estimated the minimal clinically important difference for each domain as 1.5 points on a 10-point scale. Statistically significant changes in all BIM domains were observed during an acute exacerbation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The BIM is a simple patient-reported outcome. This study validates the internal consistency, reliability, construct validity and response of the tool at acute exacerbation. Further validation of the tool is now required.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.03156-2020","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T23:57:30Z","timestamp":1605830250000},"page":"2003156","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Validation of the Bronchiectasis Impact Measure (BIM): a novel patient-reported outcome measure"],"prefix":"10.1183","volume":"57","author":[{"given":"Megan L.","family":"Crichton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily K.","family":"Dudgeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-6060","authenticated-orcid":false,"given":"Amelia","family":"Shoemark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"2024102102082169000_57.5.2003156.1","unstructured":"US Food and Drug Administration . Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims. 2009. www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/patient-reported-outcome-measures-use-medical-product-development-support-labeling-claims Date last accessed: March 2, 2020."},{"key":"2024102102082169000_57.5.2003156.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.2.9607083"},{"key":"2024102102082169000_57.5.2003156.3","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.chest.2019.10.030","article-title":"Validation of the COPD Assessment Test (CAT) as an outcome measure in bronchiectasis","volume":"157","author":"Finch","year":"2020","journal-title":"Chest"},{"key":"2024102102082169000_57.5.2003156.4","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205918"},{"key":"2024102102082169000_57.5.2003156.5","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01532-2016"},{"key":"2024102102082169000_57.5.2003156.6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00160508"},{"key":"2024102102082169000_57.5.2003156.7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000430992","article-title":"Validity and reliability of the chronic respiratory disease questionnaire in elderly individuals with mild to moderate non-cystic fibrosis bronchiectasis","volume":"90","author":"Vodanovich","year":"2015","journal-title":"Respiration"},{"key":"2024102102082169000_57.5.2003156.8","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0108-2018"},{"key":"2024102102082169000_57.5.2003156.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.12.021"},{"key":"2024102102082169000_57.5.2003156.10","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S2213-2600(19)30185-7","article-title":"The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis","volume":"7","author":"Laska","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2024102102082169000_57.5.2003156.11","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02052-2017"},{"key":"2024102102082169000_57.5.2003156.12","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02053-2017"},{"key":"2024102102082169000_57.5.2003156.13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12890-019-0856-0","article-title":"Pulmonary rehabilitation after exacerbation of bronchiectasis: a pilot randomized controlled trial","volume":"19","author":"Chalmers","year":"2019","journal-title":"BMC Pulm Med"},{"key":"2024102102082169000_57.5.2003156.14","first-page":"CD008351","article-title":"Airway clearance techniques for bronchiectasis","volume":"2015","author":"Lee","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2024102102082169000_57.5.2003156.15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12890-018-0631-7","article-title":"\u201cThe missing ingredient\u201d: the patient perspective of health related quality of life in bronchiectasis: a qualitative study","volume":"18","author":"Dudgeon","year":"2018","journal-title":"BMC Pulm Med"},{"key":"2024102102082169000_57.5.2003156.16","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01888-2015"},{"key":"2024102102082169000_57.5.2003156.17","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04341"},{"key":"2024102102082169000_57.5.2003156.18","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1164\/rccm.201711-2202OC","article-title":"Characterization of the \u201cfrequent exacerbator phenotype\u201d in bronchiectasis","volume":"197","author":"Chalmers","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102102082169000_57.5.2003156.19","unstructured":"US Food and Drug Administration . Draft Guidance for Industry on Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims; Availability. Federal Register. 2006. www.federalregister.gov\/documents\/2006\/02\/03\/E6-1433\/draft-guidance-for-industry-on-patient-reported-outcome-measures-use-in-medical-product-development Date last accessed: June 3, 2019."},{"key":"2024102102082169000_57.5.2003156.20","doi-asserted-by":"publisher","DOI":"10.1187\/cbe.16-04-0148"},{"key":"2024102102082169000_57.5.2003156.21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2307\/2288670","article-title":"Rating scale analysis: Rasch measurement","volume":"78","author":"Wolins","year":"1983","journal-title":"J Am Stat Assoc"},{"key":"2024102102082169000_57.5.2003156.22","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201506-333OC"},{"key":"2024102102082169000_57.5.2003156.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.03.012"},{"key":"2024102102082169000_57.5.2003156.24","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200305000-00004"},{"key":"2024102102082169000_57.5.2003156.25","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00051-2017"},{"key":"2024102102082169000_57.5.2003156.26","unstructured":"NIH Central Resource for Grants and Funding Information . 2019. Patient Reported Outcomes Tool Development for Use in Non-Cystic Fibrosis Bronchiectasis Clinical Trials (U01 \u2013 Clinical Trial Required). https:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/rfa-fd-19-014.html Date last accessed: October 31, 2020."},{"key":"2024102102082169000_57.5.2003156.27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1575OC"},{"key":"2024102102082169000_57.5.2003156.28","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205587"},{"key":"2024102102082169000_57.5.2003156.29","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00608-2020"},{"key":"2024102102082169000_57.5.2003156.30","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.chest.2019.08.1916","article-title":"COPD Assessment Test in bronchiectasis: minimum clinically important difference and psychometric validation: a prospective study","volume":"157","author":"De la Rosa Carrillo","year":"2020","journal-title":"Chest"},{"key":"2024102102082169000_57.5.2003156.31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12955-017-0604-1","article-title":"Patient-defined desired outcome, success criteria, and expectation in outpatient physical therapy: a longitudinal assessment","volume":"15","author":"Zeppieri","year":"2017","journal-title":"Health Qual Life Outcomes"},{"key":"2024102102082169000_57.5.2003156.32","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/alr.22309","article-title":"Symptom importance, patient expectations, and satisfaction in chronic rhinosinusitis","volume":"9","author":"Mattos","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"key":"2024102102082169000_57.5.2003156.33","first-page":"557","article-title":"Minimum important difference between patients with rheumatoid arthritis: the patient's perspective","volume":"20","author":"Wells","year":"1993","journal-title":"J Rheumatol"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.03156-2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:41:42Z","timestamp":1740382902000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.03156-2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":33,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,27]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1183\/13993003.03156-2020"],"URL":"https:\/\/doi.org\/10.1183\/13993003.03156-2020","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,19]]}}}