{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:49:23Z","timestamp":1777495763741,"version":"3.51.4"},"reference-count":27,"publisher":"European Respiratory Society (ERS)","issue":"5","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"funder":[{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2020,10,26]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Obstructive sleep apnoea (OSA) is associated with an increased prevalence of aortic aneurysms and it has also been suggested that severe OSA furthers aneurysm expansion in the abdomen. We evaluated whether OSA is a risk factor for the progression of ascending thoracic aortic aneurysm (TAA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with TAA underwent yearly standardised echocardiographic measurements of the ascending aorta over 3\u2005years and two level III sleep studies. The primary outcome was the expansion rate of TAA in relation to the apnoea\u2013hypopnoea index (AHI). Secondary outcomes included surveillance for aortic events (composite end-points of rupture\/dissection, elective surgery or death).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between July 2014 and March 2020, 230 patients (median age 70\u2005years, 83.5% male) participated in the cohort. At baseline, 34.8% of patients had AHI \u226515\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>. There was no association between TAA diameter and AHI at baseline. After 3\u2005years, mean\u00b1<jats:sc>sd<\/jats:sc>expansion rates were 0.55\u00b11.25\u2005mm at the aortic sinus and 0.60\u00b11.12\u2005mm at the ascending aorta. In the regression analysis, after controlling for baseline diameter and cardiovascular risk factors, there was strong evidence for a positive association of TAA expansion with AHI (aortic sinus estimate 0.025\u2005mm, 95% CI 0.009\u20130.040\u2005mm; p&lt;0.001 and ascending aorta estimate 0.026\u2005mm, 95% CI 0.011\u20130.041\u2005mm; p=0.001). 20 participants (8%) experienced an aortic event; however, there was no association with OSA severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OSA may be a modest but independent risk factor for faster TAA expansion and thus potentially contributes to life-threatening complications in aortic disease.<\/jats:p><\/jats:sec>","DOI":"10.1183\/13993003.03322-2020","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T23:11:05Z","timestamp":1605827465000},"page":"2003322","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Obstructive sleep apnoea and the progression of thoracic aortic aneurysm: a prospective cohort 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