{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:49:38Z","timestamp":1787856578334,"version":"build-2784847793"},"reference-count":47,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"funder":[{"DOI":"10.13039\/501100002647","name":"Sungkyunkwan University","doi-asserted-by":"publisher","award":["SKKU Excellence in Research Award Research Fund"],"award-info":[{"award-number":["SKKU Excellence in Research Award Research Fund"]}],"id":[{"id":"10.13039\/501100002647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2021,2,22]]},"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The impact of blood eosinophil counts on the development of chronic obstructive lung disease (COPD) is unknown. We investigated whether a higher blood eosinophil count was associated with the risk of developing obstructive lung disease (OLD) in a large cohort of men and women free from lung disease at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a cohort study of 359\u200a456 Korean adults without a history of asthma and without OLD at baseline who participated in health screening examinations including spirometry. OLD was defined as pre-bronchodilator forced expiratory volume in 1\u2005s (FEV\n                      <jats:sub>1<\/jats:sub>\n                      )\/forced vital capacity (FVC) &lt;0.7 and FEV\n                      <jats:sub>1<\/jats:sub>\n                      &lt;80% predicted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After a median (interquartile range) follow-up of 5.6 (2.9\u20139.2)\u2005years, 5008 participants developed incident OLD (incidence rate 2.1 (95% CI 2.1\u20132.2) per 1000 person-years). In the fully adjusted model, the hazard ratios for incident OLD comparing eosinophil counts of 100\u2013\u200a&lt;200, 200\u2013\u200a&lt;300, 300\u2013\u200a&lt;500 and \u2265500\n                      <jats:italic>versus<\/jats:italic>\n                      &lt;100\u2005cells\u00b7\u03bcL\n                      <jats:sup>\u22121<\/jats:sup>\n                      were 1.07 (95% CI 1.00\u20131.15), 1.30 (95% CI 1.20\u20131.42), 1.46 (95% CI 1.33\u20131.60) and 1.72 (95% CI 1.51\u20131.95), respectively (p\n                      <jats:sub>trend<\/jats:sub>\n                      &lt;0.001). These associations were consistent in clinically relevant subgroups, including never-, ex- and current smokers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large longitudinal cohort study, blood eosinophil counts were positively associated with the risk of developing of OLD. Our findings indicate a potential role of the eosinophil count as an independent risk factor for developing COPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.03823-2020","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T10:00:16Z","timestamp":1616061616000},"page":"2003823","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["Blood eosinophil counts and the development of obstructive lung disease: the Kangbuk Samsung Health Study"],"prefix":"10.1183","volume":"58","author":[{"given":"Hye 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