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Understanding which characteristics of individual patients are associated with an increased risk for asthma exacerbation is a critical step to implement strategies preventing these seasonal events. Recent data suggest the possibility that exhaled volatile organic compounds may qualify as biomarkers in detecting early signs of asthma. Adding information of exhaled volatile organic compounds and expression of inflammation genes to a clinical tool significantly improves asthma prediction in preschool wheezy children. Personal communication with children and adolescents is likely more important than the tools actually used for monitoring asthma. Systemic corticosteroids do not affect the long-term prognosis in children with first viral-induced wheezing episode and should be used cautiously during acute episodes. Finally, stress and a polymorphism upstream of a specific gene are both associated with reduced bronchodilator response in children with asthma.<\/jats:p>","DOI":"10.1183\/16000617.0082-2015","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T20:57:47Z","timestamp":1456779467000},"page":"41-47","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":44,"title":["Asthma in childhood"],"prefix":"10.1183","volume":"25","author":[{"given":"Fernando Maria","family":"de 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