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Studies on rhinovirus species (RV)-C infection have found that this is associated with a decrease in expression of CDHR3, the cellular receptor specific for this virus, and a decrease in interferon-\u03b2 expression, both of which are likely to favour RV-C infection. Recent clinical trials in children have found a decrease in wheezing exacerbations with both anti-respiratory syncytial virus antibody and anti-immunoglobulin E antibody therapy, and a clinical trial of prednisolone in children with their first RV-induced wheeze showed that only those with an RV viral count &gt;7000\u2005copies\u00b7mL<jats:sup>\u22121<\/jats:sup>responded. Further studies on the effects of bacterial lysates on immune system function continue to support the potential of this approach to reduce virus-induced wheezing exacerbations in children. These studies and many previous investigations into immunomodulation using bacterial lysates have led to the funding and commencement of a large study in which long-term administration of a bacterial lysate in young children will be assessed for its ability to prevent asthma.<\/jats:p>","DOI":"10.1183\/16000617.0133-2017","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T15:15:36Z","timestamp":1522941336000},"page":"170133","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Viral infections in wheezing disorders"],"prefix":"10.1183","volume":"27","author":[{"given":"Peter","family":"Le Sou\u00ebf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,4,5]]},"reference":[{"key":"2024102403335182000_27.147.170133.1","unstructured":"Thompson SP . 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