{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:41:26Z","timestamp":1792532486553,"version":"4.5.0"},"reference-count":83,"publisher":"European Respiratory Society (ERS)","issue":"170","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir Rev"],"accepted":{"date-parts":[[2023,9,5]]},"published-print":{"date-parts":[[2023,12,31]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Reduced mobility is a central feature of COPD. Assessment of mobility outcomes that can be measured digitally (digital mobility outcomes (DMOs)) in daily life such as gait speed and steps per day is increasingly possible using devices such as pedometers and accelerometers, but the predictive value of these measures remains unclear in relation to key outcomes such as hospital admission and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We conducted a systematic review, nested within a larger scoping review by the MOBILISE-D consortium, addressing DMOs in a range of chronic conditions. Qualitative and quantitative analysis considering steps per day and gait speed and their association with clinical outcomes in COPD patients was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>21 studies (6076 participants) were included. Nine studies evaluated steps per day and 11 evaluated a measure reflecting gait speed in daily life. Negative associations were demonstrated between mortality risk and steps per day (per 1000 steps) (hazard ratio (HR) 0.81, 95% CI 0.75\u20130.88, p&lt;0.001), gait speed (&lt;0.80\u2005m\u00b7s<jats:sup>\u22121<\/jats:sup>) (HR 3.55, 95% CI 1.72\u20137.36, p&lt;0.001) and gait speed (per 1.0\u2005m\u00b7s<jats:sup>\u22121<\/jats:sup>) (HR 7.55, 95% CI 1.11\u201351.3, p=0.04). Fewer steps per day (per 1000) and slow gait speed (&lt;0.80\u2005m\u00b7s<jats:sup>\u22121<\/jats:sup>) were also associated with increased healthcare utilisation (HR 0.80, 95% CI 0.72\u20130.88, p&lt;0.001; OR 3.36, 95% CI 1.42\u20137.94, p=0.01, respectively). Available evidence was of low-moderate quality with few studies eligible for meta-analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Daily step count and gait speed are negatively associated with mortality risk and other important outcomes in people with COPD and therefore may have value as prognostic indicators in clinical trials, but the quantity and quality of evidence is limited. Larger studies with consistent methodologies are called for.<\/jats:p><\/jats:sec>","DOI":"10.1183\/16000617.0134-2023","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T10:17:21Z","timestamp":1700648241000},"page":"230134","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis"],"prefix":"10.1183","volume":"32","author":[{"given":"Sara C.","family":"Buttery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parris J.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed M.","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keir E.J.","family":"Philip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Kallis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-4869","authenticated-orcid":false,"given":"Jennifer K.","family":"Quint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Polkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-6923","authenticated-orcid":false,"given":"Sofie","family":"Breuls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4866-5741","authenticated-orcid":false,"given":"Joren","family":"Buekers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9595-6974","authenticated-orcid":false,"given":"Nikolaos","family":"Chynkiamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0311-7661","authenticated-orcid":false,"given":"Laura","family":"Delgado-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleen","family":"Demeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7134-1000","authenticated-orcid":false,"given":"Anja","family":"Frei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7097-4586","authenticated-orcid":false,"given":"Judith","family":"Garcia-Aymerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gimeno-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-4346","authenticated-orcid":false,"given":"Dimitrios","family":"Megaritis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Polhemus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Troosters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Vogiatzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Watz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-0454","authenticated-orcid":false,"given":"Nicholas S.","family":"Hopkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"2024102404164312000_32.170.230134.1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.gerinurse.2017.08.002","article-title":"The impact of mobility limitations on health outcomes among older adults","volume":"39","author":"Musich","year":"2018","journal-title":"Geriatr Nurs"},{"key":"2024102404164312000_32.170.230134.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016004235.x"},{"key":"2024102404164312000_32.170.230134.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1382"},{"key":"2024102404164312000_32.170.230134.4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.gaitpost.2016.09.026","article-title":"Gait deficits in people with multiple sclerosis: a systematic review and meta-analysis","volume":"51","author":"Comber","year":"2017","journal-title":"Gait Posture"},{"key":"2024102404164312000_32.170.230134.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.07.008"},{"key":"2024102404164312000_32.170.230134.6","doi-asserted-by":"crossref","first-page":"afac233","DOI":"10.1093\/ageing\/afac233","article-title":"Listening to the patients\u2019 voice: a conceptual framework of the walking experience","volume":"52","author":"Delgado-Ortiz","year":"2023","journal-title":"Age Ageing"},{"key":"2024102404164312000_32.170.230134.7","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.2147\/COPD.S170887","article-title":"Life-space mobility and clinical outcomes in COPD","volume":"13","author":"Iyer","year":"2018","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2024102404164312000_32.170.230134.8","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.060145"},{"key":"2024102404164312000_32.170.230134.9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/CS20090458","article-title":"Does physical inactivity cause chronic obstructive pulmonary disease?","volume":"118","author":"Hopkinson","year":"2010","journal-title":"Clin Sci (Lond)"},{"key":"2024102404164312000_32.170.230134.10","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204763"},{"key":"2024102404164312000_32.170.230134.11","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.2147\/COPD.S101459","article-title":"Depression symptoms reduce physical activity in COPD patients: a prospective multicenter study","volume":"11","author":"Duenas-Espin","year":"2016","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2024102404164312000_32.170.230134.12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/1479972316687207","article-title":"Physical activity patterns and clusters in 1001 patients with COPD","volume":"14","author":"Mesquita","year":"2017","journal-title":"Chron Respir Dis"},{"key":"2024102404164312000_32.170.230134.13","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.3390\/s140203362","article-title":"Gait analysis methods: an overview of wearable and non-wearable systems, highlighting clinical applications","volume":"14","author":"Muro-De-La-Herran","year":"2014","journal-title":"Sensors (Basel)"},{"key":"2024102404164312000_32.170.230134.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2011.03.024"},{"key":"2024102404164312000_32.170.230134.15","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2014"},{"key":"2024102404164312000_32.170.230134.16","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-9-86"},{"key":"2024102404164312000_32.170.230134.17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201209-1596OC"},{"key":"2024102404164312000_32.170.230134.18","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.081208"},{"key":"2024102404164312000_32.170.230134.19","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-211855"},{"key":"2024102404164312000_32.170.230134.20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00064105"},{"key":"2024102404164312000_32.170.230134.21","first-page":"PA3555","article-title":"Validity and usability of low-cost accelerometers for internet-based self-monitoring of physical activity in patients with COPD","volume":"46","author":"Vooijs","year":"2015","journal-title":"Eur Respir J"},{"key":"2024102404164312000_32.170.230134.22","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00541-2021"},{"key":"2024102404164312000_32.170.230134.23","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.chest.2021.12.657","article-title":"\u201cCan do, do do\u201d quadrants and 6-year all-cause mortality in patients with COPD","volume":"161","author":"Vaes","year":"2022","journal-title":"Chest"},{"key":"2024102404164312000_32.170.230134.24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41528-021-00107-x","article-title":"Advances in healthcare wearable devices","volume":"5","author":"Iqbal","year":"2021","journal-title":"NPJ Flex Electron"},{"key":"2024102404164312000_32.170.230134.25","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa138"},{"key":"2024102404164312000_32.170.230134.26","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00183014"},{"key":"2024102404164312000_32.170.230134.27","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-214554"},{"key":"2024102404164312000_32.170.230134.28","doi-asserted-by":"crossref","first-page":"e038704","DOI":"10.1136\/bmjopen-2020-038704","article-title":"Walking-related digital mobility outcomes as clinical trial endpoint measures: protocol for a scoping review","volume":"10","author":"Polhemus","year":"2020","journal-title":"BMJ Open"},{"key":"2024102404164312000_32.170.230134.29","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501-0081OC"},{"key":"2024102404164312000_32.170.230134.30","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1001\/jamasurg.2021.0522","article-title":"MOOSE reporting guidelines for meta-analyses of observational studies","volume":"156","author":"Brooke","year":"2021","journal-title":"JAMA Surg"},{"key":"2024102404164312000_32.170.230134.31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41746-021-00513-5","article-title":"Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes","volume":"4","author":"Polhemus","year":"2021","journal-title":"NPJ Digit Med"},{"key":"2024102404164312000_32.170.230134.32","unstructured":"Ryan R , Hill S . How to GRADE the quality of the evidence. Version 3.0. Cochrane Consumers and Communication Group. 2016. Available from https:\/\/cccrg.cochrane.org\/author-resources"},{"key":"2024102404164312000_32.170.230134.33","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jclinepi.2020.09.018","article-title":"GRADE guidelines 30: the GRADE approach to assessing the certainty of modeled evidence \u2013 an overview in the context of health decision-making","volume":"129","author":"Brozek","year":"2021","journal-title":"J Clin Epidemiol"},{"key":"2024102404164312000_32.170.230134.34","doi-asserted-by":"publisher","DOI":"10.1186\/s41512-019-0050-0"},{"key":"2024102404164312000_32.170.230134.35","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-4-201302190-00009"},{"key":"2024102404164312000_32.170.230134.36","unstructured":"Cochrane Group. CCPM: The Cochrane Collaboration Prognosis Methods Group. Review Tools. 2018. https:\/\/methods.cochrane.org\/prognosis\/tools Date last accessed: January 2023."},{"key":"2024102404164312000_32.170.230134.37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002742"},{"key":"2024102404164312000_32.170.230134.38","unstructured":"Raudenbush SW. Analysing effect sizes: random-effects models. In: The Handbook of Research Synthesis and Meta-Analysis. Cooper H , Hedges LV , Valentine JC , eds. 2nd edn. New York, Russell Sage Foundation, 2009, pp. 295\u2013316."},{"key":"2024102404164312000_32.170.230134.39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.rmed.2016.08.019","article-title":"A pilot study to monitor changes in spirometry and lung volume, following an exacerbation of chronic obstructive pulmonary disease (COPD), as part of a supported discharge program","volume":"119","author":"Cushen","year":"2016","journal-title":"Respir Med"},{"key":"2024102404164312000_32.170.230134.40","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1249\/MSS.0000000000001859","article-title":"Physical activity is associated with attenuated disease progression in chronic obstructive pulmonary disease","volume":"51","author":"Demeyer","year":"2019","journal-title":"Med Sci Sports Exerc"},{"key":"2024102404164312000_32.170.230134.41","first-page":"A233-A","article-title":"P262 Can we improve upon clinician prediction of survival in advanced COPD using clinically measurable prognostic factors?","volume":"74","author":"Jones","year":"2019","journal-title":"Thorax"},{"key":"2024102404164312000_32.170.230134.42","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207046"},{"key":"2024102404164312000_32.170.230134.43","doi-asserted-by":"crossref","first-page":"2040622320986718","DOI":"10.1177\/2040622320986718","article-title":"The five-repetition sit-to-stand test is a predictive factor of severe exacerbations in COPD","volume":"12","author":"Medina-Mirapeix","year":"2021","journal-title":"Ther Adv Chronic Dis"},{"key":"2024102404164312000_32.170.230134.44","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2016.0449"},{"key":"2024102404164312000_32.170.230134.45","first-page":"PA4698","article-title":"Association between number of steps and mortality in patients with severe chronic obstructive pulmonary disease","volume":"50","author":"Neumannova","year":"2017","journal-title":"Eur Respir J"},{"key":"2024102404164312000_32.170.230134.46","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2147\/COPD.S188710","article-title":"No impact of exacerbation frequency and severity on the physical activity decline in COPD: a long-term observation","volume":"14","author":"Sievi","year":"2019","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2024102404164312000_32.170.230134.47","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.04047-2020"},{"key":"2024102404164312000_32.170.230134.48","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2019.PA3414"},{"key":"2024102404164312000_32.170.230134.49","doi-asserted-by":"crossref","first-page":"611989","DOI":"10.3389\/fmed.2021.611989","article-title":"Weak handgrip at index admission for acute exacerbation of COPD predicts all-cause 30-day readmission","volume":"8","author":"Witt","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2024102404164312000_32.170.230134.50","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2521"},{"key":"2024102404164312000_32.170.230134.51","first-page":"A2284","article-title":"A2284. Association between exercise capacity and physical activity with long-term all-cause and cause-specific mortality among U.S. veterans with COPD","volume":"203","author":"Wan","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102404164312000_32.170.230134.52","first-page":"OA512","article-title":"The survival effect of physical activity in patients with COPD: every step counts","volume":"50","author":"Demeyer","year":"2017","journal-title":"Eur Respir J"},{"key":"2024102404164312000_32.170.230134.53","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.resinv.2021.03.008","article-title":"Correlation of 4-meter gait speed with clinical indicators of chronic obstructive pulmonary disease","volume":"59","author":"Nakano","year":"2021","journal-title":"Respir Investig"},{"key":"2024102404164312000_32.170.230134.54","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2018.PA3859"},{"key":"2024102404164312000_32.170.230134.55","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/1099800418772346","article-title":"Mortality in advanced chronic obstructive pulmonary disease and heart failure following cardiopulmonary rehabilitation","volume":"20","author":"Kang","year":"2018","journal-title":"Biol Res Nurs"},{"key":"2024102404164312000_32.170.230134.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.10.283"},{"key":"2024102404164312000_32.170.230134.57","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201408-365OC"},{"key":"2024102404164312000_32.170.230134.58","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01699-2014"},{"key":"2024102404164312000_32.170.230134.59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228940"},{"key":"2024102404164312000_32.170.230134.60","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-038360"},{"key":"2024102404164312000_32.170.230134.61","first-page":"Suppl. 59, OA4973","article-title":"Gait speed as a predictor of mortality in COPD","volume":"46","author":"Kon","year":"2015","journal-title":"Eur Respir J"},{"key":"2024102404164312000_32.170.230134.62","first-page":"Suppl. 2, S206","article-title":"Grip weakness increases 30-day readmission for patients with acute exacerbation of COPD","volume":"33","author":"Spacht","year":"2018","journal-title":"J Gen Intern Med"},{"key":"2024102404164312000_32.170.230134.63","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.2147\/COPD.S143179","article-title":"Minimal important difference and responsiveness of 2-minute walk test performance in people with COPD undergoing pulmonary rehabilitation","volume":"12","author":"Johnston","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2024102404164312000_32.170.230134.64","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00162712"},{"key":"2024102404164312000_32.170.230134.65","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.112102"},{"key":"2024102404164312000_32.170.230134.66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/07853890.2014.969766","article-title":"Methodological considerations of the GRADE method","volume":"47","author":"Malmivaara","year":"2015","journal-title":"Ann Med"},{"key":"2024102404164312000_32.170.230134.67","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/ptj\/pzx063","article-title":"Measurement properties of short lower extremity functional exercise tests in people with chronic obstructive pulmonary disease: systematic review","volume":"97","author":"Johnston","year":"2017","journal-title":"Phys Ther"},{"key":"2024102404164312000_32.170.230134.68","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0109-2022"},{"key":"2024102404164312000_32.170.230134.69","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/S0140-6736(21)02630-1","article-title":"Benefits of physical activity interventions combining self-monitoring with other components versus self-monitoring alone: a systematic review and meta-analysis","volume":"398","author":"Vetrovsky","year":"2021","journal-title":"Lancet"},{"key":"2024102404164312000_32.170.230134.70","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217750088"},{"key":"2024102404164312000_32.170.230134.71","doi-asserted-by":"crossref","first-page":"e219","DOI":"10.1016\/S2468-2667(21)00302-9","article-title":"Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts","volume":"7","author":"Paluch","year":"2022","journal-title":"Lancet Public Health"},{"key":"2024102404164312000_32.170.230134.72","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00084514"},{"key":"2024102404164312000_32.170.230134.73","doi-asserted-by":"crossref","first-page":"18966","DOI":"10.1038\/s41598-021-98359-0","article-title":"Real-world gait speed estimation, frailty and handgrip strength: a cohort-based study","volume":"11","author":"Soltani","year":"2021","journal-title":"Sci Rep"},{"key":"2024102404164312000_32.170.230134.74","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0246-z"},{"key":"2024102404164312000_32.170.230134.75","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1923"},{"key":"2024102404164312000_32.170.230134.76","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.2.100"},{"key":"2024102404164312000_32.170.230134.77","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.060145"},{"key":"2024102404164312000_32.170.230134.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2005.04.016"},{"key":"2024102404164312000_32.170.230134.79","first-page":"34","article-title":"Differences in sedentary time, light physical activity, and steps associated with better COPD quality of life","volume":"9","author":"Driver","year":"2022","journal-title":"Chronic Obstr Pulm Dis"},{"key":"2024102404164312000_32.170.230134.80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154587"},{"key":"2024102404164312000_32.170.230134.81","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/ebmental-2019-300129","article-title":"Challenges in meta-analyses with observational studies","volume":"23","author":"Metelli","year":"2020","journal-title":"Evid Based Ment Health"},{"key":"2024102404164312000_32.170.230134.82","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00088113"},{"key":"2024102404164312000_32.170.230134.83","first-page":"528","article-title":"Objectively measured physical activity in patients with COPD: recommendations from an international task force on physical activity","volume":"8","author":"Demeyer","year":"2021","journal-title":"Chronic Obstr Pulm Dis"}],"container-title":["European Respiratory Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/16000617.0134-2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:06:29Z","timestamp":1740373589000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/16000617.0134-2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":83,"journal-issue":{"issue":"170","published-online":{"date-parts":[[2023,11,22]]},"published-print":{"date-parts":[[2023,12,31]]}},"alternative-id":["10.1183\/16000617.0134-2023"],"URL":"https:\/\/doi.org\/10.1183\/16000617.0134-2023","relation":{},"ISSN":["0905-9180","1600-0617"],"issn-type":[{"value":"0905-9180","type":"print"},{"value":"1600-0617","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,22]]}}}