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The<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub><jats:italic>versus V<\/jats:italic>\u2032<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>relationship has a relevant prognostic power either alone or, better, when included within prognostic scores. The<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub><jats:italic>versus V<\/jats:italic>\u2032<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>slope is reported as an absolute number with a recognised cut-off prognostic value of 35, except for specific diseases such as hypertrophic cardiomyopathy and idiopathic cardiomyopathy, where a lower cut-off has been suggested. However, nowadays, it is more appropriate to report<jats:italic>V<\/jats:italic>\u2032<jats:sub>E<\/jats:sub><jats:italic>versus V<\/jats:italic>\u2032<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>slope as percentage of the predicted value, due to age and gender interferences. 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