{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:38:34Z","timestamp":1791841114819,"version":"4.3.4"},"reference-count":193,"publisher":"European Respiratory Society (ERS)","issue":"173","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir Rev"],"accepted":{"date-parts":[[2024,3,9]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Bronchiectasis is a heterogeneous disease with multiple aetiologies and diverse clinical features. There is a general consensus that optimal treatment requires precision medicine approaches focused on specific treatable disease characteristics, known as treatable traits. Identifying subtypes of conditions with distinct underlying biology (endotypes) depends on the identification of biomarkers that are associated with disease features, prognosis or treatment response and which can be applied in clinical practice. Bronchiectasis is a disease characterised by inflammation, infection, structural lung damage and impaired mucociliary clearance. Increasingly there are available methods to measure each of these components of the disease, revealing heterogeneous inflammatory profiles, microbiota, radiology and mucus and epithelial biology in patients with bronchiectasis. Using emerging biomarkers and omics technologies to guide treatment in bronchiectasis is a promising field of research. Here we review the most recent data on biomarkers in bronchiectasis.<\/jats:p>","DOI":"10.1183\/16000617.0234-2023","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T09:20:50Z","timestamp":1719998450000},"page":"230234","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Biomarkers in bronchiectasis"],"prefix":"10.1183","volume":"33","author":[{"given":"Emma","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete B.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"2024102404212493000_33.173.230234.1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-212463"},{"key":"2024102404212493000_33.173.230234.2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00629-2017"},{"key":"2024102404212493000_33.173.230234.3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5694\/mja14.00287","article-title":"Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand Thoracic Society of Australia and New Zealand guidelines","volume":"202","author":"Chang","year":"2015","journal-title":"Med J Aust"},{"key":"2024102404212493000_33.173.230234.4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.rmed.2019.09.012","article-title":"Epidemiology of bronchiectasis in the UK: findings from the British Lung Foundation's \u2018Respiratory Health of the Nation\u2019 project","volume":"158","author":"Snell","year":"2019","journal-title":"Respir Med"},{"key":"2024102404212493000_33.173.230234.5","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0140-6736(18)31767-7","article-title":"Advances in bronchiectasis: endotyping, genetics, microbiome and disease heterogeneity","volume":"392","author":"Flume","year":"2018","journal-title":"Lancet"},{"key":"2024102404212493000_33.173.230234.6","first-page":"6","article-title":"Inflammation: a two-edged sword \u2013 the model of bronchiectasis","volume":"147","author":"Cole","year":"1986","journal-title":"Eur J Respir Dis Suppl"},{"key":"2024102404212493000_33.173.230234.7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00003709"},{"key":"2024102404212493000_33.173.230234.8","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205918"},{"key":"2024102404212493000_33.173.230234.9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12890-019-0818-6","article-title":"The economic burden of bronchiectasis \u2013 known and unknown: a systematic review","volume":"19","author":"Goeminne","year":"2019","journal-title":"BMC Pulm Med"},{"key":"2024102404212493000_33.173.230234.10","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0638-0"},{"key":"2024102404212493000_33.173.230234.11","doi-asserted-by":"crossref","unstructured":"McDonnell MJ , Ward C , Rutherford RM . Comorbidities and their impact. In: Chalmers JD , Polverino E , Aliberti S , eds. Bronchiectasis (ERS Monograph). Sheffield, European Respiratory Society, 2018; pp. 45\u201361.","DOI":"10.1183\/2312508X.10015417"},{"key":"2024102404212493000_33.173.230234.12","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S2213-2600(23)00093-0","article-title":"Bronchiectasis in Europe: data on disease characteristics from the European Bronchiectasis registry (EMBARC)","volume":"11","author":"Chalmers","year":"2023","journal-title":"Lancet Respir Med"},{"key":"2024102404212493000_33.173.230234.13","doi-asserted-by":"crossref","unstructured":"Chalmers JD . Phenotypes and endotypes. In: Chalmers JD , Polverino E , Aliberti S , et al. , eds. Bronchiectasis (ERS Monograph). 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