{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:11:32Z","timestamp":1792429892169,"version":"4.5.0"},"reference-count":91,"publisher":"European Respiratory Society (ERS)","issue":"180","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir Rev"],"accepted":{"date-parts":[[2026,1,4]]},"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    Breathing disturbances during sleep are associated with intermittent hypoxaemia, arousal and sympathetic activation, which in turn lead to oxidative stress and cardiovascular and metabolic consequences. However, they are also characterised by fluctuations of carbon dioxide levels, switching between hypercapnia and hypocapnia, which contribute to acute and sustained physiological and cellular effects. Changes in arterial carbon dioxide tension (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>\n                      aCO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    ) influence cerebral blood flow, respiratory control and renal function. The complex pathophysiology requires the integration of clinical entities and therapeutical options based on precise measurement of CO\n                    <jats:sub>2<\/jats:sub>\n                    . Continuous measurements during the night best reflect nocturnal changes in CO\n                    <jats:sub>2<\/jats:sub>\n                    levels. Alveolar, arterial, capillary and transcutaneous CO\n                    <jats:sub>2<\/jats:sub>\n                    measurements represent distinct characterisations of CO\n                    <jats:sub>2<\/jats:sub>\n                    fluctuations. Alveolar and arterial CO\n                    <jats:sub>2<\/jats:sub>\n                    levels are very similar and correlate closely to the end-tidal CO\n                    <jats:sub>2<\/jats:sub>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>\n                      ETCO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    ) in healthy subjects. However, the validity of\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>ET<\/jats:sub>\n                    <jats:sub>\n                      CO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    is limited in diseases with inhomogeneous lung ventilation and, due to artefacts, during mechanical ventilation. Transcutaneous CO\n                    <jats:sub>2<\/jats:sub>\n                    measurement has proven to adequately represent\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>\n                      aCO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    , although time delays in response and absolute figures can differ. Obesity hypoventilation syndrome (OHS) exemplifies a frequent clinical condition with multiple pathophysiological components impacting\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>\n                      CO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    levels differently across 24\u2005h. Treatment is often delayed due to limited awareness of mild hypercapnia occurring exclusively during night-time. Positive airway pressure (PAP) therapy remains the cornerstone of management. The choice between continuous positive airway pressure or noninvasive ventilation should be guided by the predominant OHS phenotype and the severity of daytime hypercapnia. Management of OHS should also focus on cardiometabolic comorbidities and include a multimodal approach to the underlying obesity.\n                  <\/jats:p>","DOI":"10.1183\/16000617.0260-2025","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:30:38Z","timestamp":1778661038000},"page":"250260","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Nocturnal hypercapnia in obstructive sleep apnoea and obesity hypoventilation: from pathophysiology to measurement and treatment"],"prefix":"10.1183","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5010-8461","authenticated-orcid":false,"given":"Winfried J.","family":"Randerath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fanfulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Louis","family":"P\u00e9pin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"2026062507401536000_35.180.250260.1","doi-asserted-by":"crossref","first-page":"20200033","DOI":"10.1098\/rsfs.2020.0033","article-title":"Carbon dioxide-dependent signal transduction in mammalian systems","volume":"11","author":"Phelan","year":"2021","journal-title":"Interface Focus"},{"key":"2026062507401536000_35.180.250260.2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90184-3"},{"key":"2026062507401536000_35.180.250260.3","first-page":"758","article-title":"Hypercapnic ventilatory response in sleeping adults","volume":"126","author":"Douglas","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"2026062507401536000_35.180.250260.4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0034-5687(67)90012-6","article-title":"Effect of sleep on ventilatory response to CO2 in severe hypoxia","volume":"3","author":"Honda","year":"1967","journal-title":"Respir Physiol"},{"key":"2026062507401536000_35.180.250260.5","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-4584-1_16"},{"key":"2026062507401536000_35.180.250260.6","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00497.2020"},{"key":"2026062507401536000_35.180.250260.7","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-91534-2.00007-2"},{"key":"2026062507401536000_35.180.250260.8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014397"},{"key":"2026062507401536000_35.180.250260.9","doi-asserted-by":"crossref","first-page":"102922","DOI":"10.1016\/j.autneu.2021.102922","article-title":"Rostral ventrolateral medulla, retropontine region and autonomic regulations","volume":"237","author":"Guyenet","year":"2022","journal-title":"Auton Neurosci"},{"key":"2026062507401536000_35.180.250260.10","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1113\/JP285487","article-title":"Revisiting the assumption of a rebreathing-induced arterial-brain CO2 equilibrium half a century later","volume":"601","author":"Dempsey","year":"2023","journal-title":"J Physiol"},{"key":"2026062507401536000_35.180.250260.11","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01059.2009"},{"key":"2026062507401536000_35.180.250260.12","doi-asserted-by":"publisher","DOI":"10.1113\/JP271480"},{"key":"2026062507401536000_35.180.250260.13","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.103788"},{"key":"2026062507401536000_35.180.250260.14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040239"},{"key":"2026062507401536000_35.180.250260.15","doi-asserted-by":"publisher","DOI":"10.1113\/EP089446"},{"key":"2026062507401536000_35.180.250260.16","doi-asserted-by":"crossref","first-page":"e25232","DOI":"10.7554\/eLife.25232","article-title":"Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe","volume":"6","author":"Hawkins","year":"2017","journal-title":"eLife"},{"key":"2026062507401536000_35.180.250260.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2004.04.006"},{"key":"2026062507401536000_35.180.250260.18","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.8.838"},{"key":"2026062507401536000_35.180.250260.19","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.11.989"},{"key":"2026062507401536000_35.180.250260.20","first-page":"215","article-title":"Autonomic dysfunction in patients with chronic obstructive pulmonary disease (COPD)","volume":"2","author":"van Gestel","year":"2010","journal-title":"J Thorac Dis"},{"key":"2026062507401536000_35.180.250260.21","doi-asserted-by":"crossref","first-page":"919422","DOI":"10.3389\/fphys.2022.919422","article-title":"Sympathetic and vagal nerve activity in COPD: pathophysiology, presumed determinants and underappreciated therapeutic potential","volume":"13","author":"Spiesshoefer","year":"2022","journal-title":"Front Physiol"},{"key":"2026062507401536000_35.180.250260.22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00035.2020"},{"key":"2026062507401536000_35.180.250260.23","first-page":"737","article-title":"Hyperoxia blunts renal sympathetic nerve activity response to acute intermittent hypercapnia in rats","volume":"70","author":"Madirazza","year":"2019","journal-title":"J Physiol Pharmacol"},{"key":"2026062507401536000_35.180.250260.24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200203-212OC"},{"key":"2026062507401536000_35.180.250260.25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1152\/jappl.2000.88.1.257","article-title":"CO2 homeostasis during periodic breathing in obstructive sleep apnea","volume":"88","author":"Berger","year":"2000","journal-title":"J Appl Physiol (1985)"},{"key":"2026062507401536000_35.180.250260.26","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01082.2001"},{"key":"2026062507401536000_35.180.250260.27","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00502.2005"},{"key":"2026062507401536000_35.180.250260.28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM196607212750301","article-title":"The \u201ccarbon dioxide response curve\u201d for chronic hypercapnia in man","volume":"275","author":"Van Yperselle de","year":"1966","journal-title":"N Engl J Med"},{"key":"2026062507401536000_35.180.250260.29","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204298"},{"key":"2026062507401536000_35.180.250260.30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.sleep.2022.11.041","article-title":"Arterial bicarbonate is associated with hypoxic burden and uncontrolled hypertension in obstructive sleep apnea \u2013 the ESADA cohort","volume":"102","author":"Zou","year":"2023","journal-title":"Sleep Med"},{"key":"2026062507401536000_35.180.250260.31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1177\/194336549203700305","article-title":"Transcutaneous P\n               CO2\n                and end-tidal P\n               CO2\n                in ventilated adults","volume":"37","author":"Blanchette","year":"1992","journal-title":"Respir Care"},{"key":"2026062507401536000_35.180.250260.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2006.02.007"},{"key":"2026062507401536000_35.180.250260.33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1460-9592.2003.01176.x","article-title":"Transcutaneous carbon dioxide monitoring during diabetic ketoacidosis in children and adolescents","volume":"14","author":"McBride","year":"2004","journal-title":"Paediatr Anaesth"},{"key":"2026062507401536000_35.180.250260.34","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00088005"},{"key":"2026062507401536000_35.180.250260.35","doi-asserted-by":"publisher","DOI":"10.1159\/000083990"},{"key":"2026062507401536000_35.180.250260.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.05.011"},{"key":"2026062507401536000_35.180.250260.37","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1097\/00003246-199805000-00020","article-title":"Apnea testing guided by continuous transcutaneous monitoring of partial pressure of carbon dioxide","volume":"26","author":"Lang","year":"1998","journal-title":"Crit Care Med"},{"key":"2026062507401536000_35.180.250260.38","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1291"},{"key":"2026062507401536000_35.180.250260.39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3109\/03009738909178562","article-title":"Transcutaneous CO2 monitoring in adults with sleep-related breathing disorders","volume":"94","author":"Gislason","year":"1989","journal-title":"Ups J Med Sci"},{"key":"2026062507401536000_35.180.250260.40","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.051664"},{"key":"2026062507401536000_35.180.250260.41","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13e18.x"},{"key":"2026062507401536000_35.180.250260.42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11818-999-0001-z","article-title":"Multicenter-studie \u201cKapnographie in der Schlafmedizin\u201d [Capnography in sleep medicine, a multicenter study]","volume":"3","author":"Sch\u00e4fer","year":"1999","journal-title":"Somnologie"},{"key":"2026062507401536000_35.180.250260.43","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1515\/bmte.2003.48.6.170","article-title":"Method for measuring respiration in sleep: capnography for determining ventilation","volume":"48","author":"Sch\u00e4fer","year":"2003","journal-title":"Biomed Tech (Berl)"},{"key":"2026062507401536000_35.180.250260.44","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s11818-997-0032-2","article-title":"Zur bedeutung des CO2\u2013partialdruckes als messgr\u00f6\u00dfe im schlaflabor [CO2-Partial pressure as measure in sleep medicine]","volume":"1","author":"Schl\u00e4fke","year":"1997","journal-title":"Somnologie"},{"key":"2026062507401536000_35.180.250260.45","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04919"},{"key":"2026062507401536000_35.180.250260.46","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00507-2022"},{"key":"2026062507401536000_35.180.250260.47","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5812\/atr.6444","article-title":"Correlation of end-tidal carbon dioxide with arterial carbon dioxide in mechanically ventilated patients","volume":"1","author":"Razi","year":"2012","journal-title":"Arch Trauma Res"},{"key":"2026062507401536000_35.180.250260.48","first-page":"1027","article-title":"A combined transcutaneous P\n               O2\n               \u2013P\n               CO2\n                electrode with electrochemical HCO3- stabilization","volume":"51","author":"Severinghaus","year":"1981","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"2026062507401536000_35.180.250260.49","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1399-6576.1978.tb01405.x","article-title":"tcP\n               CO2\n                electrode design, calibration and temperature gradient problems","volume":"68","author":"Severinghaus","year":"1978","journal-title":"Acta Anaesthesiol Scand Suppl"},{"key":"2026062507401536000_35.180.250260.50","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/194336548202700206","article-title":"Transcutaneous blood gas analysis. The 1981 Donald F Egan lecture","volume":"27","author":"Severinghaus","year":"1982","journal-title":"Respir Care"},{"key":"2026062507401536000_35.180.250260.51","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1007\/s11325-022-02568-4","article-title":"Sleep-related hypoventilation and hypercapnia in multiple system atrophy detected by polysomnography with transcutaneous carbon dioxide monitoring","volume":"26","author":"Sugiyama","year":"2022","journal-title":"Sleep Breath"},{"key":"2026062507401536000_35.180.250260.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.01.017"},{"key":"2026062507401536000_35.180.250260.53","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.6_Pt_1.1599"},{"key":"2026062507401536000_35.180.250260.54","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1002\/ppul.24966","article-title":"TcCO2 changes correlate with partial obstruction in children suspected of sleep disordered breathing","volume":"55","author":"D'Souza","year":"2020","journal-title":"Pediatr Pulmonol"},{"key":"2026062507401536000_35.180.250260.55","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04212"},{"key":"2026062507401536000_35.180.250260.56","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000187631","article-title":"Accuracy of transcutaneous carbon dioxide tension measurements during cardiopulmonary exercise testing","volume":"78","author":"Stege","year":"2009","journal-title":"Respiration"},{"key":"2026062507401536000_35.180.250260.57","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1744"},{"key":"2026062507401536000_35.180.250260.58","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0946"},{"key":"2026062507401536000_35.180.250260.59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.02930.x"},{"key":"2026062507401536000_35.180.250260.60","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3233\/JND-200516","article-title":"Transcutaneous carbon dioxide measurement in adult patients with neuromuscular disorders: a quality level assessment","volume":"8","author":"De Braekeleer","year":"2021","journal-title":"J Neuromuscul Dis"},{"key":"2026062507401536000_35.180.250260.61","first-page":"S76","article-title":"Combining transcutaneous blood gas measurement and pulse oximetry","volume":"94","author":"Eberhard","year":"2002","journal-title":"Anesth Analg"},{"key":"2026062507401536000_35.180.250260.62","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4005(01)00612-8"},{"key":"2026062507401536000_35.180.250260.63","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2001.1045"},{"key":"2026062507401536000_35.180.250260.64","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06094"},{"key":"2026062507401536000_35.180.250260.65","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11325-025-03455-4","article-title":"Non-invasive P\n               CO2\n                monitoring during polysomnography: transcutaneous versus end-tidal measurement","volume":"29","author":"Park","year":"2025","journal-title":"Sleep Breath"},{"key":"2026062507401536000_35.180.250260.66","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.04.64"},{"key":"2026062507401536000_35.180.250260.67","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00959-2016"},{"key":"2026062507401536000_35.180.250260.68","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S2213-2600(16)00054-0","article-title":"Prevention and care of respiratory failure in obese patients","volume":"4","author":"P\u00e9pin","year":"2016","journal-title":"Lancet Respir Med"},{"key":"2026062507401536000_35.180.250260.69","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201905-1071ST"},{"key":"2026062507401536000_35.180.250260.70","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0097-2018"},{"key":"2026062507401536000_35.180.250260.71","doi-asserted-by":"crossref","first-page":"106491","DOI":"10.1016\/j.sleep.2025.106491","article-title":"Obesity hypoventilation syndrome: current status and future directions for optimizing care of a complex and diverse condition (a narrative review)","volume":"131","author":"P\u00e9pin","year":"2025","journal-title":"Sleep Med"},{"key":"2026062507401536000_35.180.250260.72","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1513\/AnnalsATS.202411-1160OC","article-title":"Health trajectories around noninvasive ventilation initiation for obesity hypoventilation syndrome","volume":"22","author":"P\u00e9pin","year":"2025","journal-title":"Ann Am Thorac Soc"},{"key":"2026062507401536000_35.180.250260.73","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2021-218497"},{"key":"2026062507401536000_35.180.250260.74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052006"},{"key":"2026062507401536000_35.180.250260.75","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-208501"},{"key":"2026062507401536000_35.180.250260.76","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201410-1900OC"},{"key":"2026062507401536000_35.180.250260.77","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.chest.2020.03.068","article-title":"Long-term noninvasive ventilation in obesity hypoventilation syndrome without severe OSA: the Pickwick randomized controlled trial","volume":"158","author":"Masa","year":"2020","journal-title":"Chest"},{"key":"2026062507401536000_35.180.250260.78","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32978-7"},{"key":"2026062507401536000_35.180.250260.79","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/resp.13746","article-title":"Step-down from non-invasive ventilation to continuous positive airway pressure: a better phenotyping is required","volume":"25","author":"Patout","year":"2020","journal-title":"Respirology"},{"key":"2026062507401536000_35.180.250260.80","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/resp.13704","article-title":"Obesity hypoventilation syndrome treated with non-invasive ventilation: is a switch to CPAP therapy feasible?","volume":"25","author":"Arellano-Maric","year":"2020","journal-title":"Respirology"},{"key":"2026062507401536000_35.180.250260.81","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12890-017-0391-9","article-title":"Switch of noninvasive ventilation (NIV) to continuous positive airway pressure (CPAP) in patients with obesity hypoventilation syndrome: a pilot study","volume":"17","author":"Orfanos","year":"2017","journal-title":"BMC Pulm Med"},{"key":"2026062507401536000_35.180.250260.82","first-page":"101114","article-title":"Real-life evaluation of NIV to CPAP switch in patients with chronic respiratory failure. A case control study","volume":"86","author":"Mathieu","year":"2024","journal-title":"Respir Med Res"},{"key":"2026062507401536000_35.180.250260.83","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1513\/AnnalsATS.201912-887OC","article-title":"The effect of hospital discharge with empiric noninvasive ventilation on mortality in hospitalized patients with obesity hypoventilation syndrome. An individual patient data meta-analysis","volume":"17","author":"Mokhlesi","year":"2020","journal-title":"Ann Am Thorac Soc"},{"key":"2026062507401536000_35.180.250260.84","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215613"},{"key":"2026062507401536000_35.180.250260.85","doi-asserted-by":"crossref","first-page":"983","DOI":"10.5664\/jcsm.9760","article-title":"Risk factors associated with pulmonary hypertension in obesity hypoventilation syndrome","volume":"18","author":"Masa","year":"2022","journal-title":"J Clin Sleep Med"},{"key":"2026062507401536000_35.180.250260.86","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0090-2025"},{"key":"2026062507401536000_35.180.250260.87","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2404881"},{"key":"2026062507401536000_35.180.250260.88","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.chest.2025.09.019","article-title":"Acetazolamide plus atomoxetine for obesity hypoventilation syndrome treatment","volume":"169","author":"Perger","year":"2026","journal-title":"Chest"},{"key":"2026062507401536000_35.180.250260.89","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-209826"},{"key":"2026062507401536000_35.180.250260.90","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-211152"},{"key":"2026062507401536000_35.180.250260.91","doi-asserted-by":"publisher","DOI":"10.1186\/cc696"}],"container-title":["European Respiratory Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/16000617.0260-2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:40:56Z","timestamp":1782398456000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/16000617.0260-2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":91,"journal-issue":{"issue":"180","published-online":{"date-parts":[[2026,5,13]]},"published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1183\/16000617.0260-2025"],"URL":"https:\/\/doi.org\/10.1183\/16000617.0260-2025","relation":{},"ISSN":["0905-9180","1600-0617"],"issn-type":[{"value":"0905-9180","type":"print"},{"value":"1600-0617","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}