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In the lungs of people living with cystic fibrosis (pwCF), where\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    is a major contributor to the disease process, bacteria reside within a complex physicochemical environment that drives their behaviour. Until recently, efforts to evaluate how well laboratory models mimic these\n                    <jats:italic>in vivo<\/jats:italic>\n                    conditions were hampered by limited data on the physiology of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    during chronic cystic fibrosis (CF) lung infections. However, several omics-based studies have now successfully characterised\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    from human CF sputum, revealing unique adaptation patterns associated within this niche. This data enables evaluating the physiological relevance of\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    model systems, hereby highlighting the usefulness (and limitations) of models that mimic aspects of the physicochemical\n                    <jats:italic>in vivo<\/jats:italic>\n                    environment for studying\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    infections in CF. In this review, we summarise a range of models of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    infection, including artificial sputum medium, air\u2013liquid interface cell culture,\n                    <jats:italic>ex vivo<\/jats:italic>\n                    pig lung and mouse models, that have been evaluated for their physiological resemblance using omics-based approaches. We also address the current lack of proteomic and metabolomic validation approaches and outline key considerations and future directions to guide the continued refinement of experimental model systems.\n                  <\/jats:p>","DOI":"10.1183\/16000617.0282-2025","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:20:15Z","timestamp":1791364815000},"page":"250282","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging bench and bedside: translational omics of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    to validate physiologically relevant models of chronic respiratory infection in cystic fibrosis"],"prefix":"10.1183","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-9759","authenticated-orcid":false,"given":"Merel","family":"Wauters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-1943","authenticated-orcid":false,"given":"Laura","family":"Boll\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7242-0747","authenticated-orcid":false,"given":"Eva","family":"Van Braeckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3084-4418","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Crabb\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"2026100702200602000_35.182.250282.1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-024-01316-5"},{"key":"2026100702200602000_35.182.250282.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1421OC"},{"key":"2026100702200602000_35.182.250282.3","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1093\/cid\/ciaf009","article-title":"State-of-the-art review: transformative changes in the care of people with cystic fibrosis: implications for infectious diseases specialists","volume":"80","author":"Saiman","year":"2025","journal-title":"Clin Infect Dis"},{"key":"2026100702200602000_35.182.250282.4","unstructured":"Zolin A , Adamoli A , Bakkeheim E , et al. 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