{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:26:28Z","timestamp":1790666788757,"version":"4.1.0"},"reference-count":48,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ersjournals.com"],"crossmark-restriction":true},"short-container-title":["Breathe"],"accepted":{"date-parts":[[2021,8,24]]},"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>With increasing prevalence of obesity, the substantial contribution of obesity hypoventilation syndrome (OHS) to morbidity and mortality is likely to increase. It is therefore crucial that the condition has a clear definition to allow timely identification of patients. OHS was first described as \u201cPickwickian syndrome\u201d in the 1950s; in subsequent decades, case reports did not clearly delineate between patients suffering from OHS and those suffering from obstructive sleep apnoea. In 1999, the American Academy of Sleep Medicine published a guideline that delineated the cause of daytime hypercapnia as either predominantly upper airway or predominantly hypoventilation. This was the first formal definition of OHS as the presence of daytime alveolar hypoventilation (arterial carbon dioxide tension &gt;45\u2005mmHg) in patients with body mass index &gt;30\u2005kg\u00b7m<jats:sup>\u22122<\/jats:sup>in the absence of other causes of hypoventilation. This definition is reflected in the most recent guidelines published on OHS. Recent developments in defining OHS include proposed classification systems of severity and demonstrating the value of using serum bicarbonate to exclude OHS in patients with a low index of suspicion.<\/jats:p><jats:sec><jats:title>Educational aims<\/jats:title><jats:list list-type=\"bullet\"><jats:list-item><jats:p>To provide an overview of the historical basis of the definition of obesity hypoventilation syndrome.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>To explain the rationale for the current definition of obesity hypoventilation syndrome.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>To demonstrate areas that need further investigation in defining obesity hypoventilation syndrome.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:sec>","DOI":"10.1183\/20734735.0089-2021","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T08:22:42Z","timestamp":1633422162000},"page":"210089","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Defining obesity hypoventilation syndrome"],"prefix":"10.1183","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7679-0825","authenticated-orcid":false,"given":"Neeraj M.","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Shrimanker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Kaltsakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"2024101703585665000_17.3.210089.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.09.005"},{"key":"2024101703585665000_17.3.210089.2","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-015-0169-4"},{"key":"2024101703585665000_17.3.210089.3","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-006-0092-8"},{"key":"2024101703585665000_17.3.210089.4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117808"},{"key":"2024101703585665000_17.3.210089.5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/osp4.27","article-title":"The clinical characteristics and hospital and post-hospital survival of patients with the obesity hypoventilation syndrome: analysis of a large cohort","volume":"2","author":"Marik","year":"2016","journal-title":"Obes Sci Pract"},{"key":"2024101703585665000_17.3.210089.6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2472"},{"key":"2024101703585665000_17.3.210089.7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/1874306401711010031","article-title":"Survival of hypercapnic patients with COPD and obesity hypoventilation syndrome treated with high intensity non invasive ventilation in the daily routine care","volume":"11","author":"Blankenburg","year":"2017","journal-title":"Open Respir Med J"},{"key":"2024101703585665000_17.3.210089.8","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1111\/crj.12754","article-title":"Prevalence of comorbidities in patients with obstructive sleep apnea syndrome, overlap syndrome and obesity hypoventilation syndrome","volume":"12","author":"Lacedonia","year":"2018","journal-title":"Clin Respir J"},{"key":"2024101703585665000_17.3.210089.9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052006"},{"key":"2024101703585665000_17.3.210089.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.2.377"},{"key":"2024101703585665000_17.3.210089.11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.arbres.2014.02.015","article-title":"Noninvasive mechanical ventilation in patients with obesity hypoventilation syndrome. 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