{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:59:42Z","timestamp":1790283582284,"version":"4.1.0"},"reference-count":88,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ersjournals.com"],"crossmark-restriction":true},"short-container-title":["Breathe"],"accepted":{"date-parts":[[2022,8,12]]},"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Treatment of obstructive sleep apnoea in adults is evolving, from a \u201cone treatment fits all\u201d to a more individualised approach. The spectrum of treatment options is broad and heterogeneous, including conservative, technological and pharmaceutical modalities. This raises the questions of which patients these modalities might be useful for, and if there are specific criteria for single or combined treatment. The most commonly used non-CPAP treatment is a mandibular advancement device. Furthermore, it appears from the available evidence that upper airway surgery, bariatric surgery, and maxillomandibular advancement can be effective in particular patient groups and should be indicated more readily in clinical practice. Technically, a tracheotomy is the most effective surgical treatment, but is not socially acceptable and is associated with major side-effects. Other treatment options are emerging, like positional therapy, hypoglossal nerve stimulation, and myofunctional exercises. Drug therapy is also promising when pathophysiological traits are considered.<\/jats:p><jats:p>The range of currently available treatment options will be discussed in this review, with emphasis on the selection of appropriate patients, therapeutic efficacy and compliance, and reference to recent guidelines. In the selection process, routine application of drug-induced sleep endoscopy to assess the site(s) of collapse during sleep can increase the success rate of both surgical interventions and oral appliance therapy.<\/jats:p><jats:sec><jats:title>Educational aims<\/jats:title><jats:list list-type=\"bullet\"><jats:list-item><jats:p>To outline recommendations concerning the proper management of obstructive sleep apnoea (OSA) patients that cannot be treated adequately with continuous positive airway pressure (CPAP) due to intolerance, poor adherence or compliance, or CPAP refusal.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>To provide information about the selection of appropriate patients for alternative non-CPAP treatment options.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>To better understand the different aspects of OSA treatment with noninvasive approaches, such as oral appliances, positional therapy, drug treatment and myofunctional therapy, including indications, contraindications, and expected short- and long-term results.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>To discuss the different surgical options for the treatment of OSA and to provide information on the important issue of proper patient selection for surgery, as most OSA surgical outcomes are associated with the pre-operative assessment of the level(s) of upper airway collapse.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:sec>","DOI":"10.1183\/20734735.0164-2022","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T09:05:43Z","timestamp":1665479143000},"page":"220164","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":70,"title":["Non-CPAP therapy for obstructive sleep apnoea"],"prefix":"10.1183","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6087-678X","authenticated-orcid":false,"given":"Johan","family":"Verbraecken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5822-1960","authenticated-orcid":false,"given":"Marijke","family":"Dieltjens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5978-9814","authenticated-orcid":false,"given":"Sara","family":"Op de Beeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-2021","authenticated-orcid":false,"given":"Anneclaire","family":"Vroegop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-4240","authenticated-orcid":false,"given":"Marc","family":"Braem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4088-4213","authenticated-orcid":false,"given":"Olivier","family":"Vanderveken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5010-8461","authenticated-orcid":false,"given":"Winfried","family":"Randerath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"2024101704045152000_18.3.220164.1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00099710"},{"key":"2024101704045152000_18.3.220164.2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0200-2021"},{"key":"2024101704045152000_18.3.220164.3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00.16592100"},{"key":"2024101704045152000_18.3.220164.4","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-201900"},{"key":"2024101704045152000_18.3.220164.5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.45.4.353"},{"key":"2024101704045152000_18.3.220164.6","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s11845-021-02671-7","article-title":"Alcohol as an independent risk factor for obstructive sleep apnea","volume":"191","author":"Yang","year":"2022","journal-title":"Ir J Med Sci"},{"key":"2024101704045152000_18.3.220164.7","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1113\/JP280173","article-title":"Zolpidem increases sleep efficiency and the respiratory arousal threshold without changing sleep apnoea severity and pharyngeal muscle activity","volume":"598","author":"Messineo","year":"2020","journal-title":"J Physiol"},{"key":"2024101704045152000_18.3.220164.8","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1164\/rccm.201807-1326ST","article-title":"The role of weight management in the treatment of adult obstructive sleep apnea. 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