{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:26:23Z","timestamp":1772627183905,"version":"3.50.1"},"reference-count":33,"publisher":"European Respiratory Society (ERS)","issue":"3","funder":[{"name":"National Health and Medical Research Council of Australia","award":["APP1020555"],"award-info":[{"award-number":["APP1020555"]}]},{"name":"National Health and Medical Research Council of Australia","award":["APP1088389"],"award-info":[{"award-number":["APP1088389"]}]},{"name":"National Health and Medical Research Council of Australia","award":["APP513730"],"award-info":[{"award-number":["APP513730"]}]},{"name":"National Health and Medical Research Council of Australia","award":["CRE1000896"],"award-info":[{"award-number":["CRE1000896"]}]},{"DOI":"10.13039\/100006501","name":"Cystic Fibrosis Foundation Therapeutics","doi-asserted-by":"publisher","award":["SLY04A0"],"award-info":[{"award-number":["SLY04A0"]}],"id":[{"id":"10.13039\/100006501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006501","name":"Cystic Fibrosis Foundation Therapeutics","doi-asserted-by":"publisher","award":["STICK09A0"],"award-info":[{"award-number":["STICK09A0"]}],"id":[{"id":"10.13039\/100006501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2016,7,26]]},"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Respiratory infections are a major cause of pulmonary decline in children with cystic fibrosis (CF). We compared the prevalence of infection in early life at geographically distant CF treatment centres participating in the same surveillance programme in Australia.<\/jats:p><jats:p>Lower airway microbiology, inflammation and structural lung disease at annual review were evaluated for 260 children 0\u20138\u2005years old with CF at 1032 visits to CF treatment centres in Melbourne or Perth.<\/jats:p><jats:p>Melbourne patients were more likely to be culture-positive for common respiratory pathogens at all age groups (odds ratio (OR) 1.85, 95% CI 1.33\u20132.58). Subjects &lt;2\u2005years old in Melbourne were also more likely to have neutrophil elastase present (OR 3.11, 95% CI 1.62\u20135.95). Bronchiectasis (OR 2.02, 95% CI 1.21\u20133.38) and air trapping (OR 2.53, 95% CI 1.42\u20134.51) in subjects 2\u20135\u2005years old was more common in Melbourne subjects. The severity of structural lung disease was also worse in Melbourne patients &gt;5\u2005years old. Patients at both centres had a similar rate of hospitalisations and prescribed antibiotics.<\/jats:p><jats:p>No procedural differences were identified that could explain the disparity between pathogen prevalence. Geographical differences in early acquisition of infection may contribute to variability in outcomes between CF centres.<\/jats:p>","DOI":"10.1183\/23120541.00014-2016","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T10:31:38Z","timestamp":1474885898000},"page":"00014-2016","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts"],"prefix":"10.1183","volume":"2","author":[{"given":"Kathryn A.","family":"Ramsey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidija","family":"Turkovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Padros-Goossens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Stick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarath C.","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"2024101706482023000_2.3.00014-2016.1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.068262"},{"key":"2024101706482023000_2.3.00014-2016.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201011-1892OC"},{"key":"2024101706482023000_2.3.00014-2016.3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138412"},{"key":"2024101706482023000_2.3.00014-2016.4","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1144"},{"key":"2024101706482023000_2.3.00014-2016.5","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20294"},{"key":"2024101706482023000_2.3.00014-2016.6","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950200203"},{"key":"2024101706482023000_2.3.00014-2016.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200901-0069OC"},{"key":"2024101706482023000_2.3.00014-2016.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.05.005"},{"key":"2024101706482023000_2.3.00014-2016.9","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200912"},{"key":"2024101706482023000_2.3.00014-2016.10","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.139493"},{"key":"2024101706482023000_2.3.00014-2016.11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00178508"},{"key":"2024101706482023000_2.3.00014-2016.12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir399"},{"key":"2024101706482023000_2.3.00014-2016.13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201407-1277OC"},{"key":"2024101706482023000_2.3.00014-2016.14","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00068-09"},{"key":"2024101706482023000_2.3.00014-2016.15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1513\/AnnalsATS.201209-077OC","article-title":"Geographical differences in first acquisition of Pseudomonas aeruginosa in cystic fibrosis","volume":"10","author":"Ranganathan","year":"2013","journal-title":"Ann Am Thorac Soc"},{"key":"2024101706482023000_2.3.00014-2016.16","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.026419"},{"key":"2024101706482023000_2.3.00014-2016.17","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00036-10"},{"key":"2024101706482023000_2.3.00014-2016.18","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01650-10"},{"key":"2024101706482023000_2.3.00014-2016.19","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.45557-0"},{"key":"2024101706482023000_2.3.00014-2016.20","unstructured":"Cystic Fibrosis Australia. Cystic Fibrosis in Australia 2007\u22122011. Annual Reports from the Australian Cystic Fibrosis Data Registry. www.cysticfibrosis.org.au\/cfa\/data-registry Date last accessed: December 14, 2012."},{"key":"2024101706482023000_2.3.00014-2016.21","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199805)25:5<304::AID-PPUL3>3.0.CO;2-I"},{"key":"2024101706482023000_2.3.00014-2016.22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/1469-0691.12272","article-title":"Season is associated with Pseudomonas aeruginosa acquisition in young children with cystic fibrosis","volume":"19","author":"Psoter","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"2024101706482023000_2.3.00014-2016.23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027784"},{"key":"2024101706482023000_2.3.00014-2016.24","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu077"},{"key":"2024101706482023000_2.3.00014-2016.25","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0132"},{"key":"2024101706482023000_2.3.00014-2016.26","first-page":"A5481","article-title":"Molecular epidemiology of Staphylococcus aureus infections in a paediatric treatment centre","volume":"185","author":"Hart","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101706482023000_2.3.00014-2016.27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120577109"},{"key":"2024101706482023000_2.3.00014-2016.28","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.jpedsurg.2006.05.014","article-title":"Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study","volume":"41","author":"Munck","year":"2006","journal-title":"J Pediatr Surg"},{"key":"2024101706482023000_2.3.00014-2016.29","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201309-303OC"},{"key":"2024101706482023000_2.3.00014-2016.30","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.00053701"},{"key":"2024101706482023000_2.3.00014-2016.31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301725"},{"key":"2024101706482023000_2.3.00014-2016.32","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199605)21:5<267::AID-PPUL1>3.0.CO;2-K"},{"key":"2024101706482023000_2.3.00014-2016.33","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.2.331"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00014-2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T04:53:22Z","timestamp":1740372802000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00014-2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,9,26]]},"published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1183\/23120541.00014-2016"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00014-2016","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}