{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:51:16Z","timestamp":1761562276244,"version":"3.37.3"},"reference-count":36,"publisher":"European Respiratory Society (ERS)","issue":"3","funder":[{"name":"National Institute of Environmental Health Sciences, United States","award":["D43ES018744"],"award-info":[{"award-number":["D43ES018744"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2017,7,3]]},"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>The accurate diagnosis of asbestos-related diseases is important because of past and current asbestos exposures. This study evaluated the reliability of clinical diagnoses of asbestos-related diseases in former mineworkers using autopsies as the reference standard.<\/jats:p><jats:p>Sensitivity, specificity, positive predictive value and negative predictive value were calculated.<\/jats:p><jats:p>The 149 cases identified had clinical examinations 0.3\u20137.4\u2005years before death. More asbestos-related diseases were diagnosed at autopsy rather than clinically: 77<jats:italic>versus<\/jats:italic>52 for asbestosis, 27<jats:italic>versus<\/jats:italic>14 for mesothelioma and 22<jats:italic>versus<\/jats:italic>3 for lung cancer. Sensitivity and specificity values for clinical diagnoses were 50.6% and 81.9% for asbestosis, 40.7% and 97.5% for mesothelioma, and 13.6% and 100.0% for lung cancer. False-negative diagnoses of asbestosis were more likely using radiographs of acceptable (<jats:italic>versus<\/jats:italic>good) quality and in cases with pulmonary tuberculosis at autopsy.<\/jats:p><jats:p>The low sensitivity values are indicative of the high proportion of false-negative diagnoses. It is unlikely that these were the result of disease manifestation between the last clinical assessment and autopsy. Where clinical features suggest asbestos-related diseases but the chest radiograph is negative, more sophisticated imaging techniques or immunohistochemistry for asbestos-related cancers should be used. Autopsies are useful for the detection of previously undiagnosed and misdiagnosed asbestos-related diseases, and for monitoring clinical practice and delivery of compensation.<\/jats:p>","DOI":"10.1183\/23120541.00022-2017","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T00:10:26Z","timestamp":1503706226000},"page":"00022-2017","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Asbestos-related diseases in mineworkers: a clinicopathological study"],"prefix":"10.1183","volume":"3","author":[{"given":"Ntombizodwa","family":"Ndlovu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naseema","family":"Vorajee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"teWaterNaude","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2017,8,25]]},"reference":[{"key":"2024101706544574000_3.3.00022-2017.1","unstructured":"Republic of South Africa . 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