{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:25:30Z","timestamp":1791066330191,"version":"4.1.0"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2015,8,28]]},"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Wood processing workers are exposed to wood-associated microbiological contaminants, including fungi. Our aim was to study the potential association between sputum fungus and adverse respiratory effects in such workers.<\/jats:p><jats:p>In a group of sawmill workers, we administered a respiratory questionnaire, performed lung function testing and quantified the proportions of leukocytes in spontaneously expectorated sputum samples. We identified fungal species by DNA sequencing.<\/jats:p><jats:p>Of 54 sawmill workers, 19 yielded fungal positive sputum samples (mean age 42.5\u00b110.4\u2005years) and 35 were negative for fungus (mean age 36.9\u00b15.2\u2005years). The fungus was identified as<jats:italic>Candida<\/jats:italic>sp. in all samples. Those with fungal-positive sputum, compared to others, reported more cough (26%<jats:italic>versus<\/jats:italic>63%) and haemoptysis (6%<jats:italic>versus<\/jats:italic>37%) (both p&lt;0.05), manifested reduced forced midexpiratory flow rates (FEF<jats:sub>25\u201375%<\/jats:sub>) (82.3\u00b14.5<jats:italic>versus<\/jats:italic>69.2\u00b19.9% predicted, p&lt;0.001), and had higher sputum eosinophil counts (median 9.25<jats:italic>versus<\/jats:italic>3.25%, p&lt;0.01). Reduction of FEF<jats:sub>25\u201375%<\/jats:sub>was associated both with fungus detection in sputum (\u221212.7%, 95% CI\u22128.5\u2013\u200a\u221216.9%) and sputum eosinophils (\u22122.1% per 1% increase in eosinophils, 95% CI \u22121.5\u2013\u200a\u22122.8%) (both p&lt;0.001).<\/jats:p><jats:p>In sawmill workers,<jats:italic>Candida<\/jats:italic>sp. detectable in sputum was associated with respiratory symptoms, sputum eosinophilia and reduced FEF<jats:sub>25\u201375%<\/jats:sub>.<\/jats:p>","DOI":"10.1183\/23120541.00023-2015","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T01:53:06Z","timestamp":1444182786000},"page":"00023-2015","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Fungal contamination of the respiratory tract and associated respiratory impairment among sawmill workers in India"],"prefix":"10.1183","volume":"1","author":[{"given":"Asit","family":"Adhikari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhashis","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arghya","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhabrata","family":"Moitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2015,10,6]]},"reference":[{"key":"2024101706102974000_1.2.00023-2015.1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1398-9995.1984.tb01978.x","article-title":"Nasal hypersensitivity in wood furniture workers. 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