{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:26:30Z","timestamp":1792643190419,"version":"4.5.0"},"reference-count":33,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201700001C"],"award-info":[{"award-number":["HHSN268201700001C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL105643"],"award-info":[{"award-number":["R01HL105643"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL126771"],"award-info":[{"award-number":["R01HL126771"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2022,3,10]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The diagnosis of pulmonary hypertension (PH) remains challenging. Pre- and post-capillary PH have different signatures on noninvasive\n                      <jats:sup>129<\/jats:sup>\n                      Xe gas-exchange magnetic resonance imaging (MRI) and dynamic MR spectroscopy (MRS). We tested the accuracy of\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI\/MRS to diagnose PH status compared to right heart catheterisation (RHC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI\/MRS from 93 subjects was used to develop a diagnostic algorithm, which was tested in 32 patients undergoing RHC on the same day (n=20) or within 5\u2005months (42\u00b140\u2005days) (n=12). Three expert readers, blinded to RHC, used\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI\/MRS to classify subjects as pre-capillary PH, post-capillary PH, no PH and no interstitial lung disease (ILD), or ILD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For pre-capillary PH,\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI\/MRS diagnostic accuracy was 75% (95% CI 66\u201384) with a sensitivity of 67% (95% CI 54\u201379) and a specificity of 86% (95% CI 75\u201396); for post-capillary PH accuracy was 69% (95% CI 59\u201378) with sensitivity of 54% (95% CI 34\u201374) and specificity of 74% (95% CI 63\u201384). The model performed well in straightforward cases of pre-capillary PH but was less accurate in its diagnosis in the presence of mixed disease, particularly in the presence of ILD or combined post- and pre-capillary PH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study demonstrates the potential to develop\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI\/MRS into a modality with good accuracy in detecting pre- and post-capillary PH. Furthermore, the combination of\n                      <jats:sup>129<\/jats:sup>\n                      Xe dynamic MRS and gas-exchange MRI uniquely provide concurrent, noninvasive assessment of both haemodynamics and gas-exchange impairment that may aid in the detection of PH.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/23120541.00035-2022","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T12:45:21Z","timestamp":1650545121000},"page":"00035-2022","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Noninvasive diagnosis of pulmonary hypertension with hyperpolarised\n                    <sup>129<\/sup>\n                    Xe magnetic resonance imaging and spectroscopy"],"prefix":"10.1183","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-3450","authenticated-orcid":false,"given":"Elianna 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