{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:51:57Z","timestamp":1779317517471,"version":"3.51.4"},"reference-count":22,"publisher":"European Respiratory Society (ERS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2019,9,23]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Acute noninvasive ventilation (NIV) is a well-established therapy for acute respiratory failure but the dose\u2013response characteristics of this therapy have not been defined. The aim of this study was to define this dose\u2013response relationship.<\/jats:p><jats:p>This study was a retrospective review of patients receiving NIV for acute respiratory failure in a tertiary hospital respiratory high-dependency unit between July 2012 and June 2017. Mask-on time (rather than the period that NIV was in use) as the \u201cdose\u201d was compared with hospital survival as the \u201cresponse\u201d.<\/jats:p><jats:p>654 patients were included, 594 (91%) with hypercapnic respiratory failure (HCRF). NIV was used for a median (interquartile range (IQR)) duration of 2.74 (1.51\u20134.73)\u2005days and median (IQR) mask-on time was 34 (18\u201360)\u2005h (56.1% (41.2\u201369.5%) of treatment time). There was evidence of a dose\u2013response relationship in the HCRF group up to a ceiling of 24\u2005h mask-on time, but not in the hypoxaemic respiratory failure (HRF) group. There was a difference in survival with as little as 2\u2005h mask-on time (92% compared with 73%; p&lt;0.001). Patients requiring NIV for 80\u2013100% of therapy time had lower survival.<\/jats:p><jats:p>We conclude that there is evidence of a dose\u2013response relationship between cumulative NIV usage (mask-on time) and survival from as little as 2\u2005h to a ceiling of \u223c24\u2005h in HCRF, but not in HRF.<\/jats:p>","DOI":"10.1183\/23120541.00041-2019","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T13:45:13Z","timestamp":1578923113000},"page":"00041-2019","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Dose\u2013response characteristics of noninvasive ventilation in acute respiratory failure"],"prefix":"10.1183","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-6852","authenticated-orcid":false,"given":"Craig","family":"Hukins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"2024101707434402000_6.1.00041-2019.1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/CCM.0000000000000819","article-title":"Noninvasive ventilation and survival in acute care settings: a comprehensive systematic review and metaanalysis of randomized controlled trials","volume":"43","author":"Cabrini","year":"2015","journal-title":"Crit Care Med"},{"key":"2024101707434402000_6.1.00041-2019.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60496-7"},{"key":"2024101707434402000_6.1.00041-2019.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02323-0"},{"key":"2024101707434402000_6.1.00041-2019.4","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.6.7767523"},{"key":"2024101707434402000_6.1.00041-2019.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12402"},{"key":"2024101707434402000_6.1.00041-2019.6","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afr003"},{"key":"2024101707434402000_6.1.00041-2019.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102153440703"},{"key":"2024101707434402000_6.1.00041-2019.8","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.94531"},{"key":"2024101707434402000_6.1.00041-2019.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00045-3"},{"key":"2024101707434402000_6.1.00041-2019.10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200103)24:3<403::AID-MUS1013>3.0.CO;2-3"},{"key":"2024101707434402000_6.1.00041-2019.11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117808"},{"key":"2024101707434402000_6.1.00041-2019.12","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.039388"},{"key":"2024101707434402000_6.1.00041-2019.13","doi-asserted-by":"crossref","unstructured":"Sorbo LD , Martin E , Ranieri VM Hypoxic respiratory failure. In: Mason RJ , Broaddus VC , Martin TR , et al. , eds. Murray and Nadel's Textbook of Respiratory Medicine . 5 edn. 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