{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:08:46Z","timestamp":1792681726466,"version":"4.5.0"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2020,6,3]]},"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Obstructive sleep apnoea\u2013hypopnoea syndrome (OSAHS) carries substantial negative health consequences. This study examines factors affecting mortality and morbidity according to continuous positive airway pressure (CPAP) use and predictors affecting CPAP adherence in a longitudinal cohort of OSAHS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This prospective, cohort study comprised 4502 patients who were diagnosed with OSAHS at a tertiary sleep disorders centre between 1982 and 2003. Of these, 1174 patients completed follow-up in 2012. Data collected included anthropometric, sleep and demographic characteristics, including comorbidities, ongoing medications and CPAP adherence. Patients were followed up for an average of 14.8\u00b13.7\u2005years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Imputation analysis showed that long-term CPAP users (&gt;5\u2005years) were 5.63 times more likely to be alive at study end than non-CPAP users (95% CI: 4.83\u20136.58, p&lt;0.001) and 1.74-times more likely than short-term CPAP users (\u22645\u2005years) (95% CI: 1.49\u20132.02, p&lt;0.001). Females had a significantly higher mortality rate during the follow-up period (26.8%<jats:italic>versus<\/jats:italic>19.6%, p&lt;0.001). Respiratory mortality was more common in patients with OSAHS, in particular those who did not use CPAP, compared to the general population (17.2%<jats:italic>versus<\/jats:italic>12.2%, p=0.002 respectively), whereas deaths from cancer were less common compared to the general population (16.2%<jats:italic>versus<\/jats:italic>25.6%, p&lt;0.001). Compared to CPAP users, non-CPAP-users had a significantly increased incidence of type II diabetes mellitus (DMII) (27.9%<jats:italic>versus<\/jats:italic>18.7%, p=0.003), ischaemic heart disease (IHD) (25.5%<jats:italic>versus<\/jats:italic>12.7%, p&lt;0.001) and myocardial infarction (MI) (14.7%<jats:italic>versus<\/jats:italic>4.2%, p&lt;0.001) at long-term follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long-term CPAP use in men and women with OSAHS reduces mortality and decreases the incidence of DMII and cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00057-2020","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T12:55:59Z","timestamp":1600088159000},"page":"00057-2020","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":98,"title":["Mortality and morbidity in obstructive sleep apnoea\u2013hypopnoea syndrome: results from a 30-year prospective cohort study"],"prefix":"10.1183","volume":"6","author":[{"given":"Sophie","family":"Dodds","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Roguski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Vennelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6092-1341","authenticated-orcid":false,"given":"Serafeim-Chrysovalantis","family":"Kotoulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8983-9985","authenticated-orcid":false,"given":"Renata L.","family":"Riha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"2024101707563288000_6.3.00057-2020.1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.rmedc.2009.03.001","article-title":"The obstructive sleep apnoea\/hypopnoea syndrome \u2013 An overview","volume":"2","author":"Pataka","year":"2009","journal-title":"Respir Med CME"},{"key":"2024101707563288000_6.3.00057-2020.2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069432"},{"key":"2024101707563288000_6.3.00057-2020.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.901801"},{"key":"2024101707563288000_6.3.00057-2020.4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/NSS.S75166","article-title":"All-cause mortality from obstructive sleep apnea in male and female patients with and without continuous positive airway pressure treatment: a registry study with 10 years of follow-up","volume":"7","author":"Jennum","year":"2015","journal-title":"Nat Sci Sleep"},{"key":"2024101707563288000_6.3.00057-2020.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"2024101707563288000_6.3.00057-2020.6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12931-018-0761-8","article-title":"Effect of continuous positive airway pressure on long-term cardiovascular outcomes in patients with coronary artery disease and obstructive sleep apnea: a systematic review and meta-analysis","volume":"19","author":"Wang","year":"2018","journal-title":"Respir Res"},{"key":"2024101707563288000_6.3.00057-2020.7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/eci.12011","article-title":"Comorbidities and survival in obstructive sleep apnoea beyond the age of 50","volume":"43","author":"Marrone","year":"2013","journal-title":"Eur J Clin Invest"},{"key":"2024101707563288000_6.3.00057-2020.8","unstructured":"World Medical Association. 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