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In addition, we compared IOS findings in chronic obstructive pulmonary disease (COPD) patients with and without EDAC.<\/jats:p><jats:p>EDAC was identified at bronchoscopy as 75\u2013100% expiratory closure at the carina or bilateral main bronchi. Four patient groups were compared: controls with no EDAC and normal lung function; lone EDAC with normal lung function; COPD-only patients; and COPD patients with EDAC.<\/jats:p><jats:p>38 patients were studied. Mean IOS data z-scores for EDAC compared to controls showed significantly higher reactance (<jats:italic>X<\/jats:italic>) values including<jats:italic>X<\/jats:italic>at 5\u2005Hz, resonance frequency and area under the reactance curve (A<jats:sub>X<\/jats:sub>). EDAC showed significantly greater expiratory\/inspiratory differences in all IOS data compared to controls. Stepwise logistic regression showed that resonant frequency best discriminated between EDAC and normal control, whereas classification and regression tree analysis found A<jats:sub>X<\/jats:sub>\u22653.523 to be highly predictive for EDAC in cases with normal lung function (14 out of 15 cases, and none out of eight controls).<\/jats:p><jats:p>These data show a new utility of IOS: detecting EDAC in patients with normal lung function.<\/jats:p>","DOI":"10.1183\/23120541.00080-2018","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T08:25:35Z","timestamp":1542011135000},"page":"00080-2018","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Expiratory reactance abnormalities in patients with expiratory dynamic airway collapse: a new application of impulse oscillometry"],"prefix":"10.1183","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2311-4919","authenticated-orcid":false,"given":"David I.","family":"Fielding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Travers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunter","family":"Hartel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"2024101707122100000_4.4.00080-2018.1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ccm.2013.05.003","article-title":"Tracheobronchomalacia and excessive dynamic airway collapse","volume":"34","author":"Murgu","year":"2013","journal-title":"Clin Chest Med"},{"key":"2024101707122100000_4.4.00080-2018.2","first-page":"600","article-title":"[Dynamic airway collapse. 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