{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:08:10Z","timestamp":1740460090730,"version":"3.37.3"},"reference-count":11,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2020,7,3]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Proper staging of the mediastinum is an essential component of lung cancer evaluation. Positron emission tomography\u2013computed tomography (PETCT) and endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) are an integral part of this process. False-positive PETCT results can occur following surgical procedures but has not been demonstrated following EBUS-TBNA. We aimed to determine whether false-positive PETCT rates increase when EBUS-TBNA is performed prior to PETCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design and methods<\/jats:title><jats:p>A retrospective review was carried out of clinical cases that underwent both PETCT and EBUS-TBNA within 30 days for the suspected malignancy. The impact of test sequence on the PETCT false-positive rate (FPR) was determined using Generalised Estimating Equation logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 675 lymph node stations were sampled and imaged on PETCT. Overall, 332 (49.2%) nodes were sampled by EBUS-TBNA before PETCT, and 343 (50.8%) afterwards, with the interval between EBUS and subsequent PETCT being a mean\u00b1<jats:sc>sd<\/jats:sc>of 11.6\u00b16.8 days (range 1\u201329). The FPR on qualitative PETCT for the EBUS first group was 41 (23.2%) out of 164, and for PETCT first it was 57 (29.0%) out of 193 for a difference of 5.8% (95% CI \u22123.4\u201314.7, p=0.22). In the regression model, EBUS as the first test was associated with a lower FPR when using the clinical PETCT interpretation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The performance of EBUS-TBNA sampling did not influence the FPR of PETCT when bronchoscopy took place in the 30 days prior to testing. Test sequence should be selected based on other clinical considerations.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00103-2020","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T12:50:14Z","timestamp":1601902214000},"page":"00103-2020","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Does prior mediastinal lymph node aspiration contribute to false-positive positron emission tomography\u2013computed tomography?"],"prefix":"10.1183","volume":"6","author":[{"given":"J. Michael","family":"Ramsahai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Molnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winston","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"MacEachern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher 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EBUS in staging non-small cell lung cancer and diagnosing benign diseases","volume":"20","author":"Dincer","year":"2013","journal-title":"J Bronchology Interv Pulmonol"},{"key":"2024101708022524000_6.4.00103-2020.5","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000129124.52554.92"},{"key":"2024101708022524000_6.4.00103-2020.6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S1516-89132007000600004","article-title":"Common causes of false positive F18 FDG PET\/CT scans in oncology","volume":"50","author":"Carter","year":"2007","journal-title":"Braz Arch Biol Technol"},{"key":"2024101708022524000_6.4.00103-2020.7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/MNM.0000000000000616","article-title":"18F-FDG-PET\/CT study after lung biopsy in suspected lung cancer patients: time is of the essence","volume":"38","author":"Yeung","year":"2017","journal-title":"Nucl Med 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