{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:09:04Z","timestamp":1740460144176,"version":"3.37.3"},"reference-count":38,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2021,5,13]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Advanced hepatic fibrosis and cirrhosis are absolute contraindications to lung transplantation. [ 1] However, whether fatty liver disease with mild\u2013moderate fibrosis contributes to increased adverse outcomes post-lung transplantation remains unknown.<\/jats:p><jats:p>\u2003We present a retrospective analysis of patients transplanted at Brigham and Women's Hospital between 2015 and 2017 to identify whether patients with mild\u2013moderate non-alcoholic fatty liver disease (NAFLD) experience increased short-term complications compared to patients with normal liver architecture. Patients with advanced (F3\u2013F4) fibrosis and\/or cirrhosis were considered non-suitable transplant candidates,<jats:italic>a priori<\/jats:italic>. This study was powered for a difference in index hospital-free days within the first 30\u2005days of 25% (\u03b1=0.05, \u03b2=0.8). Secondary outcomes included index intensive care unit (ICU)-free days within the first 10\u2005days post-transplant, perioperative blood product transfusion, incidence of index hospitalisation arrhythmias and delirium, need for insulin on discharge post-transplant, tacrolimus dose required to maintain a trough of 8\u201312\u2005ng\u00b7mL<jats:sup>\u22121<\/jats:sup>at index hospital discharge, and 1-year post-transplant incidence of insulin-dependent diabetes, acute kidney injury, acute cellular rejection, unplanned hospital readmissions and infection.<\/jats:p><jats:p>\u2003150 patients underwent lung transplantation between 2015 and 2017 and were included in the analysis; of these patients 40 (27%) had evidence of NAFLD. Median index hospital-free days for patients with NAFLD were non-inferior to those without (16\u2005days, IQR 10.5\u201319.5<jats:italic>versus<\/jats:italic>12\u2005days, IQR 0\u201318.0, p=0.03). Regarding secondary outcomes, both index hospitalisation and 1-year outcomes were non-inferior between patients with NAFLD and those with normal liver architecture.<\/jats:p><jats:p>\u2003This study demonstrates that mild\u2013moderate severity NAFLD may not be a contraindication to lung transplantation.<\/jats:p>","DOI":"10.1183\/23120541.00103-2021","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T10:35:12Z","timestamp":1621593312000},"page":"00103-2021","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["1-year outcomes for lung transplantation recipients with non-alcoholic fatty liver disease"],"prefix":"10.1183","volume":"7","author":[{"given":"Anil 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