{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:31:05Z","timestamp":1780774265553,"version":"3.54.1"},"reference-count":41,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"DOI":"10.13039\/501100004913","name":"Universit\u00e0 degli Studi di Palermo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2018,3,28]]},"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>We tested the hypothesis that dynamic hyperinflation develops in severe asthmatic subjects during exercise. Changes in inspiratory capacity (IC) were measured during the 6-min walk test (6MWT) in severe asthmatic subjects compared with chronic obstructive pulmonary disease (COPD) subjects with a similar degree of bronchial obstruction. We assessed whether changes in IC were associated with changes in dyspnoea perception.<\/jats:p><jats:p>27 severe asthmatic subjects (10 males and 17 females) and 43 COPD subjects (35 males and eight females) were recruited. The two groups performed similarly in the 6MWT (p=0.90). At the end of the test, the Borg score increased significantly in both groups (mean difference: for asthmatic subjects 1.7\u00b11.6; p&lt;0.0001; for COPD subjects 3.1\u00b11.9; p&lt;0.0001). IC measured at the beginning of 6MWT was not different between groups (2.25\u00b10.47\u2005L in asthmatic subjects<jats:italic>versus<\/jats:italic>2.38\u00b10.60\u2005L in COPD subjects; p=0.32) and decreased in both groups (mean difference: for asthmatic subjects 0.160\u2005L; p=0.02; for COPD subjects 0.164\u2005L; p&lt;0.0001). However, changes in IC were significantly associated with changes in the Borg score in the COPD group (r<jats:sup>2<\/jats:sup>=0.17; p=0.006), but not in the asthma group (r<jats:sup>2<\/jats:sup>=0.06; p=0.20).<\/jats:p><jats:p>In severe asthmatic subjects, IC significantly drops during the 6MWT to the same extent as COPD subjects with a similar degree of lung impairment, indicating the development of dynamic hyperinflation. Contrary to COPD, in asthmatic subjects the occurrence of dynamic hyperinflation was not associated with changes in dyspnoea perception.<\/jats:p>","DOI":"10.1183\/23120541.00143-2017","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T08:05:11Z","timestamp":1526630711000},"page":"00143-2017","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects"],"prefix":"10.1183","volume":"4","author":[{"given":"Alida","family":"Benfante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano","family":"Di 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