{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:50:10Z","timestamp":1778539810941,"version":"3.51.4"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"6","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Chamber of Deputies of Mexico"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2024,5,11]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>COPD due to biomass exposure (COPD-B) is highly prevalent in low- and middle-income countries, and there are no clinical trials designed to evaluate the effectiveness of the treatments currently recommended for patients with COPD due to cigarette smoking (COPD-C). The purpose of the study was to compare the efficacy of fluticasone furoate\/vilanterol (FF\/V) 100\/25\u2005\u03bcg and umeclidinium\/vilanterol (UMEC\/VI) 62.5\/25\u2005\u03bcg on the rate of exacerbations, the time to first exacerbation, on dyspnoea, health-related quality of life (HRQL), forced expiratory volume in 1\u2005s (FEV<jats:sub>1<\/jats:sub>) and inspiratory capacity (IC) during a period of 6\u2005months in patients with COPD-B and COPD-C, at a third level referral centre in Mexico City.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pilot, single-centre, open-label, parallel-group study included 132 patients with a history of at least two exacerbations. They were randomised to receive one of four treatment groups: 33 COPD-B patients received FF\/VI 100\/25\u2005\u03bcg, 31 COPD-B patients received UMEC\/VI 62.5\/25\u2005\u03bcg, 34 COPD-C patients received FF\/V and 34 COPD-C patients received UMEC\/VI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences in exacerbation rates between patients receiving FF\/VI or UMEC\/VI in either the COPD-B (0.07 (95% CI 0.03\u20130.13), 0.06 (95% CI 0.03\u20130.12)) or COPD-C group (0.06 (95% CI 0.04\u20130.11), 0.08 (95% CI 0.05\u20130.13)), nor in the time of first exacerbation, nor FEV<jats:sub>1<\/jats:sub>and IC. All groups showed improvement in dyspnoea and HRQL, independently of medication used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with COPD-B and COPD-C with a history of exacerbation, FF\/VI was equally effective as UMEC\/VI in preventing exacerbations and improving dyspnoea and HRQL.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00154-2024","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T15:30:15Z","timestamp":1720107015000},"page":"00154-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of ICS\/LABA and LAMA\/LABA in COPD due to biomass"],"prefix":"10.1183","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2673-5753","authenticated-orcid":false,"given":"Alejandra","family":"Ram\u00edrez-Venegas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8107-1788","authenticated-orcid":false,"given":"Francisco","family":"Montiel-Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-7368","authenticated-orcid":false,"given":"Robinson E.","family":"Robles-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7266-8371","authenticated-orcid":false,"given":"Bartolome R.","family":"Celli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-0700","authenticated-orcid":false,"given":"Ra\u00fal H.","family":"Sansores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maricruz","family":"Cassou-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8427-2078","authenticated-orcid":false,"given":"Jos\u00e9 L. P\u00e9rez","family":"Lara-Albisua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Gonz\u00e1lez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda E.","family":"Mayar-Maya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloisa P.","family":"Hern\u00e1ndez-Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8710-160X","authenticated-orcid":false,"given":"Rafael J.","family":"Hern\u00e1ndez-Zenteno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6877-8124","authenticated-orcid":false,"given":"Ramc\u00e9s","family":"Falf\u00e1n-Valencia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-2588","authenticated-orcid":false,"given":"Ireri","family":"Thiri\u00f3n-Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"P\u00e9rez-Bautista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1132-5308","authenticated-orcid":false,"given":"Rogelio","family":"P\u00e9rez-Padilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"2025011303500723000_10.6.00154-2024.1","doi-asserted-by":"crossref","first-page":"106726","DOI":"10.1016\/j.rmed.2021.106726","article-title":"Distribution of chronic cough phenotypes in the general population: a cross-sectional analysis of the LEAD cohort in Austria","volume":"192","author":"Abozid","year":"2022","journal-title":"Respir Med"},{"key":"2025011303500723000_10.6.00154-2024.2","doi-asserted-by":"crossref","first-page":"700836","DOI":"10.3389\/fmed.2021.700836","article-title":"The \u201cSlow Horse Racing Effect\u201d on lung function in adult life in chronic obstructive pulmonary disease associated to biomass exposure","volume":"8","author":"Ram\u00edrez-Venegas","year":"2021","journal-title":"Front Med"},{"key":"2025011303500723000_10.6.00154-2024.3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0140-6736(22)01273-9","article-title":"Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission","volume":"400","author":"Stolz","year":"2022","journal-title":"The Lancet"},{"key":"2025011303500723000_10.6.00154-2024.4","doi-asserted-by":"publisher","DOI":"10.1590\/S0042-96862000000900004"},{"key":"2025011303500723000_10.6.00154-2024.5","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.24875\/RIC.18002652","article-title":"Small airway disease in COPD associated to biomass exposure","volume":"71","author":"Ram\u00edrez-Venegas","year":"2019","journal-title":"RIC"},{"key":"2025011303500723000_10.6.00154-2024.6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00206112"},{"key":"2025011303500723000_10.6.00154-2024.7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12931-018-0718-y","article-title":"Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both","volume":"19","author":"Olloquequi","year":"2018","journal-title":"Respir Res"},{"key":"2025011303500723000_10.6.00154-2024.8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.clim.2015.07.009","article-title":"Chronic obstructive pulmonary disease induced by exposure to biomass smoke is associated with a Th2 cytokine production profile","volume":"161","author":"Solleiro-Villavicencio","year":"2015","journal-title":"Clin Immunol"},{"key":"2025011303500723000_10.6.00154-2024.9","doi-asserted-by":"crossref","first-page":"191209","DOI":"10.5696\/2156-9614-9.24.191209","article-title":"Eosinophilic airway inflammation in patients with stable biomass smoke- versus tobacco smoke-associated chronic obstructive pulmonary disease","volume":"9","author":"Fernandes","year":"2019","journal-title":"J Health Pollut"},{"key":"2025011303500723000_10.6.00154-2024.10","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jaci.2018.06.052","article-title":"Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries","volume":"143","author":"Morgan","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"2025011303500723000_10.6.00154-2024.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2012.03.007"},{"key":"2025011303500723000_10.6.00154-2024.12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.arbres.2017.01.002","article-title":"Global Initiative for Chronic Obstructive Lung Disease (GOLD)-2017: la visi\u00f3n desde alat","volume":"53","author":"Montes de Oca","year":"2017","journal-title":"Arch Bronconeumol"},{"key":"2025011303500723000_10.6.00154-2024.13","doi-asserted-by":"crossref","first-page":"e20200033","DOI":"10.36416\/1806-3756\/e20200033","article-title":"Clinical, laboratory, and functional characteristics of asthma-COPD overlap in patients with a primary diagnosis of COPD","volume":"47","author":"Adriano Queiroz","year":"2021","journal-title":"J Bras Pneumol"},{"key":"2025011303500723000_10.6.00154-2024.14","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLD) . Global Strategy for Prevention, Diagnosis and Management of COPD. 2023 report. https:\/\/goldcopd.org\/2023-gold-report-2\/"},{"key":"2025011303500723000_10.6.00154-2024.15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.arbres.2021.03.005","article-title":"Actualizaci\u00f3n 2021 de la Gu\u00eda Espa\u00f1ola de la EPOC (GesEPOC). Tratamiento farmacol\u00f3gico de la EPOC estable","volume":"58","author":"Miravitlles","year":"2022","journal-title":"Archivos de Bronconeumolog\u00eda"},{"key":"2025011303500723000_10.6.00154-2024.16","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4486"},{"key":"2025011303500723000_10.6.00154-2024.17","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.3.8810608"},{"key":"2025011303500723000_10.6.00154-2024.18","doi-asserted-by":"publisher","DOI":"10.4104\/pcrj.2009.00053"},{"key":"2025011303500723000_10.6.00154-2024.19","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2147\/COPD.S82408","article-title":"Modified Medical Research Council scale vs Baseline Dyspnea Index to evaluate dyspnea in chronic obstructive pulmonary disease","volume":"10","author":"Perez","year":"2015","journal-title":"COPD"},{"key":"2025011303500723000_10.6.00154-2024.20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.6.1321"},{"key":"2025011303500723000_10.6.00154-2024.21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2025011303500723000_10.6.00154-2024.22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1590\/S0036-36342001000200006","article-title":"Reproducibilidad de espirometr\u00edas en trabajadores mexicanos y valores de referencia internacionales","volume":"43","author":"P\u00e9rez-Padilla","year":"2001","journal-title":"Salud p\u00fablica M\u00e9x"},{"key":"2025011303500723000_10.6.00154-2024.23","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9712108"},{"key":"2025011303500723000_10.6.00154-2024.24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"2025011303500723000_10.6.00154-2024.25","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00016-2016"},{"key":"2025011303500723000_10.6.00154-2024.26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"2025011303500723000_10.6.00154-2024.27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201310-1863PP"},{"key":"2025011303500723000_10.6.00154-2024.28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S2213-2600(14)70001-3","article-title":"Minimum clinically important difference for the COPD Assessment Test: a prospective analysis","volume":"2","author":"Kon","year":"2014","journal-title":"Lancet Respir Med"},{"key":"2025011303500723000_10.6.00154-2024.29","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00068-2017"},{"key":"2025011303500723000_10.6.00154-2024.30","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJMoa1608033","article-title":"Effectiveness of fluticasone furoate\u2013vilanterol for COPD in clinical practice","volume":"375","author":"Vestbo","year":"2016","journal-title":"N Engl J Med"},{"key":"2025011303500723000_10.6.00154-2024.31","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1007\/s12325-021-01855-y","article-title":"Efficacy and safety of umeclidinium\/vilanterol in current and former smokers with COPD: a prespecified analysis of The EMAX Trial","volume":"38","author":"Bjermer","year":"2021","journal-title":"Adv Ther"},{"key":"2025011303500723000_10.6.00154-2024.32","doi-asserted-by":"crossref","first-page":"105938","DOI":"10.1016\/j.rmed.2020.105938","article-title":"Goals of COPD treatment: focus on symptoms and exacerbations","volume":"166","author":"Vogelmeier","year":"2020","journal-title":"Respir Med"},{"key":"2025011303500723000_10.6.00154-2024.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.02.646"},{"key":"2025011303500723000_10.6.00154-2024.34","doi-asserted-by":"crossref","unstructured":"Nannini LJ , Poole P , Milan SJ , et al. Combined corticosteroid and long-acting beta2-agonist in one inhaler versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2013; 11: CD003794. doi:10.1002\/14651858.CD003794.pub4","DOI":"10.1002\/14651858.CD003794.pub4"},{"key":"2025011303500723000_10.6.00154-2024.35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12931-020-1310-9","article-title":"Phenotypic comparison between smoking and non-smoking chronic obstructive pulmonary disease","volume":"21","author":"Salvi","year":"2020","journal-title":"Respir Res"},{"key":"2025011303500723000_10.6.00154-2024.36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/COPD.S52416","article-title":"Comparison of clinical features between non-smokers with COPD and smokers with COPD: a retrospective observational study","volume":"9","author":"Zhang","year":"2014","journal-title":"COPD"},{"key":"2025011303500723000_10.6.00154-2024.37","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.2147\/COPD.S201314","article-title":"Bronchodilators for hyperinflation in COPD associated with biomass smoke: clinical trial","volume":"14","author":"Ram\u00edrez-Venegas","year":"2019","journal-title":"COPD"},{"key":"2025011303500723000_10.6.00154-2024.38","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.arbres.2013.12.013","article-title":"Distribuci\u00f3n de fenotipos cl\u00ednicos en pacientes con enfermedad pulmonar obstructiva cr\u00f3nica por humo de biomasa y por tabaco","volume":"50","author":"Golpe","year":"2014","journal-title":"Archivos de Bronconeumolog\u00eda"},{"key":"2025011303500723000_10.6.00154-2024.39","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2147\/COPD.S30410","article-title":"Bronchial hyperresponsiveness in women with chronic obstructive pulmonary disease related to wood smoke","volume":"9","author":"Gonzalez-Garcia","year":"2012","journal-title":"COPD"},{"key":"2025011303500723000_10.6.00154-2024.40","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01499-2021"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00154-2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:38:23Z","timestamp":1740375503000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00154-2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,11,25]]},"published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1183\/23120541.00154-2024"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00154-2024","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,4]]}}}